DRD1 and GRIN1

Number of citations of the paper that reports this interaction (PubMedID 12408866)
0

Data Source:
HPRD (in vitro, in vivo)

		DRD1	GRIN1
Description		dopamine receptor D1	glutamate ionotropic receptor NMDA type subunit 1
Image
GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Cilium Endomembrane System Membrane Dendrite Presynaptic Membrane Cell Projection Dendritic Spine Synapse Postsynaptic Membrane Ciliary Membrane G Protein-coupled Receptor Complex Non-motile Cilium Glutamatergic Synapse GABA-ergic Synapse	Cytoplasm Endoplasmic Reticulum Membrane Plasma Membrane Synaptic Vesicle Cell Surface Postsynaptic Density Membrane NMDA Selective Glutamate Receptor Complex Dendrite Monoatomic Ion Channel Complex Neuron Projection Synaptic Cleft Terminal Bouton Dendritic Spine Synapse Postsynaptic Membrane Excitatory Synapse Synaptic Membrane Postsynaptic Density Membrane Neurotransmitter Receptor Complex
	Molecular Function	Dopamine Neurotransmitter Receptor Activity, Coupled Via Gs G-protein Alpha-subunit Binding G Protein-coupled Receptor Activity Dopamine Neurotransmitter Receptor Activity Protein Binding Heterotrimeric G-protein Binding Dopamine Binding Arrestin Family Protein Binding	Amyloid-beta Binding NMDA Glutamate Receptor Activity Monoatomic Ion Channel Activity Calcium Channel Activity Calcium Ion Binding Protein Binding Calmodulin Binding Ligand-gated Monoatomic Ion Channel Activity Ligand-gated Sodium Channel Activity Glycine Binding Glutamate Binding Glutamate-gated Calcium Ion Channel Activity Signaling Receptor Activity Protein-containing Complex Binding Metal Ion Binding Glycine-gated Cation Channel Activity
	Biological Process	Temperature Homeostasis Conditioned Taste Aversion Behavioral Fear Response Neuron Migration Synaptic Transmission, Dopaminergic Response To Amphetamine Protein Import Into Nucleus Muscle Contraction Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway G Protein-coupled Dopamine Receptor Signaling Pathway Synapse Assembly Learning Memory Mating Behavior Grooming Behavior Locomotory Behavior Adult Walking Behavior Feeding Behavior Associative Learning Visual Learning Response To Xenobiotic Stimulus Astrocyte Development Dopamine Transport Cell Migration Transmission Of Nerve Impulse Neuronal Action Potential Dentate Gyrus Development Striatum Development Hippocampus Development Cerebral Cortex GABAergic Interneuron Migration Positive Regulation Of Cell Migration Peristalsis Operant Conditioning Synaptic Transmission, Glutamatergic Regulation Of Dopamine Metabolic Process Response To Cocaine Vasodilation Dopamine Metabolic Process Maternal Behavior Positive Regulation Of Potassium Ion Transport Positive Regulation Of MAPK Cascade D-glucose Import Habituation Sensitization Behavioral Response To Cocaine Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Synaptic Transmission, Glutamatergic Prepulse Inhibition Phospholipase C-activating Dopamine Receptor Signaling Pathway Long-term Synaptic Potentiation Long-term Synaptic Depression Cellular Response To Catecholamine Stimulus Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Modification Of Postsynaptic Structure Presynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of Neuron Migration	Monoatomic Ion Transport Monoatomic Cation Transport Chemical Synaptic Transmission Brain Development Visual Learning Positive Regulation Of Calcium Ion Transport Into Cytosol Propylene Metabolic Process Calcium-mediated Signaling Monoatomic Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Sodium Ion Transmembrane Transport Regulation Of Membrane Potential Response To Ethanol Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Synaptic Plasticity Regulation Of Neuronal Synaptic Plasticity Protein Heterotetramerization Positive Regulation Of Synaptic Transmission, Glutamatergic Calcium Ion Homeostasis Excitatory Postsynaptic Potential Calcium Ion Transmembrane Transport Calcium Ion Transmembrane Import Into Cytosol Monoatomic Cation Transmembrane Transport Excitatory Chemical Synaptic Transmission Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Monoatomic Cation Transmembrane Transport Cellular Response To Amyloid-beta Response To Glycine Positive Regulation Of Excitatory Postsynaptic Potential
Pathways		Dopamine receptors G alpha (s) signalling events	EPHB-mediated forward signaling EPHB-mediated forward signaling Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade Neurexins and neuroligins Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation
