DRD5 and GNA13

Number of citations of the paper that reports this interaction (PMID 12623966)
22

Data Source:
HPRD (in vivo)

		DRD5	GNA13
Gene Name		dopamine receptor D5	guanine nucleotide binding protein (G protein), alpha 13
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Brush Border Membrane	Nucleus Heterotrimeric G-protein Complex Plasma Membrane Focal Adhesion Membrane Brush Border Membrane Melanosome Extracellular Vesicular Exosome
	Molecular Function	Dopamine Neurotransmitter Receptor Activity, Coupled Via Gs Dopamine Neurotransmitter Receptor Activity Dopamine Binding	GTPase Activity Signal Transducer Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding Type 1 Angiotensin Receptor Binding D5 Dopamine Receptor Binding Metal Ion Binding
	Biological Process	Synaptic Transmission, Dopaminergic Response To Amphetamine Regulation Of Systemic Arterial Blood Pressure By Vasopressin Norepinephrine-epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Cellular Calcium Ion Homeostasis Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Synaptic Transmission Associative Learning Positive Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Transmission Of Nerve Impulse Negative Regulation Of NAD(P)H Oxidase Activity Wound Healing Response To Cocaine Positive Regulation Of Adenylate Cyclase Activity Negative Regulation Of Blood Pressure Regulation Of Female Receptivity Sensitization Phospholipase C-activating Dopamine Receptor Signaling Pathway Long Term Synaptic Depression Cellular Response To Catecholamine Stimulus Reactive Oxygen Species Metabolic Process	Patterning Of Blood Vessels In Utero Embryonic Development Movement Of Cell Or Subcellular Component Signal Transduction Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Rho Protein Signal Transduction Blood Coagulation Regulation Of Cell Shape Cell Differentiation Platelet Activation Regulation Of Cell Migration Activation Of Phospholipase D Activity
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Dopamine receptors	Thrombin signalling through proteinase activated receptors (PARs) Signaling by GPCR GPCR downstream signaling Thromboxane signalling through TP receptor G alpha (12/13) signalling events Signal amplification Platelet activation, signaling and aggregation
Drugs		Ziprasidone Cabergoline Ropinirole Olanzapine Pramipexole Lisuride Apomorphine Fenoldopam Dopamine Carphenazine Pergolide Bromocriptine Quetiapine Levodopa Aripiprazole Methotrimeprazine Zuclopenthixol Rotigotine
Diseases
GWAS
Protein-Protein Interactions		5 interactors: GABRG2 GNA12 GNA13 GNAZ NCS1	31 interactors: AIP AKAP3 ARHGEF1 ARHGEF11 ARHGEF12 CDH1 CDH2 CTNNB1 CXCR4 DRD5 EDNRB F2R GNA12 GPR17 MCF2 MTNR1A PPP5C PRKACA PRKCB PRKCD PRKCE PTK2B RDX RGS16 RIC8A S1PR2 S1PR3 S1PR4 TBXA2R TGFBR1 TSHR
Entrez ID		1816	10672
HPRD ID		00542	05100
Ensembl ID		ENSG00000169676	ENSG00000120063
Uniprot IDs		P21918	B7Z7R0 F5H1G8 Q14344
PDB IDs
Enriched GO Terms of Interacting Partners?		Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger G-protein Coupled Receptor Signaling Pathway Rho Protein Signal Transduction Intracellular Signal Transduction Regulation Of Cell Shape Signal Transduction Platelet Activation Signaling Ras Protein Signal Transduction Cell Communication Cell Surface Receptor Signaling Pathway Cellular Response To Stimulus Cellular Response To Histamine Synaptic Transmission, GABAergic Response To Histamine Blood Coagulation Hemostasis Activation Of Phospholipase D Activity Regulation Of Cell Morphogenesis Cellular Response To Ammonium Ion In Utero Embryonic Development Regulation Of Cellular Component Organization Response To Stimulus Regulation Of Body Fluid Levels Regulation Of Cell Migration Wound Healing Gamma-aminobutyric Acid Signaling Pathway Small GTPase Mediated Signal Transduction Regulation Of Cell Motility Multicellular Organismal Development Regulation Of Fibroblast Migration Regulation Of Locomotion Cell Activation Regulation Of Cellular Component Movement Response To Wounding Chordate Embryonic Development Patterning Of Blood Vessels Embryo Development Ending In Birth Or Egg Hatching Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Developmental Process Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Regulation Of TOR Signaling Positive Regulation Of Exocytosis Neuron-neuron Synaptic Transmission Embryonic Digit Morphogenesis Positive Regulation Of Phospholipase Activity	Cell Surface Receptor Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Intracellular Signal Transduction Signal Transduction Positive Regulation Of Catalytic Activity Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis G-protein Coupled Receptor Signaling Pathway Signaling Regulation Of Signaling Cell Communication Regulation Of Catalytic Activity Regulation Of Signal Transduction Cellular Response To Stimulus Cytosolic Calcium Ion Homeostasis Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Response To Organic Substance Positive Regulation Of Cytosolic Calcium Ion Concentration Cell Activation Cellular Chemical Homeostasis Ion Homeostasis Apoptotic Process Programmed Cell Death Response To Stimulus Positive Regulation Of Hydrolase Activity Cellular Response To Organic Substance Cell Death Death Chemical Homeostasis Cellular Homeostasis Regulation Of Cellular Process G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Intracellular Signal Transduction Regulation Of Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade Platelet Activation Homeostatic Process Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Signaling Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Neurotrophin Signaling Pathway Positive Regulation Of Cellular Metabolic Process Termination Of Signal Transduction
Tagcloud ?		2j allen atlas b6 bc023892 btg3 bves edinger egr1 ew ewcp ewpg ghsr housekeeping microdissection neto1 neurogenetic neuropeptides oculomotor peptidergic postn preganglionic projecting ptprn publicly punch rcn1 ucn westphal	18q 19p13 1q aberrations arising burkitt collaborating cooperate copy deep enhancer gains id3 immunoglobulin lymphoma microrna myc next profiling recurrent scope sequencing signatures smarca4 subgroups summary transcriptome widened yielded
Tagcloud (Difference) ?		2j allen atlas b6 bc023892 btg3 bves edinger egr1 ew ewcp ewpg ghsr housekeeping microdissection neto1 neurogenetic neuropeptides oculomotor peptidergic postn preganglionic projecting ptprn publicly punch rcn1 ucn westphal	18q 19p13 1q aberrations arising burkitt collaborating cooperate copy deep enhancer gains id3 immunoglobulin lymphoma microrna myc next profiling recurrent scope sequencing signatures smarca4 subgroups summary transcriptome widened yielded
Tagcloud (Intersection) ?