OGA and C6

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		OGA	C6
Description		O-GlcNAcase	complement C6
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Membrane	Extracellular Region Membrane Attack Complex Extracellular Space Plasma Membrane Membrane Other Organism Cell Membrane Extracellular Exosome Transmembrane Transporter Complex
	Molecular Function	Hyalurononglucosaminidase Activity Hexosaminidase Activity Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Identical Protein Binding [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase Activity Catalytic Activity, Acting On A Protein	Protein Binding
	Biological Process	N-acetylglucosamine Metabolic Process Protein O-linked Glycosylation Glycoprotein Catabolic Process Protein Deglycosylation Glycoprotein Metabolic Process	In Utero Embryonic Development Immune System Process Immune Response Complement Activation Complement Activation, Classical Pathway Killing Of Cells Of Another Organism Innate Immune Response Positive Regulation Of Immune Response Complement Activation, GZMK Pathway
Pathways			Terminal pathway of complement Regulation of Complement cascade
Drugs		Streptozocin
Diseases			Late complement pathway defects, including the following seven diseases: C5 deficiency; C6 deficiency; C7 deficiency; C8 alpha-chain deficiency; C8 beta-chain deficiency; C8 gamma-chain deficiency; C9 deficiency
GWAS			Refractive error ( 32231278) Response to fenofibrate (adiponectin levels) ( 23149075)
Interacting Genes		10 interacting genes: A2M C6 CDC37 CSNK2B DHX9 GSK3B MAST1 OGT PSEN2 RNF32	4 interacting genes: C5 F2 OGA SART3
Entrez ID		10724	729
HPRD ID		04949	01956
Ensembl ID		ENSG00000198408	ENSG00000039537
Uniprot IDs		O60502	P13671
PDB IDs		2YDQ 5M7R 5M7S 5M7T 5M7U 5TKE 5UHK 5UHL 5UHO 5UHP 5UN8 5UN9 5VVO 5VVT 5VVU 5VVV 5VVX 6HKI 6PM9 7OU6 7YEH 8P0L 9BA8 9BA9	3T5O 4A5W 4E0S 6H03 6H04 7NYC 7NYD 7Q6C 8B0F 8B0G 8B0H
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Protein Kinase Regulator Activity Negative Regulation Of Catabolic Process Negative Regulation Of Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Viral Process Positive Regulation Of Translation Regulation Of Ubiquitin-dependent Protein Catabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Proteasomal Protein Catabolic Process Post-transcriptional Regulation Of Gene Expression Pyroptotic Inflammatory Response Rhythmic Process 3'-5' DNA/RNA Helicase Activity DNA-templated Viral Transcription Positive Regulation Of Nucleocytoplasmic Transport Regulatory Region RNA Binding Regulation Of Microtubule Anchoring At Centrosome Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Negative Regulation Of Complement Activation, Lectin Pathway Phosphorylation Protein Phosphorylation Regulation Of Protein Catabolic Process Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Negative Regulation Of Cell Migration Regulation Of Proteolysis Regulation Of Protein Metabolic Process Chromatin DNA Binding Triplex DNA Binding Superior Temporal Gyrus Development TOR Signaling Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Glycogen (starch) Synthase Activity Scaffold Protein Binding HSP90-CDC37 Chaperone Complex Protein Serine/threonine Kinase Activity Regulation Of Immune Response Protease Binding Interleukin-8 Binding Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Positive Regulation Of Viral Transcription Single-stranded 3'-5' DNA Helicase Activity	Receptor Ligand Activity Killing Of Cells Of Another Organism U4atac/U6atac SnRNP U6atac SnRNA Binding U6atac SnRNP [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase Activity Cell Killing U4/U6 SnRNP Hexosaminidase Activity Thrombospondin Receptor Activity ASAP Complex Catalytic Activity, Acting On A Protein Humoral Immune Response Other Organism Cell Membrane Negative Regulation Of Macrophage Chemotaxis Membrane Attack Complex Neutrophil-mediated Killing Of Gram-negative Bacterium Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Transcription Elongation-coupled Chromatin Remodeling U4 SnRNA Binding Hyalurononglucosaminidase Activity Complement Activation, Lectin Pathway Transmembrane Transporter Complex Signaling Receptor Binding Negative Regulation Of Macrophage Migration Complement Activation, GZMK Pathway Immune Effector Process Thrombin-activated Receptor Signaling Pathway Negative Regulation Of Astrocyte Differentiation Neutrophil-mediated Killing Of Bacterium Cytolysis By Host Of Symbiont Cells Negative Regulation Of Fibrinolysis U6 SnRNA Binding Complement Activation, Alternative Pathway N-acetylglucosamine Metabolic Process Regulation Of Fibrinolysis Negative Regulation Of Platelet Activation Spliceosomal Tri-snRNP Complex Assembly Fibrinolysis Ubiquitin-specific Protease Binding Protein Deglycosylation Negative Regulation Of Leukocyte Chemotaxis Neutrophil Mediated Immunity Positive Regulation Of Collagen Biosynthetic Process Inflammatory Response Negative Regulation Of Glial Cell Differentiation Hematopoietic Stem Cell Proliferation Positive Regulation Of Blood Coagulation Positive Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Macrophage Chemotaxis
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