DRD1 and CAV2

Number of citations of the paper that reports this interaction (PubMedID 15569306)
0

Data Source:
HPRD (in vitro)

		DRD1	CAV2
Description		dopamine receptor D1	caveolin 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Cilium Endomembrane System Membrane Dendrite Presynaptic Membrane Cell Projection Dendritic Spine Synapse Postsynaptic Membrane Ciliary Membrane G Protein-coupled Receptor Complex Non-motile Cilium Glutamatergic Synapse GABA-ergic Synapse	Golgi Membrane Acrosomal Membrane Caveolar Macromolecular Signaling Complex Nucleus Cytoplasm Golgi Apparatus Plasma Membrane Caveola Focal Adhesion Membrane Transport Vesicle Cytoplasmic Vesicle Protein-containing Complex Plasma Membrane Raft Membrane Raft Perinuclear Region Of Cytoplasm
	Molecular Function	Dopamine Neurotransmitter Receptor Activity, Coupled Via Gs G-protein Alpha-subunit Binding G Protein-coupled Receptor Activity Dopamine Neurotransmitter Receptor Activity Protein Binding Heterotrimeric G-protein Binding Dopamine Binding Arrestin Family Protein Binding	Protein Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity D1 Dopamine Receptor Binding Heterotrimeric G-protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Molecular Adaptor Activity Scaffold Protein Binding
	Biological Process	Temperature Homeostasis Conditioned Taste Aversion Behavioral Fear Response Neuron Migration Synaptic Transmission, Dopaminergic Response To Amphetamine Protein Import Into Nucleus Muscle Contraction Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway G Protein-coupled Dopamine Receptor Signaling Pathway Synapse Assembly Learning Memory Mating Behavior Grooming Behavior Locomotory Behavior Adult Walking Behavior Feeding Behavior Associative Learning Visual Learning Response To Xenobiotic Stimulus Astrocyte Development Dopamine Transport Cell Migration Transmission Of Nerve Impulse Neuronal Action Potential Dentate Gyrus Development Striatum Development Hippocampus Development Cerebral Cortex GABAergic Interneuron Migration Positive Regulation Of Cell Migration Peristalsis Operant Conditioning Synaptic Transmission, Glutamatergic Regulation Of Dopamine Metabolic Process Response To Cocaine Vasodilation Dopamine Metabolic Process Maternal Behavior Positive Regulation Of Potassium Ion Transport Positive Regulation Of MAPK Cascade D-glucose Import Habituation Sensitization Behavioral Response To Cocaine Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Synaptic Transmission, Glutamatergic Prepulse Inhibition Phospholipase C-activating Dopamine Receptor Signaling Pathway Long-term Synaptic Potentiation Long-term Synaptic Depression Cellular Response To Catecholamine Stimulus Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Modification Of Postsynaptic Structure Presynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of Neuron Migration	Endothelial Cell Proliferation Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Vesicle Fusion Mitochondrion Organization Endoplasmic Reticulum Organization Regulation Of Mitotic Nuclear Division Transforming Growth Factor Beta Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Cell Population Proliferation Insulin Receptor Signaling Pathway Skeletal Muscle Cell Proliferation Negative Regulation Of Skeletal Muscle Cell Proliferation Vesicle Organization Receptor-mediated Endocytosis Of Virus By Host Cell Viral Release From Host Cell Cell Differentiation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Host-mediated Activation Of Viral Process Vesicle Docking Skeletal Muscle Fiber Development Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Dopamine Receptor Signaling Pathway Caveola Assembly Basement Membrane Organization
Pathways		Dopamine receptors G alpha (s) signalling events	Extra-nuclear estrogen signaling
Drugs		Ziprasidone Cabergoline Cabergoline Olanzapine Olanzapine Methylergometrine Clozapine Phenylpropanolamine Loxapine Loxapine Imipramine Chlorpromazine Chlorpromazine Haloperidol Triflupromazine Amoxapine Lamotrigine Cinnarizine Lisuride Fluphenazine Thioridazine Ergotamine Apomorphine Paroxetine Trimipramine Risperidone Fenoldopam Minaprine Perphenazine Flupentixol Dopamine Dopamine Carphenazine Ergoloid mesylate Pergolide Bromocriptine Quetiapine Levodopa Aripiprazole Chlorprothixene Paliperidone Methotrimeprazine Periciazine Acepromazine Pipotiazine Thioproperazine Thiothixene Zuclopenthixol Iloperidone Rotigotine Lumateperone Mianserin Asenapine Nandrolone decanoate Quinagolide Zotepine Pipamperone Dihydro-alpha-ergocryptine Epicriptine Pipradrol Tetrahydropalmatine Dihydrexidine Dihydroergocristine Aripiprazole lauroxil
Diseases
