DRD5 and GABRG2

Number of citations of the paper that reports this interaction (PMID 10659839)
54

Data Source:
HPRD (in vitro, in vivo)

		DRD5	GABRG2
Gene Name		dopamine receptor D5	gamma-aminobutyric acid (GABA) A receptor, gamma 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Brush Border Membrane	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell Junction Axon Dendrite Membrane Chloride Channel Complex Postsynaptic Membrane Inhibitory Synapse GABA-A Receptor Complex
	Molecular Function	Dopamine Neurotransmitter Receptor Activity, Coupled Via Gs Dopamine Neurotransmitter Receptor Activity Dopamine Binding	GABA-A Receptor Activity Extracellular Ligand-gated Ion Channel Activity Chloride Channel Activity Protein Binding Benzodiazepine Receptor Activity
	Biological Process	Synaptic Transmission, Dopaminergic Response To Amphetamine Regulation Of Systemic Arterial Blood Pressure By Vasopressin Norepinephrine-epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Cellular Calcium Ion Homeostasis Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Synaptic Transmission Associative Learning Positive Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Transmission Of Nerve Impulse Negative Regulation Of NAD(P)H Oxidase Activity Wound Healing Response To Cocaine Positive Regulation Of Adenylate Cyclase Activity Negative Regulation Of Blood Pressure Regulation Of Female Receptivity Sensitization Phospholipase C-activating Dopamine Receptor Signaling Pathway Long Term Synaptic Depression Cellular Response To Catecholamine Stimulus Reactive Oxygen Species Metabolic Process	Transport Gamma-aminobutyric Acid Signaling Pathway Synaptic Transmission Post-embryonic Development Adult Behavior Ion Transmembrane Transport Synaptic Transmission, GABAergic Transmembrane Transport Cellular Response To Histamine Chloride Transmembrane Transport
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Dopamine receptors	GABA receptor activation Ion channel transport GABA A receptor activation Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ligand-gated ion channel transport Orphan transporters Transmission across Chemical Synapses
Drugs		Ziprasidone Cabergoline Ropinirole Olanzapine Pramipexole Lisuride Apomorphine Fenoldopam Dopamine Carphenazine Pergolide Bromocriptine Quetiapine Levodopa Aripiprazole Methotrimeprazine Zuclopenthixol Rotigotine
Diseases
GWAS
Protein-Protein Interactions		5 interactors: GABRG2 GNA12 GNA13 GNAZ NCS1	6 interactors: DRD5 GABARAP PPP3CA PRKCA PRKCB ZDHHC3
Entrez ID		1816	2566
HPRD ID		00542	00663
Ensembl ID		ENSG00000169676	ENSG00000113327
Uniprot IDs		P21918	P18507
PDB IDs
Enriched GO Terms of Interacting Partners?		Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger G-protein Coupled Receptor Signaling Pathway Rho Protein Signal Transduction Intracellular Signal Transduction Regulation Of Cell Shape Signal Transduction Platelet Activation Signaling Ras Protein Signal Transduction Cell Communication Cell Surface Receptor Signaling Pathway Cellular Response To Stimulus Cellular Response To Histamine Synaptic Transmission, GABAergic Response To Histamine Blood Coagulation Hemostasis Activation Of Phospholipase D Activity Regulation Of Cell Morphogenesis Cellular Response To Ammonium Ion In Utero Embryonic Development Regulation Of Cellular Component Organization Response To Stimulus Regulation Of Body Fluid Levels Regulation Of Cell Migration Wound Healing Gamma-aminobutyric Acid Signaling Pathway Small GTPase Mediated Signal Transduction Regulation Of Cell Motility Multicellular Organismal Development Regulation Of Fibroblast Migration Regulation Of Locomotion Cell Activation Regulation Of Cellular Component Movement Response To Wounding Chordate Embryonic Development Patterning Of Blood Vessels Embryo Development Ending In Birth Or Egg Hatching Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Developmental Process Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Regulation Of TOR Signaling Positive Regulation Of Exocytosis Neuron-neuron Synaptic Transmission Embryonic Digit Morphogenesis Positive Regulation Of Phospholipase Activity	Histone H3-T6 Phosphorylation Synaptic Transmission Cell-cell Signaling Cellular Response To Carbohydrate Stimulus Cellular Chemical Homeostasis Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Glucose Transport Response To Carbohydrate Cellular Homeostasis Regulation Of Cardiac Muscle Hypertrophy Activation Of Adenylate Cyclase Activity Chemical Homeostasis Response To Amphetamine Mitotic Nuclear Envelope Disassembly Positive Regulation Of Adenylate Cyclase Activity Cellular Calcium Ion Homeostasis Negative Regulation Of Insulin Receptor Signaling Pathway Calcium Ion Homeostasis Histone Phosphorylation Nuclear Envelope Disassembly Positive Regulation Of Lyase Activity Peptidyl-threonine Phosphorylation Response To Amine Regulation Of Adenylate Cyclase Activity Negative Regulation Of Signaling Negative Regulation Of Transport Cellular Metal Ion Homeostasis Positive Regulation Of CAMP Biosynthetic Process Protein Targeting Regulation Of Insulin Receptor Signaling Pathway Regulation Of Cyclase Activity Nuclear Envelope Organization Positive Regulation Of CAMP Metabolic Process Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Homeostatic Process Protein Transport Regulation Of Cellular Response To Insulin Stimulus Positive Regulation Of Cyclic Nucleotide Metabolic Process Establishment Of Protein Localization Regulation Of CAMP Biosynthetic Process Cell Surface Receptor Signaling Pathway Ion Homeostasis Regulation Of Glucose Transport Transition Between Fast And Slow Fiber Positive Regulation Of Dense Core Granule Biogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of CAMP Metabolic Process Wound Healing
Tagcloud ?		2j allen atlas b6 bc023892 btg3 bves edinger egr1 ew ewcp ewpg ghsr housekeeping microdissection neto1 neurogenetic neuropeptides oculomotor peptidergic postn preganglionic projecting ptprn publicly punch rcn1 ucn westphal	agonistic alpha6 aminobutyric antiepileptic beta3 compromise dravet dysfunctions epilepsy gabaa gabra1 gabra6 gabrb3 gabrd gamma2 gastaut gated gating hyperpolarization infantile insufficiencies lennox myoclonic nonsense pathomechanisms pentamers seizures spasms
Tagcloud (Difference) ?		2j allen atlas b6 bc023892 btg3 bves edinger egr1 ew ewcp ewpg ghsr housekeeping microdissection neto1 neurogenetic neuropeptides oculomotor peptidergic postn preganglionic projecting ptprn publicly punch rcn1 ucn westphal	agonistic alpha6 aminobutyric antiepileptic beta3 compromise dravet dysfunctions epilepsy gabaa gabra1 gabra6 gabrb3 gabrd gamma2 gastaut gated gating hyperpolarization infantile insufficiencies lennox myoclonic nonsense pathomechanisms pentamers seizures spasms
Tagcloud (Intersection) ?