OGA and MAST1

Number of citations of the paper that reports this interaction (PubMedID 21163940)
58

Data Source:
BioGRID (two hybrid)

		OGA	MAST1
Description		O-GlcNAcase	microtubule associated serine/threonine kinase 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Membrane	Cytoplasm Cytoskeleton Plasma Membrane Microtubule Cytoskeleton Membrane Axon Dendrite Cell Projection Neuron Projection Neuronal Cell Body
	Molecular Function	Hyalurononglucosaminidase Activity Hexosaminidase Activity Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Identical Protein Binding [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase Activity Catalytic Activity, Acting On A Protein	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Microtubule Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	N-acetylglucosamine Metabolic Process Protein O-linked Glycosylation Glycoprotein Catabolic Process Protein Deglycosylation Glycoprotein Metabolic Process	Protein Phosphorylation Cytoskeleton Organization Brain Development Developmental Process Intracellular Signal Transduction
Pathways
Drugs		Streptozocin	Fostamatinib
Diseases
GWAS			High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 32888494) Intelligence (MTAG) ( 29326435) Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 27863252 32888494) Red blood cell count ( 29403010) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		10 interacting genes: A2M C6 CDC37 CSNK2B DHX9 GSK3B MAST1 OGT PSEN2 RNF32	41 interacting genes: A2M ACE2 AP1M2 APOE APP BLMH CDK5 CYP2C8 CYP2C9 DNAJB1 ECSIT EGFR ELAVL3 EXOC6 EXOSC1 FBXL12 FBXW4 GCDH IFIT3 IFIT5 LONP1 LOXL4 NOS3 OGA PAXIP1 PRAM1 PRDX2 PSEN2 PTEN RAB3A RAB3D RAD23A RNF32 RNLS RPP30 RPS6KA1 SNTA1 SNTB2 STAMBPL1 TIAM1 VANGL2
Entrez ID		10724	22983
HPRD ID		04949	17469
Ensembl ID		ENSG00000198408	ENSG00000105613
Uniprot IDs		O60502	Q9Y2H9
PDB IDs		2YDQ 5M7R 5M7S 5M7T 5M7U 5TKE 5UHK 5UHL 5UHO 5UHP 5UN8 5UN9 5VVO 5VVT 5VVU 5VVV 5VVX 6HKI 6PM9 7OU6 7YEH 8P0L 9BA8 9BA9	2M9X 3PS4
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Protein Kinase Regulator Activity Negative Regulation Of Catabolic Process Negative Regulation Of Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Viral Process Positive Regulation Of Translation Regulation Of Ubiquitin-dependent Protein Catabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Proteasomal Protein Catabolic Process Post-transcriptional Regulation Of Gene Expression Pyroptotic Inflammatory Response Rhythmic Process 3'-5' DNA/RNA Helicase Activity DNA-templated Viral Transcription Positive Regulation Of Nucleocytoplasmic Transport Regulatory Region RNA Binding Regulation Of Microtubule Anchoring At Centrosome Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Negative Regulation Of Complement Activation, Lectin Pathway Phosphorylation Protein Phosphorylation Regulation Of Protein Catabolic Process Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Negative Regulation Of Cell Migration Regulation Of Proteolysis Regulation Of Protein Metabolic Process Chromatin DNA Binding Triplex DNA Binding Superior Temporal Gyrus Development TOR Signaling Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Glycogen (starch) Synthase Activity Scaffold Protein Binding HSP90-CDC37 Chaperone Complex Protein Serine/threonine Kinase Activity Regulation Of Immune Response Protease Binding Interleukin-8 Binding Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Positive Regulation Of Viral Transcription Single-stranded 3'-5' DNA Helicase Activity	Lipoprotein Particle Acetylcholine Receptor Activator Activity Negative Regulation Of Smooth Muscle Cell Proliferation Caffeine Oxidase Activity Intermediate-density Lipoprotein Particle Positive Regulation Of Amyloid Fibril Formation Chemical Synaptic Transmission Catabolic Process Cytosol Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Trans-synaptic Signaling Oxidative Demethylation Synaptic Signaling Cellular Response To Amyloid-beta Positive Regulation Of Regulated Secretory Pathway Regulation Of Regulated Secretory Pathway Omega-hydroxylase P450 Pathway Oxidoreductase Activity Arachidonate Epoxygenase Activity Regulation Of Neuronal Synaptic Plasticity Regulation Of Wound Healing Negative Regulation Of Long-term Synaptic Potentiation Regulation Of System Process Regulation Of Blood Circulation Demethylation Regulation Of Dendritic Spine Maintenance Response To Amyloid-beta Regulation Of Smooth Muscle Cell Proliferation Learning Or Memory Axonogenesis Epoxygenase P450 Pathway Low-density Lipoprotein Particle Removal Of Superoxide Radicals Negative Regulation Of Wound Healing Regulation Of Blood Coagulation Positive Regulation Of Membrane Protein Ectodomain Proteolysis Myosin V Binding Dystrophin-associated Glycoprotein Complex Regulation Of Hemostasis Heparan Sulfate Proteoglycan Binding Intracellular Signaling Cassette Regulation Of Amyloid Fibril Formation Regulation Of Response To Wounding Negative Regulation Of Platelet Activation Cognition Cellular Oxidant Detoxification Regulation Of Transport Ubiquitin-specific Protease Binding Very-low-density Lipoprotein Particle Regulation Of Amyloid-beta Clearance
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