GWAS		Cadmium levels ( 26025379) Chin dimples ( 27182965) Falling risk ( 32999390) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Treatment response for severe sepsis ( 22310353) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)	Antipsychotic drug-induced weight gain in schizophrenia ( 31447353) Atrial fibrillation ( 33990960 30061737 29892015) Glaucoma ( 31959993 30054594) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 20835238 33627673 29891935 25173105) Heart rate increase in response to exercise ( 29497042) Heart rate response to exercise ( 29769521) Heart rate response to recovery post exercise ( 29769521) Heart rate response to recovery post exercise (10 sec) ( 29497042) Heart rate response to recovery post exercise (20 sec) ( 29497042) Heart rate response to recovery post exercise (30 sec) ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) Intraocular pressure ( 30054594 31959993 25173106 31798171 28073927 29785010 29617998) P wave duration ( 28794112) Pancreatic ductal adenocarcinoma ( 33975060) PR interval ( 29127183 30046033 32439900 25035420 20062060) Refractive error ( 32231278) TPE interval (resting) ( 32386560)
Interacting Genes		19 interacting genes: ADA ADORA1 CALY CAV2 COPG1 COPG2 DLG4 DNAJC14 DRD3 EPB41L2 FLNA GHSR GRIN1 HRH3 MEIS2 PDCD6IP PRKACA TGIF1 VPS35	13 interacting genes: CAV1 CSNK2A1 DNAJA1 DRD1 EGFR FLOT2 GOLGB1 MALL NCK1 RASA1 SDCBP SNCA SRC
Entrez ID		1812	858
HPRD ID		00538	03029
Ensembl ID		ENSG00000184845	ENSG00000105971
Uniprot IDs		P21728	P51636 Q53X57
PDB IDs		7CKW 7CKX 7CKY 7CKZ 7CRH 7F0T 7F1O 7F1Z 7F23 7F24 7JOZ 7JV5 7JVP 7JVQ 7LJC 7LJD 7X2C 7X2D 7X2F 8IRR 8JXR 8JXS
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Dopamine Receptor Signaling Pathway Regulation Of Behavior Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway D1 Dopamine Receptor Binding Regulation Of Transport Regulation Of Dopamine Receptor Signaling Pathway Modulation Of Chemical Synaptic Transmission Secretion Cognition Negative Regulation Of Mucus Secretion Positive Regulation Of Signal Transduction Regulation Of Secretion Establishment Of Protein Localization Postsynapse Negative Regulation Of Transport Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Nervous System Process System Process Learning Or Memory Membrane Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Vesicle-mediated Transport Regulation Of Locomotion Involved In Locomotory Behavior Positive Regulation Of Transport Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Biological Quality Regulation Of System Process Glutamatergic Synapse Heterotrimeric G-protein Binding Regulation Of Secretion By Cell Learning Nervous System Process Visual Learning Regulation Of Metal Ion Transport Regulation Of Mucus Secretion Negative Regulation Of Secretion Regulation Of Muscle Contraction Receptor-mediated Endocytosis Negative Regulation Of Inflammatory Response Negative Regulation Of Synaptic Transmission, Glutamatergic Visual Behavior Synaptic Membrane Cell Communication Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Receptor Internalization	Membrane Raft Protein Sequestering Activity Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Regulation Of Primary Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Macromolecule Metabolic Process Regulation Of Apoptotic Process Negative Regulation Of Protein Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Metabolic Process Protein Localization To Plasma Membrane Raft Negative Regulation Of Signaling Regulation Of Programmed Cell Death Negative Regulation Of Cell Communication Regulation Of Protein Metabolic Process Regulation Of Locomotion Perinuclear Region Of Cytoplasm Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Apoptotic Signaling Pathway Ephrin Receptor Signaling Pathway Enzyme Binding Positive Regulation Of Intracellular Signal Transduction Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Calcium Ion Transmembrane Transport Focal Adhesion Regulation Of Dopamine Uptake Involved In Synaptic Transmission Signal Complex Assembly Protein Localization To Membrane Raft Positive Regulation Of MAPK Cascade Caveola Substrate-dependent Cell Migration, Cell Extension Positive Regulation Of Cellular Component Biogenesis ATPase Binding Regulation Of RNA Metabolic Process Regulation Of Cellular Response To Stress Positive Regulation Of T Cell Activation Regulation Of Macromolecule Metabolic Process Negative Regulation Of Signal Transduction Positive Regulation Of Cell Migration Plasma Membrane Regulation Of Cell Migration Negative Regulation Of Transcription By RNA Polymerase II Cellular Response To Growth Factor Stimulus
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