Drugs		Ziprasidone Cabergoline Cabergoline Olanzapine Olanzapine Methylergometrine Clozapine Phenylpropanolamine Loxapine Loxapine Imipramine Chlorpromazine Chlorpromazine Haloperidol Triflupromazine Amoxapine Lamotrigine Cinnarizine Lisuride Fluphenazine Thioridazine Ergotamine Apomorphine Paroxetine Trimipramine Risperidone Fenoldopam Minaprine Perphenazine Flupentixol Dopamine Dopamine Carphenazine Ergoloid mesylate Pergolide Bromocriptine Quetiapine Levodopa Aripiprazole Chlorprothixene Paliperidone Methotrimeprazine Periciazine Acepromazine Pipotiazine Thioproperazine Thiothixene Zuclopenthixol Iloperidone Rotigotine Lumateperone Mianserin Asenapine Nandrolone decanoate Quinagolide Zotepine Pipamperone Dihydro-alpha-ergocryptine Epicriptine Pipradrol Tetrahydropalmatine Dihydrexidine Dihydroergocristine Aripiprazole lauroxil	Glutamic acid Tramadol Enflurane Atomoxetine Pentobarbital Methadone Secobarbital Meperidine Dextropropoxyphene Acamprosate Donepezil Guaifenesin Memantine Memantine Orphenadrine Phenobarbital Aripiprazole Prasterone 5,7-Dichlorokynurenic acid D-Serine Cycloleucine Milnacipran CNS-5161 Acetylcysteine Ketobemidone Gavestinel Agmatine Ifenprodil Magnesium acetate tetrahydrate Magnesium carbonate Esketamine Fluciclovine (18F)
Diseases
GWAS		Cadmium levels ( 26025379) Chin dimples ( 27182965) Falling risk ( 32999390) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Treatment response for severe sepsis ( 22310353) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)	Post-traumatic stress disorder (asjusted for relatedness) ( 23726511)
Interacting Genes		19 interacting genes: ADA ADORA1 CALY CAV2 COPG1 COPG2 DLG4 DNAJC14 DRD3 EPB41L2 FLNA GHSR GRIN1 HRH3 MEIS2 PDCD6IP PRKACA TGIF1 VPS35	58 interacting genes: ACTN2 AKAP9 APP BDKRB1 CALM1 CAMK2A CAMK2G CANX CDH2 CIT CLTC CTNNB1 DLG1 DLG2 DLG3 DLG4 DLGAP4 DNM1 DRD1 DUSP4 EPHB2 EPHB4 FUS FYN GRIN2A GRIN2B GRIN2D GRIN3A HNRNPU HRAS HSPA1A INA LNX1 LRP8 MAP2 MAP2K2 MYH9 NANOS1 NEFL NF1 NR1H4 PLAT PLCG1 PPP2R1A PPP2R2A PRKCA PRKCB PRKCE PRKCG PTAFR RAP2A RPS6KA3 SP3 SPTAN1 SYNGAP1 TJP1 TRAF3 TUBA4B
Entrez ID		1812	2902
HPRD ID		00538	15926
Ensembl ID		ENSG00000184845	ENSG00000176884
Uniprot IDs		P21728	Q05586 Q59GW0 Q5VSF9
PDB IDs		7CKW 7CKX 7CKY 7CKZ 7CRH 7F0T 7F1O 7F1Z 7F23 7F24 7JOZ 7JV5 7JVP 7JVQ 7LJC 7LJD 7X2C 7X2D 7X2F 8IRR 8JXR 8JXS	2HQW 2NR1 3BYA 5H8F 5H8H 5H8N 5H8Q 5I2K 5I2N 5KCJ 5KDT 5TP9 5TPA 6IRA 6IRF 6IRG 6IRH 7EOQ 7EOR 7EOS 7EOT 7EOU 7EU7 7EU8 7YFF 7YFL 7YFM 7YFO 7YFR 8E92 8E93 8E94 8E96 8E97 8E98 8E99 8JIZ 8JJ0 8JJ1 8JJ2 8UUE 8VUL 8VUN 8VUQ 8VUR 8VUS 8VUT 8VUU 8VUV 8Y1V 9D37 9D38 9D39 9D3A 9D3B 9D3C 9GIB 9GIC 9GID 9GIE 9GIF 9GIG 9GJ1
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Dopamine Receptor Signaling Pathway Regulation Of Behavior Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway D1 Dopamine Receptor Binding Regulation Of Transport Regulation Of Dopamine Receptor Signaling Pathway Modulation Of Chemical Synaptic Transmission Secretion Cognition Negative Regulation Of Mucus Secretion Positive Regulation Of Signal Transduction Regulation Of Secretion Establishment Of Protein Localization Postsynapse Negative Regulation Of Transport Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Nervous System Process System Process Learning Or Memory Membrane Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Vesicle-mediated Transport Regulation Of Locomotion Involved In Locomotory Behavior Positive Regulation Of Transport Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Biological Quality Regulation Of System Process Glutamatergic Synapse Heterotrimeric G-protein Binding Regulation Of Secretion By Cell Learning Nervous System Process Visual Learning Regulation Of Metal Ion Transport Regulation Of Mucus Secretion Negative Regulation Of Secretion Regulation Of Muscle Contraction Receptor-mediated Endocytosis Negative Regulation Of Inflammatory Response Negative Regulation Of Synaptic Transmission, Glutamatergic Visual Behavior Synaptic Membrane Cell Communication Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Receptor Internalization	Modulation Of Chemical Synaptic Transmission Glutamatergic Synapse Regulation Of Neuronal Synaptic Plasticity Regulation Of Biological Quality Regulation Of Synaptic Plasticity Trans-synaptic Signaling Synaptic Signaling Positive Regulation Of Synaptic Transmission Chemical Synaptic Transmission Regulation Of Cellular Component Organization Long-term Synaptic Potentiation Neuron Projection Synapse Signaling Postsynaptic Density Membrane Cell Communication Regulation Of Monoatomic Ion Transport Regulation Of Cell Communication Regulation Of Signaling Cell-cell Signaling Regulation Of Transport Synaptic Membrane Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Anatomical Structure Morphogenesis Regulation Of Synapse Organization Glutamate Receptor Signaling Pathway Ionotropic Glutamate Receptor Signaling Pathway Signal Transduction Plasma Membrane Postsynaptic Density Regulation Of Metal Ion Transport Regulation Of Cellular Localization Learning Or Memory Cell Projection Protein Kinase Binding Regulation Of Apoptotic Process Cell Junction Organization NMDA Glutamate Receptor Activity Regulation Of Calcium Ion Transport Dendrite Ligand-gated Ion Channel Signaling Pathway Regulation Of Protein Localization Developmental Process Regulation Of Protein Localization To Membrane Regulation Of Programmed Cell Death Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cognition
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