GK and CLPTM1L

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		GK	CLPTM1L
Description		glycerol kinase	CLPTM1 like
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane Extracellular Exosome	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endomembrane System Membrane
	Molecular Function	Nucleotide Binding Glycerol Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Phosphotransferase Activity, Alcohol Group As Acceptor Metal Ion Binding	Protein Binding Phospholipid Scramblase Activity
	Biological Process	Carbohydrate Metabolic Process Glycerol Metabolic Process Glycerol-3-phosphate Metabolic Process Triglyceride Metabolic Process Triglyceride Biosynthetic Process Glycerol Catabolic Process Glycerol-3-phosphate Biosynthetic Process	Lipid Transport Apoptotic Process Plasma Membrane Phospholipid Scrambling
Pathways		Triglyceride biosynthesis
Drugs
Diseases		Glycerol kinase deficiency (GKD), including: Hyperglycerolemia; Chromosome Xp21 deletion syndrome; Adrenal hypoplasia, congenital (AHC); Duchenne muscular dystrophy (DMD)
GWAS		Cardiovascular risk factors (age interaction) ( 20838585)	Adenocarcinoma in never smokers ( 31009812) Basal cell carcinoma ( 19151717 33549134 27539887) Benign prostatic hyperplasia and lower urinary tract symptoms ( 30410027) Bladder cancer ( 20972438) Cervical intraepithelial neoplasia grade 3 and invasive cervical cancer ( 33794208) Chronic lymphocytic leukemia ( 24292274) Colorectal cancer or advanced adenoma ( 30510241) Cutaneous malignant melanoma ( 32341527) Cutaneous melanoma or hair colour ( 32341527) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Lung adenocarcinoma ( 19836008 20700438) Lung cancer ( 18978790 28604730 18978787 19654303) Lung cancer in ever smokers ( 28604730) Lung cancer in never smokers ( 31009812) Melanoma ( 21983787) Nasopharyngeal carcinoma ( 26545403 27436580) Nevus count or cutaneous melanoma ( 32341527) Non-melanoma skin cancer ( 29739929) Oral cavity cancer ( 27749845 32276964) Pancreatic cancer ( 26098869 20101243 25086665 29422604 27579533) Prostate-specific antigen levels ( 30410027 28139693) Squamous cell lung carcinoma ( 28604730) Testicular germ cell cancer ( 20543847) Testicular germ cell tumor ( 23666240 28604732) Uveal melanoma ( 28781888)
Interacting Genes		11 interacting genes: AOX1 APCS CLPTM1L CYP3A4 EIF4G1 FBXO28 GPD1 IPO13 NR4A1 OPLAH RXRA	3 interacting genes: ADRB2 GK KCNF1
Entrez ID		2710	81037
HPRD ID		08363	07480
Ensembl ID		ENSG00000198814	ENSG00000049656
Uniprot IDs		A0A8I5KXY7 B4DH54 P32189	Q96KA5
PDB IDs
Enriched GO Terms of Interacting Partners?		Aldehyde Oxidase Activity Identical Protein Binding NAD Binding Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Quinine 3-monooxygenase Activity Anandamide 8,9 Epoxidase Activity Vitamin D 24-hydroxylase Activity Anandamide 11,12 Epoxidase Activity 1,8-cineole 2-exo-monooxygenase Activity Anandamide 14,15 Epoxidase Activity Vitamin D3 25-hydroxylase Activity 1-alpha,25-dihydroxyvitamin D3 23-hydroxylase Activity Positive Regulation Of Eukaryotic Translation Initiation Factor 4F Complex Assembly Glycerol-3-phosphate Dehydrogenase (NAD+) Activity Glycerol-3-phosphate Dehydrogenase [NAD(P)+] Activity Glycerol-3-phosphate Catabolic Process Glycerol-3-phosphate Shuttle Nuclear Receptor Activity 5-oxoprolinase (ATP-hydrolyzing) Activity Vitamin D Biosynthetic Process Calcitriol Biosynthetic Process From Calciol Vitamin D Catabolic Process Alkaloid Catabolic Process Vitamin D Response Element Binding Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Molybdopterin Cofactor Binding Xenobiotic Metabolic Process Iron Ion Binding Negative Regulation Of Monocyte Differentiation Testosterone 6-beta-hydroxylase Activity Vitamin D3 Metabolic Process Monoterpenoid Metabolic Process Lipid Hydroxylation Caffeine Oxidase Activity Cap-dependent Translational Initiation Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Glycerol-3-phosphate Metabolic Process Non-canonical Inflammasome Complex Assembly Double-stranded DNA Binding Import Into Nucleus Detection Of Lipopolysaccharide Cellular Response To Corticotropin-releasing Hormone Stimulus Protein Import Into Nucleus Positive Regulation Of Lipoprotein Transport Regulation Of Thyroid Hormone Receptor Signaling Pathway Positive Regulation Of Vitamin D Receptor Signaling Pathway DNA Binding Domain Binding Oxidoreductase Activity Estrogen 16-alpha-hydroxylase Activity Positive Regulation Of Translation In Response To Stress	Potassium Channel Regulator Activity Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Positive Regulation Of Mini Excitatory Postsynaptic Potential Glycerol Kinase Activity Glycerol-3-phosphate Biosynthetic Process Beta2-adrenergic Receptor Activity Response To Psychosocial Stress Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Beta-adrenergic Receptor Activity Norepinephrine Binding Positive Regulation Of Lipophagy AMPA Selective Glutamate Receptor Signaling Pathway Glycerol Catabolic Process Glycerol-3-phosphate Metabolic Process Positive Regulation Of Autophagosome Maturation Regulation Of Metal Ion Transport Heat Generation Adrenergic Receptor Activity Diet Induced Thermogenesis Regulation Of Monoatomic Ion Transport Regulation Of Membrane Potential Adenylate Cyclase Binding Negative Regulation Of Smooth Muscle Contraction Phosphotransferase Activity, Alcohol Group As Acceptor Negative Regulation Of Multicellular Organism Growth Glycerol Metabolic Process Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Autophagosome Maturation Positive Regulation Of CAMP/PKA Signal Transduction Triglyceride Biosynthetic Process Negative Regulation Of Muscle Contraction Neuronal Dense Core Vesicle Adrenergic Receptor Signaling Pathway Negative Regulation Of Systemic Arterial Blood Pressure Adaptive Thermogenesis Bone Resorption Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Brown Fat Cell Differentiation Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Excitatory Postsynaptic Potential Alcohol Catabolic Process Temperature Homeostasis Positive Regulation Of Protein-containing Complex Disassembly Response To Cold Ligand-gated Ion Channel Signaling Pathway Positive Regulation Of Bone Mineralization Ciliary Base Regulation Of Systemic Arterial Blood Pressure Regulation Of CAMP/PKA Signal Transduction Negative Regulation Of Blood Pressure
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