EIF5A and XPO4

Number of citations of the paper that reports this interaction (PMID 10944119)
57

Data Source:
HPRD (in vivo, in vitro)

		EIF5A	XPO4
Gene Name		eukaryotic translation initiation factor 5A	exportin 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Annulate Lamellae Nuclear Pore Cytoplasm Endoplasmic Reticulum Membrane Cytosol Membrane Extracellular Vesicular Exosome	Nucleoplasm Cytoplasm
	Molecular Function	RNA Binding Translation Elongation Factor Activity Protein Binding U6 SnRNA Binding Ribosome Binding Poly(A) RNA Binding Protein N-terminus Binding	Protein Binding
	Biological Process	MRNA Export From Nucleus Translational Frameshifting Protein Export From Nucleus Nucleocytoplasmic Transport Apoptotic Process Positive Regulation Of Cell Proliferation Peptidyl-lysine Modification To Peptidyl-hypusine Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Translational Elongation Positive Regulation Of Translational Termination	Protein Transport Positive Regulation Of Protein Export From Nucleus
Pathways		Post-translational protein modification Hypusine synthesis from eIF5A-lysine Gamma carboxylation, hypusine formation and arylsulfatase activation
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: CRX DHPS DOHH MEOX2 REL RPL5 STUB1 TGM2 XPO1 XPO4 XRN2	3 interactors: EIF5A RAN UBQLN1
Entrez ID		1984	64328
HPRD ID		02555	18307
Ensembl ID		ENSG00000132507	ENSG00000132953
Uniprot IDs		P63241	Q9C0E2
PDB IDs		1FH4 3CPF
Enriched GO Terms of Interacting Partners?		Peptidyl-lysine Modification To Peptidyl-hypusine Gene Expression Regulation Of Protein Export From Nucleus Peptidyl-lysine Modification Deoxyhypusine Biosynthetic Process From Spermidine Positive Regulation Of Photoreceptor Cell Differentiation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Chaperone-mediated Protein Complex Assembly Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Spermidine Catabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Ribosomal Small Subunit Export From Nucleus Transforming Growth Factor Beta Receptor Signaling Pathway Biosynthetic Process Polyamine Catabolic Process Somite Specification Salivary Gland Cavitation Cellular Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process RNA Biosynthetic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Macromolecule Biosynthetic Process Ubiquitin-dependent SMAD Protein Catabolic Process RNA Catabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Ribosome Biogenesis Viral Life Cycle Response To Transforming Growth Factor Beta Ribosomal Large Subunit Export From Nucleus Post-translational Protein Modification Positive Regulation Of Mitochondrial Calcium Ion Concentration Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Regulation Of Nucleocytoplasmic Transport Ribosomal Subunit Export From Nucleus Nitrogen Compound Metabolic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Interleukin-12 Biosynthetic Process Regulation Of Glucocorticoid Metabolic Process Protein Homooligomerization Regulation Of Intracellular Protein Transport Cellular Macromolecule Catabolic Process Transcription From RNA Polymerase II Promoter Misfolded Or Incompletely Synthesized Protein Catabolic Process Positive Regulation Of Protein Export From Nucleus Cellular Response To Misfolded Protein Catabolic Process	Protein Export From Nucleus Nuclear Export Ribosomal Small Subunit Export From Nucleus Nucleocytoplasmic Transport Nuclear Transport Translational Frameshifting Positive Regulation Of Translational Termination Positive Regulation Of Translational Elongation Ribosomal Large Subunit Export From Nucleus Ribosomal Subunit Export From Nucleus Regulation Of Translational Termination Cellular Protein Complex Localization Peptidyl-lysine Modification To Peptidyl-hypusine Protein Complex Localization Cytoplasmic Transport Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Complex Disassembly Intracellular Transport Of Virus Intracellular Protein Transport Androgen Receptor Signaling Pathway Mitotic Spindle Organization Regulation Of Cellular Response To Oxidative Stress Positive Regulation Of Protein Binding MRNA Export From Nucleus Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Translation RNA Export From Nucleus Cellular Protein Localization Protein Transport Establishment Of Protein Localization
Tagcloud ?		abundant antisense approaching beginning broader cdnas cloning considerably coordinated coordinately determining eif2 eif2b eif4a eif4f emerging focuses generates initiation insight investigators machinery manipulate moderately polypeptides preferential probes repression ribosomes
Tagcloud (Difference) ?		abundant antisense approaching beginning broader cdnas cloning considerably coordinated coordinately determining eif2 eif2b eif4a eif4f emerging focuses generates initiation insight investigators machinery manipulate moderately polypeptides preferential probes repression ribosomes
Tagcloud (Intersection) ?