GK and APCS

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		GK	APCS
Description		glycerol kinase	amyloid P component, serum
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane Extracellular Exosome	Extracellular Region Extracellular Space Nucleus Extracellular Exosome Blood Microparticle
	Molecular Function	Nucleotide Binding Glycerol Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Phosphotransferase Activity, Alcohol Group As Acceptor Metal Ion Binding	Complement Component C1q Complex Binding Calcium Ion Binding Protein Binding Carbohydrate Binding Identical Protein Binding Virion Binding Metal Ion Binding Unfolded Protein Binding
	Biological Process	Carbohydrate Metabolic Process Glycerol Metabolic Process Glycerol-3-phosphate Metabolic Process Triglyceride Metabolic Process Triglyceride Biosynthetic Process Glycerol Catabolic Process Glycerol-3-phosphate Biosynthetic Process	Negative Regulation Of Acute Inflammatory Response Protein Folding Acute-phase Response Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Innate Immune Response Negative Regulation Of Monocyte Differentiation Host-mediated Suppression Of Symbiont Invasion Negative Regulation Of Viral Process Chaperone-mediated Protein Complex Assembly Negative Regulation Of Wound Healing Negative Regulation Of Glycoprotein Metabolic Process
Pathways		Triglyceride biosynthesis	Amyloid fiber formation
Drugs			Zinc Methyl 4,6-O-[(1R)-1-carboxyethylidene]-beta-D-galactopyranoside Bis-1,2-{[(Z)-2-carboxy-2-methyl-1,3-dioxane]-5-yloxycarbamoyl}-ethane BIS-1,2-{[(Z)-2CARBOXY-2-METHYL-1,3-DIOXANE]-5-YLOXYCARBONYL}-PIPERAZINE Copper Zinc acetate
Diseases		Glycerol kinase deficiency (GKD), including: Hyperglycerolemia; Chromosome Xp21 deletion syndrome; Adrenal hypoplasia, congenital (AHC); Duchenne muscular dystrophy (DMD)
GWAS		Cardiovascular risk factors (age interaction) ( 20838585)	Blood protein levels ( 30072576) C-reactive protein ( 22939635) Neonatal white matter microstructure ( 33009551)
Interacting Genes		11 interacting genes: AOX1 APCS CLPTM1L CYP3A4 EIF4G1 FBXO28 GPD1 IPO13 NR4A1 OPLAH RXRA	18 interacting genes: ALX1 C1QA C4BPA CALU COL4A1 COPS5 CRP FCGR1A FCGR2B FCGR3A FCGR3B FN1 GK GOT2 GRB2 HES1 LAMA1 TG
Entrez ID		2710	325
HPRD ID		08363	00101
Ensembl ID		ENSG00000198814	ENSG00000132703
Uniprot IDs		A0A8I5KXY7 B4DH54 P32189	P02743 V9HWP0
PDB IDs			1GYK 1LGN 1SAC 2A3W 2A3X 2A3Y 2W08 3D5O 3KQR 4AVS 4AVT 4AVV 4AYU
Enriched GO Terms of Interacting Partners?		Aldehyde Oxidase Activity Identical Protein Binding NAD Binding Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Quinine 3-monooxygenase Activity Anandamide 8,9 Epoxidase Activity Vitamin D 24-hydroxylase Activity Anandamide 11,12 Epoxidase Activity 1,8-cineole 2-exo-monooxygenase Activity Anandamide 14,15 Epoxidase Activity Vitamin D3 25-hydroxylase Activity 1-alpha,25-dihydroxyvitamin D3 23-hydroxylase Activity Positive Regulation Of Eukaryotic Translation Initiation Factor 4F Complex Assembly Glycerol-3-phosphate Dehydrogenase (NAD+) Activity Glycerol-3-phosphate Dehydrogenase [NAD(P)+] Activity Glycerol-3-phosphate Catabolic Process Glycerol-3-phosphate Shuttle Nuclear Receptor Activity 5-oxoprolinase (ATP-hydrolyzing) Activity Vitamin D Biosynthetic Process Calcitriol Biosynthetic Process From Calciol Vitamin D Catabolic Process Alkaloid Catabolic Process Vitamin D Response Element Binding Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Molybdopterin Cofactor Binding Xenobiotic Metabolic Process Iron Ion Binding Negative Regulation Of Monocyte Differentiation Testosterone 6-beta-hydroxylase Activity Vitamin D3 Metabolic Process Monoterpenoid Metabolic Process Lipid Hydroxylation Caffeine Oxidase Activity Cap-dependent Translational Initiation Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Glycerol-3-phosphate Metabolic Process Non-canonical Inflammasome Complex Assembly Double-stranded DNA Binding Import Into Nucleus Detection Of Lipopolysaccharide Cellular Response To Corticotropin-releasing Hormone Stimulus Protein Import Into Nucleus Positive Regulation Of Lipoprotein Transport Regulation Of Thyroid Hormone Receptor Signaling Pathway Positive Regulation Of Vitamin D Receptor Signaling Pathway DNA Binding Domain Binding Oxidoreductase Activity Estrogen 16-alpha-hydroxylase Activity Positive Regulation Of Translation In Response To Stress	IgG Binding IgG Receptor Activity Acute Inflammatory Response Antibody-dependent Cellular Cytotoxicity Hypersensitivity Acute Inflammatory Response To Antigenic Stimulus Lymphocyte Mediated Immunity Immune Effector Process Leukocyte Mediated Immunity Leukocyte Mediated Cytotoxicity Fc-gamma Receptor Signaling Pathway Inflammatory Response To Antigenic Stimulus Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Fc Receptor Signaling Pathway Low-affinity IgG Receptor Activity Cell Killing Defense Response Response To Other Organism Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune System Process Adaptive Immune Response Extracellular Region Immune Response Inflammatory Response Retinal Blood Vessel Morphogenesis Response To External Biotic Stimulus Regulation Of Immune Response Innate Immune Response Immune System Process Positive Regulation Of Immune System Process Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Regulation Of Lymphocyte Mediated Immunity Retina Vasculature Morphogenesis In Camera-type Eye Immune Response-regulating Signaling Pathway Cell Surface Receptor Signaling Pathway Defense Response To Symbiont Defense Response To Other Organism Basement Membrane Regulation Of Mononuclear Cell Proliferation Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Regulation Of Acute Inflammatory Response To Antigenic Stimulus Renal Tubule Morphogenesis Blood Vessel Morphogenesis Regulation Of Leukocyte Proliferation Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Leukocyte Activation Extracellular Matrix Structural Constituent
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