WARS1 and DCAF13

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		WARS1	DCAF13
Description		tryptophanyl-tRNA synthetase 1	DDB1 and CUL4 associated factor 13
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Protein-containing Complex Extracellular Exosome	Nucleus Nucleoplasm Nucleolus Centrosome Cytosol Cell Junction Small-subunit Processome Cul4-RING E3 Ubiquitin Ligase Complex Ribonucleoprotein Complex
	Molecular Function	Nucleotide Binding Aminoacyl-tRNA Ligase Activity Tryptophan-tRNA Ligase Activity Protein Binding ATP Binding Ligase Activity Kinase Inhibitor Activity Protein Kinase Binding Protein Domain Specific Binding Protein Homodimerization Activity	RNA Binding Protein Binding Nuclear Estrogen Receptor Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Angiogenesis Translation TRNA Aminoacylation For Protein Translation Tryptophanyl-tRNA Aminoacylation Negative Regulation Of Protein Kinase Activity Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Protein-containing Complex Assembly Regulation Of Angiogenesis	Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Oocyte Growth RRNA Processing Spindle Assembly Involved In Female Meiosis Female Gamete Generation Protein Ubiquitination Ribosome Biogenesis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Epigenetic Programming In The Zygotic Pronuclei Decidualization Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Pathways		Cytosolic tRNA aminoacylation	rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol Neddylation
Drugs		Tryptophan Tryptophanyl-5'amp Tryptophanamide
Diseases
GWAS
Interacting Genes		15 interacting genes: APP CDK2AP2 CEBPA DCAF13 DNMT3B DSCAM EEF1A1 FILNC1 LCOR LIG4 LINC01554 MDH2 OGT TERF1 UBC	4 interacting genes: PTEN TK1 USP2-AS1 WARS1
Entrez ID		7453	25879
HPRD ID		01845	08528
Ensembl ID		ENSG00000140105	ENSG00000164934
Uniprot IDs		A0A024R6K8 P23381	A0A087WT20 Q9NV06
PDB IDs		1O5T 1R6T 1R6U 1ULH 2AKE 2AZX 2DR2 2QUH 2QUI 2QUJ 2QUK 5UJI 5UJJ	7MQ8 7MQ9 7MQA
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Proteolysis Amyloid-beta Complex Growth Cone Lamellipodium Central Nervous System Development Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Protein Catabolic Process Neuron Recognition Nucleus Cellular Response To Metal Ion Response To Lithium Ion Cellular Response To Lithium Ion RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding DNA (cytosine-5-)-methyltransferase Activity, Acting On CpG Substrates Establishment Of Integrated Proviral Latency L-malate Dehydrogenase (NADP+) Activity Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Nuclear Estrogen Receptor Binding Regulation Of Glycolytic Process Negative Regulation Of Transcription By RNA Polymerase II Acetylcholine Receptor Activator Activity PTB Domain Binding Regulation Of ATP Metabolic Process Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Carbohydrate Catabolic Process Regulation Of Purine Nucleotide Metabolic Process Endosome To Plasma Membrane Transport Vesicle Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Chromatin DNA Binding CHOP-C/EBP Complex Stem Cell Proliferation Response To Vitamin B2 C/EBP Complex DNA-methyltransferase Activity DNA (cytosine-5-)-methyltransferase Activity Post-embryonic Retina Morphogenesis In Camera-type Eye	Negative Regulation Of Synaptic Vesicle Clustering Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Central Nervous System Myelin Maintenance Negative Regulation Of Phosphorylation Negative Regulation Of Protein Phosphorylation Rhythmic Synaptic Transmission Negative Regulation Of Phosphate Metabolic Process Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity DNA Synthesis Involved In Mitotic DNA Replication Thymidine Kinase Activity Tryptophan-tRNA Ligase Activity Tryptophanyl-tRNA Aminoacylation Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Myelin Sheath Adaxonal Region Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Phosphatidylinositol Phosphate Phosphatase Activity Thymidine Biosynthetic Process MCRD-mediated MRNA Stability Complex Negative Regulation Of Peptidyl-serine Phosphorylation Regulation Of Synaptic Vesicle Clustering Postsynaptic Density Assembly Thymidine Metabolic Process Kinase Inhibitor Activity Locomotor Rhythm Phosphatidylinositol-3-phosphate Phosphatase Activity Cellular Response To Electrical Stimulus Ubiquitin Ligase Activator Activity Spindle Assembly Involved In Female Meiosis Postsynaptic Specialization Assembly Prepulse Inhibition Neuron-neuron Synaptic Transmission Negative Regulation Of Cell Size Maternal Behavior Presynaptic Membrane Organization Schmidt-Lanterman Incisure Anaphase-promoting Complex Binding Forebrain Morphogenesis Negative Regulation Of Excitatory Postsynaptic Potential Presynaptic Membrane Assembly Pyrimidine Nucleoside Metabolic Process Deoxyribonucleoside Monophosphate Biosynthetic Process Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Translation Activator Activity Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay CRD-mediated MRNA Stabilization Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
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