GK and GPD1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		GK	GPD1
Description		glycerol kinase	glycerol-3-phosphate dehydrogenase 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane Extracellular Exosome	Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Nucleotide Binding Glycerol Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Phosphotransferase Activity, Alcohol Group As Acceptor Metal Ion Binding	Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Protein Homodimerization Activity Glycerol-3-phosphate Dehydrogenase [NAD(P)+] Activity NAD Binding Glycerol-3-phosphate Dehydrogenase (NAD+) Activity
	Biological Process	Carbohydrate Metabolic Process Glycerol Metabolic Process Glycerol-3-phosphate Metabolic Process Triglyceride Metabolic Process Triglyceride Biosynthetic Process Glycerol Catabolic Process Glycerol-3-phosphate Biosynthetic Process	Carbohydrate Metabolic Process Glycerol-3-phosphate Metabolic Process Gluconeogenesis Glycerol-3-phosphate Shuttle Positive Regulation Of Glycolytic Process Glycerol-3-phosphate Catabolic Process Cellular Response To CAMP Cellular Response To Tumor Necrosis Factor
Pathways		Triglyceride biosynthesis	Synthesis of PA
Drugs			NADH Metformin
Diseases		Glycerol kinase deficiency (GKD), including: Hyperglycerolemia; Chromosome Xp21 deletion syndrome; Adrenal hypoplasia, congenital (AHC); Duchenne muscular dystrophy (DMD)
GWAS		Cardiovascular risk factors (age interaction) ( 20838585)	Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body size at age 10 ( 32376654) Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		11 interacting genes: AOX1 APCS CLPTM1L CYP3A4 EIF4G1 FBXO28 GPD1 IPO13 NR4A1 OPLAH RXRA	7 interacting genes: FAM25A FAM25C FAM25G GK MDH1 POMP PTN
Entrez ID		2710	2819
HPRD ID		08363	00714
Ensembl ID		ENSG00000198814	ENSG00000167588
Uniprot IDs		A0A8I5KXY7 B4DH54 P32189	A0A024R138 P21695
PDB IDs			1WPQ 1X0V 1X0X 6E8Y 6E8Z 6E90 6PYP
Enriched GO Terms of Interacting Partners?		Aldehyde Oxidase Activity Identical Protein Binding NAD Binding Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Quinine 3-monooxygenase Activity Anandamide 8,9 Epoxidase Activity Vitamin D 24-hydroxylase Activity Anandamide 11,12 Epoxidase Activity 1,8-cineole 2-exo-monooxygenase Activity Anandamide 14,15 Epoxidase Activity Vitamin D3 25-hydroxylase Activity 1-alpha,25-dihydroxyvitamin D3 23-hydroxylase Activity Positive Regulation Of Eukaryotic Translation Initiation Factor 4F Complex Assembly Glycerol-3-phosphate Dehydrogenase (NAD+) Activity Glycerol-3-phosphate Dehydrogenase [NAD(P)+] Activity Glycerol-3-phosphate Catabolic Process Glycerol-3-phosphate Shuttle Nuclear Receptor Activity 5-oxoprolinase (ATP-hydrolyzing) Activity Vitamin D Biosynthetic Process Calcitriol Biosynthetic Process From Calciol Vitamin D Catabolic Process Alkaloid Catabolic Process Vitamin D Response Element Binding Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Molybdopterin Cofactor Binding Xenobiotic Metabolic Process Iron Ion Binding Negative Regulation Of Monocyte Differentiation Testosterone 6-beta-hydroxylase Activity Vitamin D3 Metabolic Process Monoterpenoid Metabolic Process Lipid Hydroxylation Caffeine Oxidase Activity Cap-dependent Translational Initiation Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Glycerol-3-phosphate Metabolic Process Non-canonical Inflammasome Complex Assembly Double-stranded DNA Binding Import Into Nucleus Detection Of Lipopolysaccharide Cellular Response To Corticotropin-releasing Hormone Stimulus Protein Import Into Nucleus Positive Regulation Of Lipoprotein Transport Regulation Of Thyroid Hormone Receptor Signaling Pathway Positive Regulation Of Vitamin D Receptor Signaling Pathway DNA Binding Domain Binding Oxidoreductase Activity Estrogen 16-alpha-hydroxylase Activity Positive Regulation Of Translation In Response To Stress	Glycerol Kinase Activity Glycerol-3-phosphate Biosynthetic Process Intermediate Filament Polymerization Diiodophenylpyruvate Reductase (NAD+) Activity (2R)-hydroxyphenylpyruvate Reductase [NAD(P)H] Activity Intermediate Filament Polymerization Or Depolymerization Dendrite Regeneration L-malate Dehydrogenase (NAD+) Activity Malate Dehydrogenase Activity Ossification Involved In Bone Remodeling Glycerol Catabolic Process Glycerol-3-phosphate Metabolic Process Malic Enzyme Activity
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