EIF5A and XPO4

Number of citations of the paper that reports this interaction (PubMedID 10944119)
73

Data Source:
HPRD (in vitro, in vivo)

		EIF5A	XPO4
Description		eukaryotic translation initiation factor 5A	exportin 4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Annulate Lamellae Nuclear Pore Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Synapse	Nucleus Nuclear Pore Nucleoplasm Cytoplasm Cytosol
	Molecular Function	RNA Binding Translation Elongation Factor Activity Protein Binding U6 SnRNA Binding Ribosome Binding	Nuclear Export Signal Receptor Activity Protein Binding Small GTPase Binding
	Biological Process	Translation Translational Elongation Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Translational Elongation Positive Regulation Of Translational Termination Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Virus Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator	Glycolytic Process Protein Export From Nucleus Protein Transport Positive Regulation Of Protein Export From Nucleus Nuclear Transport
Pathways		Hypusine synthesis from eIF5A-lysine
Drugs
Diseases
GWAS		Liver enzyme levels (alkaline phosphatase) ( 33972514) Venous thromboembolism ( 31420334)	Appendicular lean mass ( 33097823) General cognitive ability ( 29844566) Neuroblastoma or malignant cutaneous melanoma ( 31605138) PR interval ( 30046033 32439900)
Interacting Genes		19 interacting genes: CRX DHPS DOHH GSC2 LBX1 MEI4 MEOX2 PICK1 REL RPL5 SDCBP SENP1 STUB1 SUMO2 TGM2 UBE2I XPO1 XPO4 XRN2	4 interacting genes: EIF5A RAN RNF10 UBQLN1
Entrez ID		1984	64328
HPRD ID		02555	18307
Ensembl ID		ENSG00000132507	ENSG00000132953
Uniprot IDs		P63241	Q0VG75 Q9C0E2
PDB IDs		3CPF 5DLQ 8A0E 8Y0W
Enriched GO Terms of Interacting Partners?		Regulation Of Ubiquitin-dependent Protein Catabolic Process Presynaptic Cytosol Postsynaptic Cytosol Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Sumoylation Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Nuclear Export Signal Receptor Activity Regulation Of Transcription By RNA Polymerase II SUMO Transferase Activity Nucleus Nuclear Export DNA-binding Transcription Factor Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromatin Deoxyhypusine Synthase Activity Focal Adhesion Interleukin-5 Receptor Complex Regulation Of Protein Catabolic Process Peptide Dopaminyltransferase Activity Histone Serotonyltransferase Activity Peptide Histaminyltransferase Activity Protein-glutamine Glutaminase Activity Monoamine Transport Peptide Noradrenalinyltransferase Activity Peptide Serotonyltransferase Activity Histone Dopaminyltransferase Activity SUMO Conjugating Enzyme Activity Regulation Of Protein Export From Nucleus Protein Export From Nucleus Positive Regulation Of Chaperone-mediated Protein Complex Assembly Negative Regulation Of Glutamatergic Neuron Differentiation Peptidyl-lysine Modification To Peptidyl-hypusine Deoxyhypusine Monooxygenase Activity Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Protein Modification Process Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Spermidine Catabolic Process Protein Metabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Interleukin-5 Receptor Binding Protein Deamination Cellular Response To Triglyceride Transcription Termination Site Sequence-specific DNA Binding Nuclear Transport Nucleocytoplasmic Transport	Annulate Lamellae Positive Regulation Of Translational Elongation Positive Regulation Of Translational Termination Regulation Of Intrinsic Apoptotic Signaling Pathway Nuclear Pore RNA Nuclear Export Complex SnRNA Import Into Nucleus Pre-miRNA Export From Nucleus Mitotic Cell Cycle RNA Import Into Nucleus Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Negative Regulation Of Store-operated Calcium Channel Activity Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Translational Termination Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Ribosomal Small Subunit Export From Nucleus Pre-miRNA Binding Ribosomal Large Subunit Export From Nucleus Importin-alpha Family Protein Binding Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Schwann Cell Proliferation Regulation Of Translational Elongation Cellular Response To Mineralocorticoid Stimulus Nuclear Export Signal Receptor Activity Protein Localization To Nucleolus Ribosomal Subunit Export From Nucleus Regulation Of Toll-like Receptor 3 Signaling Pathway
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