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EIF5A and RPL5
Number of citations of the paper that reports this interaction (PubMedID
9465063
)
64
Data Source:
HPRD
(in vivo, two hybrid, in vitro)
EIF5A
RPL5
Description
eukaryotic translation initiation factor 5A
ribosomal protein L5
Image
GO Annotations
Cellular Component
Nucleus
Annulate Lamellae
Nuclear Pore
Cytoplasm
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Cytosol
Membrane
Synapse
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Endoplasmic Reticulum
Cytosol
Ribosome
Focal Adhesion
Membrane
Cytosolic Large Ribosomal Subunit
Cytosolic Ribosome
Protein-containing Complex
Extracellular Exosome
Ribonucleoprotein Complex
Molecular Function
RNA Binding
Translation Elongation Factor Activity
Protein Binding
U6 SnRNA Binding
Ribosome Binding
RNA Binding
MRNA 3'-UTR Binding
Structural Constituent Of Ribosome
Protein Binding
5S RRNA Binding
RRNA Binding
Ubiquitin Protein Ligase Binding
MRNA 5'-UTR Binding
Ubiquitin Ligase Inhibitor Activity
Biological Process
Translation
Translational Elongation
Tumor Necrosis Factor-mediated Signaling Pathway
Positive Regulation Of Apoptotic Process
Positive Regulation Of Translational Elongation
Positive Regulation Of Translational Termination
Positive Regulation Of Transcription By RNA Polymerase II
Cellular Response To Virus
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Ribosomal Large Subunit Assembly
Cytoplasmic Translation
RRNA Processing
Translation
Positive Regulation Of Gene Expression
Ribosomal Large Subunit Biogenesis
Positive Regulation Of Translation
Protein Stabilization
Regulation Of Signal Transduction By P53 Class Mediator
Negative Regulation Of Ubiquitin Protein Ligase Activity
Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Protein Neddylation
Pathways
Hypusine synthesis from eIF5A-lysine
L13a-mediated translational silencing of Ceruloplasmin expression
Peptide chain elongation
SRP-dependent cotranslational protein targeting to membrane
SRP-dependent cotranslational protein targeting to membrane
Viral mRNA Translation
Selenocysteine synthesis
Major pathway of rRNA processing in the nucleolus and cytosol
Formation of a pool of free 40S subunits
GTP hydrolysis and joining of the 60S ribosomal subunit
Eukaryotic Translation Termination
Regulation of expression of SLITs and ROBOs
Response of EIF2AK4 (GCN2) to amino acid deficiency
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs
Diseases
Diamond-Blackfan anemia (DBA)
GWAS
Liver enzyme levels (alkaline phosphatase) (
33972514
)
Venous thromboembolism (
31420334
)
Allergic disease (asthma, hay fever or eczema) (
29785011
)
Height (
20881960
)
Mean corpuscular hemoglobin (
32888494
)
Mean reticulocyte volume (
32888494
)
Multiple sclerosis (
17660530
19525955
)
Interacting Genes
19 interacting genes:
CRX
DHPS
DOHH
GSC2
LBX1
MEI4
MEOX2
PICK1
REL
RPL5
SDCBP
SENP1
STUB1
SUMO2
TGM2
UBE2I
XPO1
XPO4
XRN2
32 interacting genes:
BCAS2
CLK1
CSNK2A1
CSNK2B
DCC
EIF5A
ERCC6
FOXP1
HARS1
IPO13
IPO5
IPO7
KPNB1
KRT31
MAP3K14
MDM2
NVL
OGT
PDCD4
PDE4B
PPM1D
RNA5S7
RNF181
SAYSD1
SPIN1
SPP1
TNIP1
TNPO1
TP73
TSC22D1
UPF2
VHL
Entrez ID
1984
6125
HPRD ID
02555
04699
Ensembl ID
ENSG00000132507
ENSG00000122406
Uniprot IDs
P63241
A2RUM7
P46777
PDB IDs
3CPF
5DLQ
8A0E
8Y0W
4UG0
4V6X
5AJ0
5LKS
5T2C
6IP5
6IP6
6IP8
6LQM
6LSR
6LSS
6LU8
6OLE
6OLF
6OLG
6OLI
6OLZ
6OM0
6OM7
6QZP
6W6L
6XA1
6Y0G
6Y2L
6Y57
6Y6X
6Z6L
6Z6M
6Z6N
6ZM7
6ZME
6ZMI
6ZMO
7BHP
7F5S
7OW7
7QVP
7XNX
7XNY
8A3D
8BGU
8FL0
8FL2
8FL3
8FL4
8FL6
8FL7
8FL9
8FLA
8FLB
8FLC
8FLD
8FLE
8FLF
8G5Y
8G5Z
8G60
8G61
8G6J
8GLP
8IDT
8IDY
8IE3
8IFD
8IFE
8INE
8INF
8INK
8IPD
8IPX
8IPY
8IR1
8IR3
8JDJ
8JDK
8JDL
