DRD5 and NCS1

Number of citations of the paper that reports this interaction (PubMedID 12351722)
62

Data Source:
HPRD (two hybrid)

		DRD5	NCS1
Description		dopamine receptor D5	neuronal calcium sensor 1
Image
GO Annotations	Cellular Component	Plasma Membrane Cilium Membrane Brush Border Membrane Synapse Ciliary Membrane Non-motile Cilium	Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Postsynaptic Density Membrane Axon Dendrite Synapse Perinuclear Region Of Cytoplasm
	Molecular Function	Dopamine Neurotransmitter Receptor Activity, Coupled Via Gs G Protein-coupled Receptor Activity Dopamine Neurotransmitter Receptor Activity Protein Binding Dopamine Binding	Voltage-gated Calcium Channel Activity Calcium Ion Binding Protein Binding Calcium Sensitive Guanylate Cyclase Activator Activity Metal Ion Binding
	Biological Process	Synaptic Transmission, Dopaminergic Response To Amphetamine Regulation Of Systemic Arterial Blood Pressure By Vasopressin Norepinephrine-epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Intracellular Calcium Ion Homeostasis Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway G Protein-coupled Dopamine Receptor Signaling Pathway Chemical Synaptic Transmission Mating Behavior Associative Learning Transmission Of Nerve Impulse Negative Regulation Of NAD(P)H Oxidase Activity Wound Healing Response To Cocaine Positive Regulation Of MAPK Cascade Positive Regulation Of Adenylate Cyclase Activity Negative Regulation Of Blood Pressure Regulation Of Female Receptivity Sensitization Phospholipase C-activating Dopamine Receptor Signaling Pathway Long-term Synaptic Depression Cellular Response To Catecholamine Stimulus Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Reactive Oxygen Species Metabolic Process	Regulation Of Signal Transduction Regulation Of Neuron Projection Development Calcium Ion Transmembrane Transport
Pathways		Dopamine receptors G alpha (s) signalling events
Drugs		Ziprasidone Cabergoline Cabergoline Olanzapine Olanzapine Loxapine Loxapine Imipramine Chlorpromazine Chlorpromazine Lamotrigine Cinnarizine Lisuride Ergotamine Apomorphine Paroxetine Trimipramine Fenoldopam Dopamine Dopamine Carphenazine Ergoloid mesylate Pergolide Bromocriptine Quetiapine Levodopa Aripiprazole Methotrimeprazine Zuclopenthixol Rotigotine Mianserin Nandrolone decanoate Quinagolide Zotepine Dihydro-alpha-ergocryptine Epicriptine Pipradrol Dihydroergocristine Aripiprazole lauroxil	Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases
GWAS		Gut microbiota (bacterial taxa) ( 27723756) Impulsivity (motor) ( 30718321) Lung cancer ( 28604730) Manganese levels ( 26025379) Metabolite levels ( 23823483)	Alzheimer's disease (cognitive decline) ( 23535033) Tuberculosis ( 30713548)
Interacting Genes		9 interacting genes: GABRG2 GNA12 GNA13 GNAS GNAZ KRTAP1-1 NBPF19 NCS1 NOTCH2NLA	26 interacting genes: C1QTNF2 CDSN CREM CTAG1A CTAG1B DRD2 DRD3 DRD5 DTX2 FZD7 GRK2 IL1RAPL1 KCND2 LY6G6D MEOX2 MIEF2 NBL1 OXER1 PI4KB PRDM4 RNASEH1 SFTPA2 SIGLEC9 SPP1 SPRED2 ZC3H10
Entrez ID		1816	23413
HPRD ID		00542	04500
Ensembl ID		ENSG00000169676	ENSG00000107130
Uniprot IDs		P21918	P62166
PDB IDs		8IRV	1G8I 2LCP 4GUK 5O9S 6QI4 8AHY 8ALH 8ALM
Enriched GO Terms of Interacting Partners?		Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Complex D5 Dopamine Receptor Binding Rho-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Binding G Protein Activity GTPase Activity GTP Binding Regulation Of Fibroblast Migration Brush Border Membrane G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Mu-type Opioid Receptor Binding Dendrite G Protein-coupled Serotonin Receptor Binding Regulation Of Cell Shape Hair Follicle Placode Formation Corticotropin-releasing Hormone Receptor 1 Binding Adenylate Cyclase Activator Activity Adenylate Cyclase-activating Serotonin Receptor Signaling Pathway Adenylate Cyclase Regulator Activity Adenylate Cyclase Inhibitor Activity Calcium Sensitive Guanylate Cyclase Activator Activity Cellular Response To Histamine Regulation Of Cell Communication Regulation Of Signaling Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Beta-2 Adrenergic Receptor Binding Regulation Of Blood Pressure Regulation Of Insulin Secretion D1 Dopamine Receptor Binding	Dopamine Neurotransmitter Receptor Activity Phospholipase C-activating Dopamine Receptor Signaling Pathway Synaptic Transmission, Dopaminergic G Protein-coupled Dopamine Receptor Signaling Pathway Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Regulation Of Catecholamine Secretion Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Negative Regulation Of Synaptic Transmission Dopamine Binding Response To Cocaine Negative Regulation Of Blood Pressure Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Synaptic Transmission, Glutamatergic Response To Histamine Regulation Of Dopamine Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Receptor-mediated Endocytosis Trans-synaptic Signaling Receptor Internalization Synaptic Signaling Prepulse Inhibition G Protein-coupled Receptor Internalization Regulation Of Amine Transport G Protein-coupled Receptor Activity Negative Regulation Of Cytosolic Calcium Ion Concentration Behavioral Response To Cocaine Response To Morphine Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Response To Alkaloid TRNA Threonylcarbamoyladenosine Metabolic Process Associative Learning Regulation Of Neurotransmitter Uptake Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Arachidonate Secretion Regulation Of Dopamine Secretion Rhythmic Process Acid Secretion Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Non-motile Cilium Dopamine Metabolic Process Response To Amphetamine G Protein-coupled Receptor Signaling Pathway Circadian Rhythm Negative Regulation Of Relaxation Of Smooth Muscle Negative Regulation Of The Force Of Heart Contraction By Chemical Signal Negative Regulation Of Cornification Chemical Synaptic Transmission Negative Regulation Of NAD(P)H Oxidase Activity Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury
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