DRD1 and EPB41L2

Number of citations of the paper that reports this interaction (PMID 12181426)
22

Data Source:
HPRD (two hybrid)

		DRD1	EPB41L2
Gene Name		dopamine receptor D1	erythrocyte membrane protein band 4.1-like 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane	Nucleus Nucleoplasm Plasma Membrane Focal Adhesion Spectrin COP9 Signalosome Extrinsic Component Of Membrane Cell Junction Extracellular Vesicular Exosome
	Molecular Function	Dopamine Neurotransmitter Receptor Activity, Coupled Via Gs Dopamine Neurotransmitter Receptor Activity Protein Binding Dopamine Binding	Actin Binding Structural Molecule Activity PH Domain Binding
	Biological Process	Temperature Homeostasis Conditioned Taste Aversion Behavioral Fear Response Synaptic Transmission, Dopaminergic Response To Amphetamine Protein Import Into Nucleus G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Synapse Assembly Memory Mating Behavior Grooming Behavior Adult Walking Behavior Visual Learning Positive Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Astrocyte Development Dopamine Transport Transmission Of Nerve Impulse Neuronal Action Potential Dentate Gyrus Development Striatum Development Cerebral Cortex GABAergic Interneuron Migration Positive Regulation Of Cell Migration Peristalsis Positive Regulation Of CAMP Biosynthetic Process Operant Conditioning Regulation Of Dopamine Metabolic Process Vasodilation Dopamine Metabolic Process Response To Drug Maternal Behavior Positive Regulation Of Potassium Ion Transport Glucose Import Habituation Sensitization Behavioral Response To Cocaine Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Regulation Of Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Synaptic Transmission, Glutamatergic Prepulse Inhibition Phospholipase C-activating Dopamine Receptor Signaling Pathway Long-term Synaptic Potentiation Long Term Synaptic Depression Cellular Response To Catecholamine Stimulus	Cortical Actin Cytoskeleton Organization
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Dopamine receptors
Drugs		Ziprasidone Cabergoline Ropinirole Olanzapine Methylergonovine Clozapine Thiethylperazine Phenylpropanolamine Loxapine Pramipexole Promazine Chlorpromazine Haloperidol Triflupromazine Amoxapine Lisuride Fluphenazine Thioridazine Apomorphine Trimipramine Risperidone Propiomazine Fenoldopam Minaprine Perphenazine Flupenthixol Dopamine Carphenazine Acetophenazine Pergolide Bromocriptine Quetiapine Levodopa Aripiprazole Chlorprothixene Paliperidone Dihydroergotoxine Methotrimeprazine Propericiazine Acepromazine Pipotiazine Thioproperazine Thiothixene Zuclopenthixol Iloperidone Rotigotine Asenapine
Diseases
GWAS		Obesity-related traits ( 23251661) Treatment response for severe sepsis ( 22310353)	Lentiform nucleus volume ( 22903471) Response to statin therapy (LDL-C) ( 22331829)
Protein-Protein Interactions		11 interactors: ADA ADORA1 CALY CAV2 COPG1 COPG2 DNAJC14 EPB41L2 FLNA GRIN1 HRH3	13 interactors: ACTA1 ADORA1 APP ATXN1L DRD1 DRD3 FKBP2 GRIA1 NUMA1 SPTAN1 YWHAG YWHAH YWHAZ
Entrez ID		1812	2037
HPRD ID		00538	09126
Ensembl ID		ENSG00000184845	ENSG00000079819
Uniprot IDs		P21728	B4DJ76 E9PHY5 E9PII3 I6L9B1 O43491 O60642 Q59FD8
PDB IDs		1OZ5
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Mucus Secretion Negative Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Transport Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of Glutamate Secretion Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Regulation Of Glutamate Secretion Vesicle-mediated Transport Negative Regulation Of Transport Membrane Organization Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Mucus Secretion G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Negative Regulation Of Circadian Rhythm Negative Regulation Of Leukocyte Migration Regulation Of Respiratory Gaseous Exchange Negative Regulation Of Secretion Vesicle Organization Dopamine Receptor Signaling Pathway Retrograde Vesicle-mediated Transport, Golgi To ER Response To Morphine Negative Regulation Of Blood Pressure Regulation Of Smooth Muscle Contraction Cognition Establishment Of Protein Localization Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Long Term Synaptic Depression Negative Regulation Of Neurotrophin Production Deoxyadenosine Catabolic Process Positive Regulation Of Nucleoside Transport Negative Regulation Of Adenosine Receptor Signaling Pathway Negative Regulation Of Penile Erection Propylene Metabolic Process Xanthine Biosynthetic Process Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Membrane Budding Sensory Perception Of Pain Response To Ammonium Ion Protein Complex Assembly Negative Regulation Of Ion Transport Regulation Of Circadian Rhythm Feeding Behavior Olfactory Learning Negative Regulation Of Gamma-aminobutyric Acid Secretion Purine Deoxyribonucleoside Metabolic Process Protein Localization Negative Regulation Of Inflammatory Response Establishment Of Localization In Cell	Regulation Of Synaptic Transmission Regulation Of Synaptic Plasticity Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Cognition Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Transport Positive Regulation Of Mitochondrion Organization System Development Visual Learning Negative Regulation Of Synaptic Transmission Visual Behavior Neuron-neuron Synaptic Transmission Apoptotic Process Positive Regulation Of Intracellular Transport Programmed Cell Death Regulation Of Cellular Localization Cell Death Death Learning Or Memory Regulation Of Dopamine Uptake Involved In Synaptic Transmission Associative Learning Multicellular Organismal Development Regulation Of Mitochondrion Organization Anatomical Structure Development Synaptic Transmission, Dopaminergic Behavioral Response To Cocaine Apoptotic Signaling Pathway Regulation Of Neurotransmitter Uptake Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Establishment Of Localization In Cell Prepulse Inhibition Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Circadian Sleep/wake Cycle, Sleep Long Term Synaptic Depression Regulation Of Synaptic Transmission, Dopaminergic Neuromuscular Process Positive Regulation Of Organelle Organization Learning Regulation Of Signaling Regulation Of Anion Transport Protein Targeting Developmental Process Regulation Of Renal Sodium Excretion G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Intracellular Transport Nervous System Development Intracellular Transport Cell-cell Signaling Regulation Of Excretion
Tagcloud ?		adrenocorticotropic appetite blair denton embodied experimentation fitzsimons gluco gratification gratified instinct instinctive instincts intricately johnson lehrman liedtke luca mineralocorticoids respected richter roitman satiation sentiment suprarenal thirst thunhorst veteran wolf
Tagcloud (Difference) ?		adrenocorticotropic appetite blair denton embodied experimentation fitzsimons gluco gratification gratified instinct instinctive instincts intricately johnson lehrman liedtke luca mineralocorticoids respected richter roitman satiation sentiment suprarenal thirst thunhorst veteran wolf
Tagcloud (Intersection) ?