DRD5 and NCS1

Number of citations of the paper that reports this interaction (PMID 12351722)
37

Data Source:
HPRD (two hybrid)

		DRD5	NCS1
Gene Name		dopamine receptor D5	neuronal calcium sensor 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Brush Border Membrane	Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Cell Junction Axon Dendrite Dense Core Granule Golgi Cisterna Membrane Intracellular Membrane-bounded Organelle Postsynaptic Membrane Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Dopamine Neurotransmitter Receptor Activity, Coupled Via Gs Dopamine Neurotransmitter Receptor Activity Dopamine Binding	Magnesium Ion Binding Voltage-gated Calcium Channel Activity Calcium Ion Binding Protein Binding Protein Kinase Binding
	Biological Process	Synaptic Transmission, Dopaminergic Response To Amphetamine Regulation Of Systemic Arterial Blood Pressure By Vasopressin Norepinephrine-epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Cellular Calcium Ion Homeostasis Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Synaptic Transmission Associative Learning Positive Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Transmission Of Nerve Impulse Negative Regulation Of NAD(P)H Oxidase Activity Wound Healing Response To Cocaine Positive Regulation Of Adenylate Cyclase Activity Negative Regulation Of Blood Pressure Regulation Of Female Receptivity Sensitization Phospholipase C-activating Dopamine Receptor Signaling Pathway Long Term Synaptic Depression Cellular Response To Catecholamine Stimulus Reactive Oxygen Species Metabolic Process	Regulation Of Neuron Projection Development Positive Regulation Of Exocytosis Phosphatidylinositol-mediated Signaling Calcium Ion Transmembrane Transport
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Dopamine receptors
Drugs		Ziprasidone Cabergoline Ropinirole Olanzapine Pramipexole Lisuride Apomorphine Fenoldopam Dopamine Carphenazine Pergolide Bromocriptine Quetiapine Levodopa Aripiprazole Methotrimeprazine Zuclopenthixol Rotigotine
Diseases
GWAS			Alzheimer's disease (cognitive decline) ( 23535033)
Protein-Protein Interactions		5 interactors: GABRG2 GNA12 GNA13 GNAZ NCS1	9 interactors: ADRBK1 DRD2 DRD3 DRD5 DTX2 IL1RAPL1 KCND2 NBL1 PI4KB
Entrez ID		1816	23413
HPRD ID		00542	04500
Ensembl ID		ENSG00000169676	ENSG00000107130
Uniprot IDs		P21918	P62166
PDB IDs			1G8I 2LCP
Enriched GO Terms of Interacting Partners?		Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger G-protein Coupled Receptor Signaling Pathway Rho Protein Signal Transduction Intracellular Signal Transduction Regulation Of Cell Shape Signal Transduction Platelet Activation Signaling Ras Protein Signal Transduction Cell Communication Cell Surface Receptor Signaling Pathway Cellular Response To Stimulus Cellular Response To Histamine Synaptic Transmission, GABAergic Response To Histamine Blood Coagulation Hemostasis Activation Of Phospholipase D Activity Regulation Of Cell Morphogenesis Cellular Response To Ammonium Ion In Utero Embryonic Development Regulation Of Cellular Component Organization Response To Stimulus Regulation Of Body Fluid Levels Regulation Of Cell Migration Wound Healing Gamma-aminobutyric Acid Signaling Pathway Small GTPase Mediated Signal Transduction Regulation Of Cell Motility Multicellular Organismal Development Regulation Of Fibroblast Migration Regulation Of Locomotion Cell Activation Regulation Of Cellular Component Movement Response To Wounding Chordate Embryonic Development Patterning Of Blood Vessels Embryo Development Ending In Birth Or Egg Hatching Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Developmental Process Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Regulation Of TOR Signaling Positive Regulation Of Exocytosis Neuron-neuron Synaptic Transmission Embryonic Digit Morphogenesis Positive Regulation Of Phospholipase Activity	Synaptic Transmission, Dopaminergic Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Dopamine Receptor Signaling Pathway Response To Amphetamine Regulation Of Locomotion Involved In Locomotory Behavior Negative Regulation Of Dopamine Receptor Signaling Pathway Receptor Internalization Negative Regulation Of Blood Pressure Response To Cocaine Response To Amine Regulation Of Adenylate Cyclase Activity Regulation Of Dopamine Receptor Signaling Pathway Regulation Of Cyclase Activity Neuron-neuron Synaptic Transmission Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Phospholipase C-activating Dopamine Receptor Signaling Pathway Receptor Metabolic Process Associative Learning Blood Circulation Regulation Of Dopamine Uptake Involved In Synaptic Transmission Regulation Of CAMP Biosynthetic Process Response To Ammonium Ion Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Receptor-mediated Endocytosis Regulation Of CAMP Metabolic Process Positive Regulation Of Renal Sodium Excretion Response To Histamine G-protein Coupled Receptor Internalization Arachidonic Acid Secretion Behavioral Response To Cocaine Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Ion Transmembrane Transport Regulation Of Neurotransmitter Uptake Prepulse Inhibition Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Learning Regulation Of Circadian Sleep/wake Cycle, Sleep Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Synaptic Transmission, Dopaminergic G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Response To Alkaloid Negative Regulation Of Secretion By Cell Regulation Of Renal Sodium Excretion Negative Regulation Of Adenylate Cyclase Activity Regulation Of Dopamine Secretion Negative Regulation Of Lyase Activity Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of Signaling Regulation Of Excretion
Tagcloud ?		2j allen atlas b6 bc023892 btg3 bves edinger egr1 ew ewcp ewpg ghsr housekeeping microdissection neto1 neurogenetic neuropeptides oculomotor peptidergic postn preganglionic projecting ptprn publicly punch rcn1 ucn westphal	17a 17f 1bb augment bet bipolarization car cars cd161 cd28 cd3zeta costimulator exception expand generates hematologic icos il1r nonlymphoid notable note persist persistence redirected redirection rorc th1 th17 transferred
Tagcloud (Difference) ?		2j allen atlas b6 bc023892 btg3 bves edinger egr1 ew ewcp ewpg ghsr housekeeping microdissection neto1 neurogenetic neuropeptides oculomotor peptidergic postn preganglionic projecting ptprn publicly punch rcn1 ucn westphal	17a 17f 1bb augment bet bipolarization car cars cd161 cd28 cd3zeta costimulator exception expand generates hematologic icos il1r nonlymphoid notable note persist persistence redirected redirection rorc th1 th17 transferred
Tagcloud (Intersection) ?