AGTR2 and SNTA1

Number of citations of the paper that reports this interaction (PubMedID 15123239)
0

Data Source:
BioGRID (unspecified method)

		AGTR2	SNTA1
Description		angiotensin II receptor type 2	syntrophin alpha 1
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Cytoplasm Cytoskeleton Plasma Membrane Dystrophin-associated Glycoprotein Complex Syntrophin Complex Membrane Lateral Plasma Membrane Neuromuscular Junction Protein-containing Complex Sarcolemma Anchoring Junction
	Molecular Function	G Protein-coupled Receptor Activity Angiotensin Type II Receptor Activity Protein Binding Receptor Antagonist Activity	Actin Binding Structural Molecule Activity Protein Binding Calmodulin Binding Sodium Channel Regulator Activity PDZ Domain Binding Transmembrane Transporter Binding Nitric-oxide Synthase Binding ATPase Binding
	Biological Process	Blood Vessel Remodeling Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Angiotensin-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Brain Renin-angiotensin System Inflammatory Response Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Brain Development Regulation Of Blood Pressure Negative Regulation Of Heart Rate Negative Regulation Of Cell Growth Regulation Of Metanephros Size Exploration Behavior Nitric Oxide-cGMP-mediated Signaling Angiotensin-activated Signaling Pathway Vasodilation Regulation Of Apoptotic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of DNA-templated Transcription Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Neuron Apoptotic Process Positive Regulation Of Metanephric Glomerulus Development Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Blood Vessel Diameter Maintenance Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Regulation Of Heart Rate Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Ventricular Cardiac Muscle Cell Action Potential Regulation Of Sodium Ion Transmembrane Transport
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events	Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)
Drugs		Tasosartan CYT006-AngQb Olodanrigan
Diseases		Non-syndromic X-linked mental retardation	Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)
GWAS		Cystic fibrosis severity ( 21602797) Gestational age at birth (maternal effect) ( 28877031) Lung disease severity in cystic fibrosis ( 26417704) Offspring birth weight ( 31043758) Preterm birth (maternal effect) ( 28877031) Type 2 diabetes ( 29358691 30130595)	HDL cholesterol x physical activity interaction (1df test) ( 30670697) HDL cholesterol x physical activity interaction (2df test) ( 30670697)
Interacting Genes		13 interacting genes: ACE ACE2 AGT AGTRAP ARRB2 ERBB3 ERBIN GNAI2 GNAI3 MTUS1 PIK3CB SNTA1 ZBTB16	76 interacting genes: ABCA1 ABCC4 ACTA2 ADAMTS6 ADGRB1 ADGRB2 ADGRB3 ADH5 ADRA1D ADRA2A ADRB1 AGTR2 ATP2B2 ATP6V0B C3AR1 CALM1 CD3E CNKSR2 COPB1 DGKZ DMD DTNA DTNB ENTREP3 F8A1 FABP1 GDA GLS GLS2 GOLGA2 GRB2 GUCY1A2 HTR2B HTR2C IL2RA IL9 ITGB5 KCNA4 KCNA5 KCNJ10 KCNJ12 KCNJ15 KCNJ4 KIF1B LMO1 MAP4 MAPK12 MAS1 MAST1 MCM7 MED8 MTMR2 NAT1 NMU NOS1 PFN2 PRLHR PSKH1 RPS6KA1 SCN1A SCN4A SCN5A SCTR SLC16A7 SLC1A7 SLC2A3 SLC6A3 SSTR1 TGFA TIAM1 TLX3 TRA TRBV12-3 UTRN VANGL2 XRCC6
Entrez ID		186	6640
HPRD ID		02071	03009
Ensembl ID		ENSG00000180772	ENSG00000101400
Uniprot IDs		P50052	B3KTR0 Q13424
PDB IDs		5UNF 5UNG 5UNH 5XJM 6JOD 7C6A 7JNI
Enriched GO Terms of Interacting Partners?		Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Regulation Of Gap Junction Assembly Angiotensin-activated Signaling Pathway Type 2 Angiotensin Receptor Binding Peptidyl-dipeptidase Activity Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Regulation Of Renal Output By Angiotensin Regulation Of Systemic Arterial Blood Pressure Regulation Of MAPK Cascade Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Regulation Of Blood Pressure Regulation Of Blood Volume By Renin-angiotensin Positive Regulation Of Gap Junction Assembly G Protein-coupled Receptor Signaling Pathway Regulation Of Heart Contraction Regulation Of Vasoconstriction Positive Regulation Of Reactive Oxygen Species Metabolic Process Plasma Membrane G Protein-coupled Receptor Binding Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Signal Transduction Regulation Of Blood Circulation Angiotensin Maturation Regulation Of System Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Multicellular Organismal Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Transport Guanyl Nucleotide Binding Renal System Process Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Superoxide Anion Generation Regulation Of Superoxide Anion Generation G-protein Beta/gamma-subunit Complex Binding Regulation Of Reactive Oxygen Species Metabolic Process Metallocarboxypeptidase Activity Negative Regulation Of Intracellular Signal Transduction Regulation Of Biological Quality Regulation Of Cardiac Conduction Blood Vessel Diameter Maintenance Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Tube Size Regulation Of Superoxide Metabolic Process Negative Regulation Of Catalytic Activity Carboxypeptidase Activity Negative Regulation Of MAPK Cascade Kidney Development Regulation Of Intracellular Signal Transduction Sodium Channel Regulator Activity	Plasma Membrane System Process Regulation Of System Process Membrane G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Regulation Of Blood Circulation Circulatory System Process Vascular Process In Circulatory System Monoatomic Ion Channel Complex Regulation Of Multicellular Organismal Process Regulation Of Heart Contraction Blood Vessel Diameter Maintenance Regulation Of Tube Size Basolateral Plasma Membrane Monoatomic Ion Transmembrane Transport Regulation Of Biological Quality Transmembrane Transport Muscle Contraction Inorganic Ion Transmembrane Transport Metal Ion Transport Monoatomic Ion Transport Regulation Of Heart Rate Inorganic Cation Transmembrane Transport Regulation Of Membrane Potential Monoatomic Cation Transmembrane Transport Monoatomic Cation Transport Cardiac Muscle Cell Action Potential Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Muscle System Process Synapse Inward Rectifier Potassium Channel Activity Synaptic Signaling Vasodilation Intracellular Signaling Cassette Regulation Of Monoatomic Ion Transmembrane Transport Adrenergic Receptor Activity CGMP-mediated Signaling Calcium-mediated Signaling Action Potential Potassium Ion Transport Regulation Of Blood Pressure Regulation Of Muscle Contraction Regulation Of Monoatomic Ion Transport Voltage-gated Sodium Channel Complex Signal Transduction Angiotensin-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Multicellular Organismal Process
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