EIF5A and DOHH

Number of citations of the paper that reports this interaction (PMID 17213197)
8

Data Source:
HPRD (in vitro)

		EIF5A	DOHH
Gene Name		eukaryotic translation initiation factor 5A	deoxyhypusine hydroxylase/monooxygenase
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Annulate Lamellae Nuclear Pore Cytoplasm Endoplasmic Reticulum Membrane Cytosol Membrane Extracellular Vesicular Exosome	Cellular_component Cytosol
	Molecular Function	RNA Binding Translation Elongation Factor Activity Protein Binding U6 SnRNA Binding Ribosome Binding Poly(A) RNA Binding Protein N-terminus Binding	Protein Binding Deoxyhypusine Monooxygenase Activity Metal Ion Binding
	Biological Process	MRNA Export From Nucleus Translational Frameshifting Protein Export From Nucleus Nucleocytoplasmic Transport Apoptotic Process Positive Regulation Of Cell Proliferation Peptidyl-lysine Modification To Peptidyl-hypusine Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Translational Elongation Positive Regulation Of Translational Termination	Peptidyl-lysine Modification To Peptidyl-hypusine Post-translational Protein Modification Cellular Protein Metabolic Process Oxidation-reduction Process
Pathways		Post-translational protein modification Hypusine synthesis from eIF5A-lysine Gamma carboxylation, hypusine formation and arylsulfatase activation	Post-translational protein modification Hypusine synthesis from eIF5A-lysine Gamma carboxylation, hypusine formation and arylsulfatase activation
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: CRX DHPS DOHH MEOX2 REL RPL5 STUB1 TGM2 XPO1 XPO4 XRN2	1 interactors: EIF5A
Entrez ID		1984	83475
HPRD ID		02555	14627
Ensembl ID		ENSG00000132507	ENSG00000129932
Uniprot IDs		P63241	Q9BU89
PDB IDs		1FH4 3CPF
Enriched GO Terms of Interacting Partners?		Peptidyl-lysine Modification To Peptidyl-hypusine Gene Expression Regulation Of Protein Export From Nucleus Peptidyl-lysine Modification Deoxyhypusine Biosynthetic Process From Spermidine Positive Regulation Of Photoreceptor Cell Differentiation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Chaperone-mediated Protein Complex Assembly Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Spermidine Catabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Ribosomal Small Subunit Export From Nucleus Transforming Growth Factor Beta Receptor Signaling Pathway Biosynthetic Process Polyamine Catabolic Process Somite Specification Salivary Gland Cavitation Cellular Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process RNA Biosynthetic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Macromolecule Biosynthetic Process Ubiquitin-dependent SMAD Protein Catabolic Process RNA Catabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Ribosome Biogenesis Viral Life Cycle Response To Transforming Growth Factor Beta Ribosomal Large Subunit Export From Nucleus Post-translational Protein Modification Positive Regulation Of Mitochondrial Calcium Ion Concentration Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Regulation Of Nucleocytoplasmic Transport Ribosomal Subunit Export From Nucleus Nitrogen Compound Metabolic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Interleukin-12 Biosynthetic Process Regulation Of Glucocorticoid Metabolic Process Protein Homooligomerization Regulation Of Intracellular Protein Transport Cellular Macromolecule Catabolic Process Transcription From RNA Polymerase II Promoter Misfolded Or Incompletely Synthesized Protein Catabolic Process Positive Regulation Of Protein Export From Nucleus Cellular Response To Misfolded Protein Catabolic Process	Positive Regulation Of Translational Termination Translational Frameshifting Positive Regulation Of Translational Elongation Regulation Of Translational Termination Peptidyl-lysine Modification To Peptidyl-hypusine Positive Regulation Of Protein Complex Disassembly Protein Export From Nucleus MRNA Export From Nucleus Positive Regulation Of Translation RNA Export From Nucleus Nuclear Export MRNA Transport Regulation Of Protein Complex Disassembly RNA Transport RNA Localization Translational Elongation Post-translational Protein Modification Peptidyl-lysine Modification Nucleocytoplasmic Transport Nuclear Transport Regulation Of Translation
Tagcloud ?		abundant antisense approaching beginning broader cdnas cloning considerably coordinated coordinately determining eif2 eif2b eif4a eif4f emerging focuses generates initiation insight investigators machinery manipulate moderately polypeptides preferential probes repression ribosomes	5a bioactivity compromise deferiprone deoxyhypusyl depleting disappear housekeeping hydroxylase hydroxylated hydroxypyridone hydroxypyridones hypusine incompletely inducibly mimosine multiplication multiply nongenerative p24 polysomes promonocytic restrict retroviral retrovirally rev spliced transit unspliced
Tagcloud (Difference) ?		abundant antisense approaching beginning broader cdnas cloning considerably coordinated coordinately determining eif2 eif2b eif4a eif4f emerging focuses generates initiation insight investigators machinery manipulate moderately polypeptides preferential probes repression ribosomes	5a bioactivity compromise deferiprone deoxyhypusyl depleting disappear housekeeping hydroxylase hydroxylated hydroxypyridone hydroxypyridones hypusine incompletely inducibly mimosine multiplication multiply nongenerative p24 polysomes promonocytic restrict retroviral retrovirally rev spliced transit unspliced
Tagcloud (Intersection) ?