8JDM
8K2C
8OHD
8OJ0
8OJ5
8OJ8
8QFD
8QOI
8QYX
8RL2
8UKB
8XSX
8XSY
8XSZ
8Y0W
8Y0X
8YOO
8YOP
9C3H
9G8M
9GMO
Enriched GO Terms of Interacting Partners
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Regulation Of Ubiquitin-dependent Protein Catabolic Process
Presynaptic Cytosol
Postsynaptic Cytosol
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Protein Sumoylation
Regulation Of Proteolysis
Regulation Of Proteasomal Protein Catabolic Process
Nuclear Export Signal Receptor Activity
Regulation Of Transcription By RNA Polymerase II
SUMO Transferase Activity
Nucleus
Nuclear Export
DNA-binding Transcription Factor Activity
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Chromatin
Deoxyhypusine Synthase Activity
Focal Adhesion
Interleukin-5 Receptor Complex
Regulation Of Protein Catabolic Process
Peptide Dopaminyltransferase Activity
Histone Serotonyltransferase Activity
Peptide Histaminyltransferase Activity
Protein-glutamine Glutaminase Activity
Monoamine Transport
Peptide Noradrenalinyltransferase Activity
Peptide Serotonyltransferase Activity
Histone Dopaminyltransferase Activity
SUMO Conjugating Enzyme Activity
Regulation Of Protein Export From Nucleus
Protein Export From Nucleus
Positive Regulation Of Chaperone-mediated Protein Complex Assembly
Negative Regulation Of Glutamatergic Neuron Differentiation
Peptidyl-lysine Modification To Peptidyl-hypusine
Deoxyhypusine Monooxygenase Activity
Regulation Of Macromolecule Metabolic Process
Regulation Of Gene Expression
Protein Modification Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Primary Metabolic Process
Spermidine Catabolic Process
Protein Metabolic Process
Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Interleukin-5 Receptor Binding
Protein Deamination
Cellular Response To Triglyceride
Transcription Termination Site Sequence-specific DNA Binding
Nuclear Transport
Nucleocytoplasmic Transport
Protein Localization To Organelle
Protein Localization To Nucleus
Import Into Nucleus
Protein Import Into Nucleus
Nuclear Transport
Nucleocytoplasmic Transport
Nuclear Import Signal Receptor Activity
Protein Kinase CK2 Complex
Symbiont-mediated Disruption Of Host Cell PML Body
Nuclear Localization Sequence Binding
Cytosol
Nuclear Pore
Ribosomal Protein Import Into Nucleus
Regulation Of Intracellular Signal Transduction
Regulation Of Cell Communication
Establishment Of Protein Localization To Organelle
Regulation Of Signaling
Negative Regulation Of Developmental Growth
Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Nucleoplasm
Nucleus
Regulation Of Signal Transduction By P53 Class Mediator
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Signal Transduction
Negative Regulation Of Proteolysis
Negative Regulation Of Gene Expression
Double-strand Break Repair Via Classical Nonhomologous End Joining
Signal Transduction In Response To DNA Damage
Small GTPase Binding
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of DNA-templated Transcription
Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Proteasomal Protein Catabolic Process
Regulation Of RNA Biosynthetic Process
Negative Regulation Of Collateral Sprouting
Negative Regulation Of Cell Differentiation
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Negative Regulation Of Developmental Process
Nucleolus
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Cellular Response To Stress
Intracellular Protein Transport
Negative Regulation Of Intracellular Signal Transduction
Negative Regulation Of Proteolysis Involved In Protein Catabolic Process
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Tagcloud (Intersection)
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