GK and OPLAH

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		GK	OPLAH
Description		glycerol kinase	5-oxoprolinase, ATP-hydrolysing
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane Extracellular Exosome	Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding Glycerol Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Phosphotransferase Activity, Alcohol Group As Acceptor Metal Ion Binding	Nucleotide Binding Catalytic Activity Protein Binding ATP Binding Hydrolase Activity 5-oxoprolinase (ATP-hydrolyzing) Activity Identical Protein Binding
	Biological Process	Carbohydrate Metabolic Process Glycerol Metabolic Process Glycerol-3-phosphate Metabolic Process Triglyceride Metabolic Process Triglyceride Biosynthetic Process Glycerol Catabolic Process Glycerol-3-phosphate Biosynthetic Process	Glutathione Metabolic Process
Pathways		Triglyceride biosynthesis	Glutathione synthesis and recycling Defective OPLAH causes OPLAHD
Drugs			Glutamic acid
Diseases		Glycerol kinase deficiency (GKD), including: Hyperglycerolemia; Chromosome Xp21 deletion syndrome; Adrenal hypoplasia, congenital (AHC); Duchenne muscular dystrophy (DMD)
GWAS		Cardiovascular risk factors (age interaction) ( 20838585)	Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Mean spheric corpuscular volume ( 32888494) Metabolic traits ( 21886157) Serum metabolite concentrations in chronic kidney disease ( 33838163) Serum metabolite levels ( 23093944 33031748)
Interacting Genes		11 interacting genes: AOX1 APCS CLPTM1L CYP3A4 EIF4G1 FBXO28 GPD1 IPO13 NR4A1 OPLAH RXRA	6 interacting genes: GK HOXA1 POU6F2 TPK1 UBC ZNF451
Entrez ID		2710	26873
HPRD ID		08363	14880
Ensembl ID		ENSG00000198814	ENSG00000178814
Uniprot IDs		A0A8I5KXY7 B4DH54 P32189	O14841
PDB IDs
Enriched GO Terms of Interacting Partners?		Aldehyde Oxidase Activity Identical Protein Binding NAD Binding Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Quinine 3-monooxygenase Activity Anandamide 8,9 Epoxidase Activity Vitamin D 24-hydroxylase Activity Anandamide 11,12 Epoxidase Activity 1,8-cineole 2-exo-monooxygenase Activity Anandamide 14,15 Epoxidase Activity Vitamin D3 25-hydroxylase Activity 1-alpha,25-dihydroxyvitamin D3 23-hydroxylase Activity Positive Regulation Of Eukaryotic Translation Initiation Factor 4F Complex Assembly Glycerol-3-phosphate Dehydrogenase (NAD+) Activity Glycerol-3-phosphate Dehydrogenase [NAD(P)+] Activity Glycerol-3-phosphate Catabolic Process Glycerol-3-phosphate Shuttle Nuclear Receptor Activity 5-oxoprolinase (ATP-hydrolyzing) Activity Vitamin D Biosynthetic Process Calcitriol Biosynthetic Process From Calciol Vitamin D Catabolic Process Alkaloid Catabolic Process Vitamin D Response Element Binding Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Molybdopterin Cofactor Binding Xenobiotic Metabolic Process Iron Ion Binding Negative Regulation Of Monocyte Differentiation Testosterone 6-beta-hydroxylase Activity Vitamin D3 Metabolic Process Monoterpenoid Metabolic Process Lipid Hydroxylation Caffeine Oxidase Activity Cap-dependent Translational Initiation Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Glycerol-3-phosphate Metabolic Process Non-canonical Inflammasome Complex Assembly Double-stranded DNA Binding Import Into Nucleus Detection Of Lipopolysaccharide Cellular Response To Corticotropin-releasing Hormone Stimulus Protein Import Into Nucleus Positive Regulation Of Lipoprotein Transport Regulation Of Thyroid Hormone Receptor Signaling Pathway Positive Regulation Of Vitamin D Receptor Signaling Pathway DNA Binding Domain Binding Oxidoreductase Activity Estrogen 16-alpha-hydroxylase Activity Positive Regulation Of Translation In Response To Stress	Glycerol Kinase Activity Glycerol-3-phosphate Biosynthetic Process Semicircular Canal Formation UTP Thiamine Diphosphokinase Activity Thiamine Binding Thiamine Diphosphokinase Activity Abducens Nerve Formation Optokinetic Behavior Glycerol Catabolic Process Glycerol-3-phosphate Metabolic Process Thiamine Diphosphate Metabolic Process Thiamine Diphosphate Biosynthetic Process Thiamine Metabolic Process Mitochondrial Outer Membrane Negative Regulation Of Transcription Initiation By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Initiation Thiamine-containing Compound Metabolic Process Embryonic Neurocranium Morphogenesis Outer Ear Morphogenesis Regulation Of Pyruvate Decarboxylation To Acetyl-CoA Regulation Of Acyl-CoA Biosynthetic Process Alcohol Metabolic Process Phosphotransferase Activity, Alcohol Group As Acceptor DNA-binding Transcription Factor Activity, RNA Polymerase II-specific SUMO Ligase Activity Glycerol Metabolic Process Protein Tag Activity Triglyceride Biosynthetic Process
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