DRD1 and EPB41L2

Number of citations of the paper that reports this interaction (PubMedID 12181426)
0

Data Source:
HPRD (two hybrid)

		DRD1	EPB41L2
Description		dopamine receptor D1	erythrocyte membrane protein band 4.1 like 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Cilium Endomembrane System Membrane Dendrite Presynaptic Membrane Cell Projection Dendritic Spine Synapse Postsynaptic Membrane Ciliary Membrane G Protein-coupled Receptor Complex Non-motile Cilium Glutamatergic Synapse GABA-ergic Synapse	Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Cell Cortex Spectrin COP9 Signalosome Membrane Cell Junction Extracellular Exosome
	Molecular Function	Dopamine Neurotransmitter Receptor Activity, Coupled Via Gs G-protein Alpha-subunit Binding G Protein-coupled Receptor Activity Dopamine Neurotransmitter Receptor Activity Protein Binding Heterotrimeric G-protein Binding Dopamine Binding Arrestin Family Protein Binding	Actin Binding Structural Molecule Activity Protein Binding Cytoskeletal Protein Binding Spectrin Binding PH Domain Binding
	Biological Process	Temperature Homeostasis Conditioned Taste Aversion Behavioral Fear Response Neuron Migration Synaptic Transmission, Dopaminergic Response To Amphetamine Protein Import Into Nucleus Muscle Contraction Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway G Protein-coupled Dopamine Receptor Signaling Pathway Synapse Assembly Learning Memory Mating Behavior Grooming Behavior Locomotory Behavior Adult Walking Behavior Feeding Behavior Associative Learning Visual Learning Response To Xenobiotic Stimulus Astrocyte Development Dopamine Transport Cell Migration Transmission Of Nerve Impulse Neuronal Action Potential Dentate Gyrus Development Striatum Development Hippocampus Development Cerebral Cortex GABAergic Interneuron Migration Positive Regulation Of Cell Migration Peristalsis Operant Conditioning Synaptic Transmission, Glutamatergic Regulation Of Dopamine Metabolic Process Response To Cocaine Vasodilation Dopamine Metabolic Process Maternal Behavior Positive Regulation Of Potassium Ion Transport Positive Regulation Of MAPK Cascade D-glucose Import Habituation Sensitization Behavioral Response To Cocaine Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Synaptic Transmission, Glutamatergic Prepulse Inhibition Phospholipase C-activating Dopamine Receptor Signaling Pathway Long-term Synaptic Potentiation Long-term Synaptic Depression Cellular Response To Catecholamine Stimulus Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Modification Of Postsynaptic Structure Presynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of Neuron Migration	Cortical Actin Cytoskeleton Organization Actomyosin Structure Organization Cell Division Positive Regulation Of Protein Localization To Cell Cortex
Pathways		Dopamine receptors G alpha (s) signalling events	Neurexins and neuroligins
Drugs		Ziprasidone Cabergoline Cabergoline Olanzapine Olanzapine Methylergometrine Clozapine Phenylpropanolamine Loxapine Loxapine Imipramine Chlorpromazine Chlorpromazine Haloperidol Triflupromazine Amoxapine Lamotrigine Cinnarizine Lisuride Fluphenazine Thioridazine Ergotamine Apomorphine Paroxetine Trimipramine Risperidone Fenoldopam Minaprine Perphenazine Flupentixol Dopamine Dopamine Carphenazine Ergoloid mesylate Pergolide Bromocriptine Quetiapine Levodopa Aripiprazole Chlorprothixene Paliperidone Methotrimeprazine Periciazine Acepromazine Pipotiazine Thioproperazine Thiothixene Zuclopenthixol Iloperidone Rotigotine Lumateperone Mianserin Asenapine Nandrolone decanoate Quinagolide Zotepine Pipamperone Dihydro-alpha-ergocryptine Epicriptine Pipradrol Tetrahydropalmatine Dihydrexidine Dihydroergocristine Aripiprazole lauroxil
Diseases
