EIF5A and TGM2

Number of citations of the paper that reports this interaction (PMID 9442029)
5

Data Source:
HPRD (in vivo, in vitro)

		EIF5A	TGM2
Gene Name		eukaryotic translation initiation factor 5A	transglutaminase 2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Annulate Lamellae Nuclear Pore Cytoplasm Endoplasmic Reticulum Membrane Cytosol Membrane Extracellular Vesicular Exosome	Mitochondrion Cytosol Plasma Membrane Focal Adhesion Extracellular Vesicular Exosome
	Molecular Function	RNA Binding Translation Elongation Factor Activity Protein Binding U6 SnRNA Binding Ribosome Binding Poly(A) RNA Binding Protein N-terminus Binding	Protein-glutamine Gamma-glutamyltransferase Activity Protein Binding GTP Binding Protein Domain Specific Binding Metal Ion Binding
	Biological Process	MRNA Export From Nucleus Translational Frameshifting Protein Export From Nucleus Nucleocytoplasmic Transport Apoptotic Process Positive Regulation Of Cell Proliferation Peptidyl-lysine Modification To Peptidyl-hypusine Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Translational Elongation Positive Regulation Of Translational Termination	Blood Vessel Remodeling Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Apoptotic Cell Clearance Positive Regulation Of Cell Adhesion Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Inflammatory Response Protein Homooligomerization Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Positive Regulation Of Mitochondrial Calcium Ion Concentration Branching Involved In Salivary Gland Morphogenesis Salivary Gland Cavitation
Pathways		Post-translational protein modification Hypusine synthesis from eIF5A-lysine Gamma carboxylation, hypusine formation and arylsulfatase activation
Drugs			Guanosine-5\'-Diphosphate
Diseases
GWAS
Protein-Protein Interactions		11 interactors: CRX DHPS DOHH MEOX2 REL RPL5 STUB1 TGM2 XPO1 XPO4 XRN2	55 interactors: A2M ABCA1 ACTB ADAR ALDOA ANKRD28 ANXA1 APP ATF4 BNIP3 C3 CASP3 COL4A3BP CSNK2A2 EIF5A FN1 FNTA GCGR GRN GSTP1 HIST1H2BG HIST2H2BE HNRNPF HNRNPUL1 HP HSPA1A HSPA1B HSPA8 HTT ITGB1 ITGB3 KPNA3 KPNA4 LTBP1 MAP3K12 PAK1 PLCD1 PPHLN1 RB1 RELA RHOA S100A7 SERPINF2 SERTAD1 SIPA1L2 SLC7A9 SMAD2 SMAD3 SPARC SUMO1 TAB2 TMEM176A TMSB4X TUBB ZNF512B
Entrez ID		1984	7052
HPRD ID		02555	01825
Ensembl ID		ENSG00000132507	ENSG00000198959
Uniprot IDs		P63241	B4DIT7 F5H6P0 P21980
PDB IDs		1FH4 3CPF	1FAU 1KV3 2Q3Z 3LY6 3S3J 3S3P 3S3S
Enriched GO Terms of Interacting Partners?		Peptidyl-lysine Modification To Peptidyl-hypusine Gene Expression Regulation Of Protein Export From Nucleus Peptidyl-lysine Modification Deoxyhypusine Biosynthetic Process From Spermidine Positive Regulation Of Photoreceptor Cell Differentiation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Chaperone-mediated Protein Complex Assembly Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Spermidine Catabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Ribosomal Small Subunit Export From Nucleus Transforming Growth Factor Beta Receptor Signaling Pathway Biosynthetic Process Polyamine Catabolic Process Somite Specification Salivary Gland Cavitation Cellular Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process RNA Biosynthetic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Macromolecule Biosynthetic Process Ubiquitin-dependent SMAD Protein Catabolic Process RNA Catabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Ribosome Biogenesis Viral Life Cycle Response To Transforming Growth Factor Beta Ribosomal Large Subunit Export From Nucleus Post-translational Protein Modification Positive Regulation Of Mitochondrial Calcium Ion Concentration Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Regulation Of Nucleocytoplasmic Transport Ribosomal Subunit Export From Nucleus Nitrogen Compound Metabolic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Interleukin-12 Biosynthetic Process Regulation Of Glucocorticoid Metabolic Process Protein Homooligomerization Regulation Of Intracellular Protein Transport Cellular Macromolecule Catabolic Process Transcription From RNA Polymerase II Promoter Misfolded Or Incompletely Synthesized Protein Catabolic Process Positive Regulation Of Protein Export From Nucleus Cellular Response To Misfolded Protein Catabolic Process	Response To Stress Response To External Stimulus Response To Stimulus Secretion By Cell Establishment Of Localization In Cell Platelet Degranulation Secretion Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Cellular Localization Positive Regulation Of Metabolic Process Platelet Activation Regulation Of Cell Proliferation Response To Wounding Regulation Of Signal Transduction Response To Other Organism Positive Regulation Of Cellular Metabolic Process Wound Healing Response To Biotic Stimulus Immune System Process Response To Oxidative Stress Blood Coagulation Response To Organic Substance Hemostasis Regulation Of Cellular Process Regulation Of Signaling Regulation Of Cellular Component Organization Defense Response Regulation Of Phosphorus Metabolic Process Regulation Of Immune System Process Cellular Response To Stimulus Cell Activation Regulation Of Catalytic Activity Signal Transduction Signaling Exocytosis Regulation Of Body Fluid Levels Positive Regulation Of Protein Metabolic Process Cell Communication Negative Regulation Of Protein Metabolic Process Cellular Response To Organic Substance Positive Regulation Of Cellular Protein Metabolic Process Cell Surface Receptor Signaling Pathway Regulation Of Phosphorylation Regulation Of Metabolic Process Viral Process Viral Entry Into Host Cell Entry Into Host Cell Regulation Of Protein Phosphorylation Response To Abiotic Stimulus
Tagcloud ?		abundant antisense approaching beginning broader cdnas cloning considerably coordinated coordinately determining eif2 eif2b eif4a eif4f emerging focuses generates initiation insight investigators machinery manipulate moderately polypeptides preferential probes repression ribosomes	antral atresia atretic bga build categorized cattle cct2 cyp11a1 cyp19a1 dab2 dairy dsg2 e2f1 follicle follicles follicular granulosa hybridized microarrays offers oocyte originating phases plateau segregation steroidogenesis transcriptomic ultimately
Tagcloud (Difference) ?		abundant antisense approaching beginning broader cdnas cloning considerably coordinated coordinately determining eif2 eif2b eif4a eif4f emerging focuses generates initiation insight investigators machinery manipulate moderately polypeptides preferential probes repression ribosomes	antral atresia atretic bga build categorized cattle cct2 cyp11a1 cyp19a1 dab2 dairy dsg2 e2f1 follicle follicles follicular granulosa hybridized microarrays offers oocyte originating phases plateau segregation steroidogenesis transcriptomic ultimately
Tagcloud (Intersection) ?