GWAS		Cadmium levels ( 26025379) Chin dimples ( 27182965) Falling risk ( 32999390) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Treatment response for severe sepsis ( 22310353) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)	Appendicular lean mass ( 33097823) Cerebellum white matter volume ( 31530798) Colorectal cancer (calcium intake interaction) ( 25192705) Creativity ( 32133506) Heel bone mineral density ( 28869591 30598549) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Lentiform nucleus volume ( 22903471) Loneliness ( 31518406 29970889) Loneliness (MTAG) ( 29970889) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Pars triangularis volume ( 31530798) Plateletcrit ( 32888494) Response to statins (LDL cholesterol change) ( 22331829) Systolic blood pressure ( 30224653) Urolithiasis ( 30975718)
Interacting Genes		19 interacting genes: ADA ADORA1 CALY CAV2 COPG1 COPG2 DLG4 DNAJC14 DRD3 EPB41L2 FLNA GHSR GRIN1 HRH3 MEIS2 PDCD6IP PRKACA TGIF1 VPS35	17 interacting genes: ACTA1 ADORA1 APP ATXN1L DRD1 DRD3 FKBP2 GRIA1 GRM1 HMGA1 HSPB1 NUMA1 PARP1 RNF10 SPTAN1 VIM YWHAH
Entrez ID		1812	2037
HPRD ID		00538	09126
Ensembl ID		ENSG00000184845	ENSG00000079819
Uniprot IDs		P21728	A0A994J5B1 B4DJ76 E9PHY5 E9PII3 I6L9B1 O43491 Q59FD8
PDB IDs		7CKW 7CKX 7CKY 7CKZ 7CRH 7F0T 7F1O 7F1Z 7F23 7F24 7JOZ 7JV5 7JVP 7JVQ 7LJC 7LJD 7X2C 7X2D 7X2F 8IRR 8JXR 8JXS
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Dopamine Receptor Signaling Pathway Regulation Of Behavior Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway D1 Dopamine Receptor Binding Regulation Of Transport Regulation Of Dopamine Receptor Signaling Pathway Modulation Of Chemical Synaptic Transmission Secretion Cognition Negative Regulation Of Mucus Secretion Positive Regulation Of Signal Transduction Regulation Of Secretion Establishment Of Protein Localization Postsynapse Negative Regulation Of Transport Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Nervous System Process System Process Learning Or Memory Membrane Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Vesicle-mediated Transport Regulation Of Locomotion Involved In Locomotory Behavior Positive Regulation Of Transport Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Biological Quality Regulation Of System Process Glutamatergic Synapse Heterotrimeric G-protein Binding Regulation Of Secretion By Cell Learning Nervous System Process Visual Learning Regulation Of Metal Ion Transport Regulation Of Mucus Secretion Negative Regulation Of Secretion Regulation Of Muscle Contraction Receptor-mediated Endocytosis Negative Regulation Of Inflammatory Response Negative Regulation Of Synaptic Transmission, Glutamatergic Visual Behavior Synaptic Membrane Cell Communication Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Receptor Internalization	Regulation Of Nervous System Process Regulation Of Membrane Potential Negative Regulation Of Synaptic Transmission Dendrite Modulation Of Chemical Synaptic Transmission Cognition Learning Long-term Synaptic Depression Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Neurotransmitter Uptake Cell Body Regulation Of Synaptic Plasticity Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Monoatomic Ion Transport Associative Learning Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Learning Or Memory Memory Positive Regulation Of Synaptic Transmission Regulation Of System Process Nervous System Process Response To Nerve Growth Factor Cellular Response To Nerve Growth Factor Stimulus Chemical Synaptic Transmission Response To Cocaine Dopamine Neurotransmitter Receptor Activity Dendritic Spine Cell-cell Signaling Synapse Regulation Of Metal Ion Transport Glutamate Receptor Signaling Pathway Trans-synaptic Signaling Synaptic Signaling Heterotrimeric G-protein Binding Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Visual Learning Signaling Regulation Of Dopamine Uptake Involved In Synaptic Transmission Phospholipase C-activating Dopamine Receptor Signaling Pathway Cell Communication Visual Behavior System Process Negative Regulation Of Synaptic Transmission, Glutamatergic Locomotory Behavior Glial Cell Development Regulation Of Biological Quality Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Regulation Of Behavior Negative Regulation Of Long-term Synaptic Potentiation Regulation Of Amine Transport
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