DRD1 and CAV2

Number of citations of the paper that reports this interaction (PMID 15569306)
28

Data Source:
HPRD (in vitro)

		DRD1	CAV2
Gene Name		dopamine receptor D1	caveolin 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane	Golgi Membrane Acrosomal Membrane Intracellular Nucleus Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Caveola Focal Adhesion Membrane Transport Vesicle Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cytoplasmic Vesicle Protein Complex Membrane Raft Perinuclear Region Of Cytoplasm
	Molecular Function	Dopamine Neurotransmitter Receptor Activity, Coupled Via Gs Dopamine Neurotransmitter Receptor Activity Protein Binding Dopamine Binding	Protein Binding D1 Dopamine Receptor Binding Protein Homodimerization Activity
	Biological Process	Temperature Homeostasis Conditioned Taste Aversion Behavioral Fear Response Synaptic Transmission, Dopaminergic Response To Amphetamine Protein Import Into Nucleus G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Synapse Assembly Memory Mating Behavior Grooming Behavior Adult Walking Behavior Visual Learning Positive Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Astrocyte Development Dopamine Transport Transmission Of Nerve Impulse Neuronal Action Potential Dentate Gyrus Development Striatum Development Cerebral Cortex GABAergic Interneuron Migration Positive Regulation Of Cell Migration Peristalsis Positive Regulation Of CAMP Biosynthetic Process Operant Conditioning Regulation Of Dopamine Metabolic Process Vasodilation Dopamine Metabolic Process Response To Drug Maternal Behavior Positive Regulation Of Potassium Ion Transport Glucose Import Habituation Sensitization Behavioral Response To Cocaine Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Regulation Of Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Synaptic Transmission, Glutamatergic Prepulse Inhibition Phospholipase C-activating Dopamine Receptor Signaling Pathway Long-term Synaptic Potentiation Long Term Synaptic Depression Cellular Response To Catecholamine Stimulus	Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Vesicle Fusion Mitochondrion Organization Endoplasmic Reticulum Organization Regulation Of Mitotic Nuclear Division Insulin Receptor Signaling Pathway Vesicle Organization Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of GTPase Activity Vesicle Docking Skeletal Muscle Fiber Development Protein Oligomerization Positive Regulation Of Dopamine Receptor Signaling Pathway Caveola Assembly
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Dopamine receptors
Drugs		Ziprasidone Cabergoline Ropinirole Olanzapine Methylergonovine Clozapine Thiethylperazine Phenylpropanolamine Loxapine Pramipexole Promazine Chlorpromazine Haloperidol Triflupromazine Amoxapine Lisuride Fluphenazine Thioridazine Apomorphine Trimipramine Risperidone Propiomazine Fenoldopam Minaprine Perphenazine Flupenthixol Dopamine Carphenazine Acetophenazine Pergolide Bromocriptine Quetiapine Levodopa Aripiprazole Chlorprothixene Paliperidone Dihydroergotoxine Methotrimeprazine Propericiazine Acepromazine Pipotiazine Thioproperazine Thiothixene Zuclopenthixol Iloperidone Rotigotine Asenapine
Diseases
GWAS		Obesity-related traits ( 23251661) Treatment response for severe sepsis ( 22310353)	Glaucoma (primary open-angle) ( 20835238) PR interval ( 20062060)
Protein-Protein Interactions		11 interactors: ADA ADORA1 CALY CAV2 COPG1 COPG2 DNAJC14 EPB41L2 FLNA GRIN1 HRH3	11 interactors: CAV1 CSNK2A1 DNAJA1 DRD1 EGFR FLOT2 GOLGB1 MALL NCK1 RASA1 SRC
Entrez ID		1812	858
HPRD ID		00538	03029
Ensembl ID		ENSG00000184845	ENSG00000105971
Uniprot IDs		P21728	P51636 Q53X57
PDB IDs		1OZ5
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Mucus Secretion Negative Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Transport Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of Glutamate Secretion Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Regulation Of Glutamate Secretion Vesicle-mediated Transport Negative Regulation Of Transport Membrane Organization Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Mucus Secretion G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Negative Regulation Of Circadian Rhythm Negative Regulation Of Leukocyte Migration Regulation Of Respiratory Gaseous Exchange Negative Regulation Of Secretion Vesicle Organization Dopamine Receptor Signaling Pathway Retrograde Vesicle-mediated Transport, Golgi To ER Response To Morphine Negative Regulation Of Blood Pressure Regulation Of Smooth Muscle Contraction Cognition Establishment Of Protein Localization Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Long Term Synaptic Depression Negative Regulation Of Neurotrophin Production Deoxyadenosine Catabolic Process Positive Regulation Of Nucleoside Transport Negative Regulation Of Adenosine Receptor Signaling Pathway Negative Regulation Of Penile Erection Propylene Metabolic Process Xanthine Biosynthetic Process Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Membrane Budding Sensory Perception Of Pain Response To Ammonium Ion Protein Complex Assembly Negative Regulation Of Ion Transport Regulation Of Circadian Rhythm Feeding Behavior Olfactory Learning Negative Regulation Of Gamma-aminobutyric Acid Secretion Purine Deoxyribonucleoside Metabolic Process Protein Localization Negative Regulation Of Inflammatory Response Establishment Of Localization In Cell	Locomotion Negative Regulation Of Protein Metabolic Process Movement Of Cell Or Subcellular Component Negative Regulation Of Cell Death Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Signaling Axon Guidance Regulation Of Apoptotic Process Cell Motility Negative Regulation Of Apoptotic Process Regulation Of Catalytic Activity Regulation Of Cell Death Negative Regulation Of Programmed Cell Death Neuron Development Axonogenesis Axon Development Negative Regulation Of Signal Transduction Cell Morphogenesis Involved In Neuron Differentiation Response To External Stimulus Chemotaxis Neuron Differentiation Neuron Projection Morphogenesis Regulation Of MAP Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Signaling Cell Morphogenesis Involved In Differentiation Regulation Of Protein Kinase Activity Regulation Of Protein Metabolic Process Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Negative Regulation Of Cellular Protein Metabolic Process Neuron Projection Development Negative Regulation Of Anoikis Signal Complex Assembly Regulation Of Phosphorus Metabolic Process Cell Migration Cell Projection Morphogenesis Cell Part Morphogenesis Negative Regulation Of Intracellular Signal Transduction Generation Of Neurons Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Anoikis Regulation Of Intracellular Transport Neurogenesis Astrocyte Development Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Intrinsic Apoptotic Signaling Pathway Gland Morphogenesis
Tagcloud ?		adrenocorticotropic appetite blair denton embodied experimentation fitzsimons gluco gratification gratified instinct instinctive instincts intricately johnson lehrman liedtke luca mineralocorticoids respected richter roitman satiation sentiment suprarenal thirst thunhorst veteran wolf	3tau alpha1 alpha1b alpha2delta altogether auxiliary ba2 cavbeta channels clamp closer coexpression construct excitable facilitated gated mysterious physiology pore pscm138 pscm174 recording retained traffic trafficked tsa unidentified voltage
Tagcloud (Difference) ?		adrenocorticotropic appetite blair denton embodied experimentation fitzsimons gluco gratification gratified instinct instinctive instincts intricately johnson lehrman liedtke luca mineralocorticoids respected richter roitman satiation sentiment suprarenal thirst thunhorst veteran wolf	3tau alpha1 alpha1b alpha2delta altogether auxiliary ba2 cavbeta channels clamp closer coexpression construct excitable facilitated gated mysterious physiology pore pscm138 pscm174 recording retained traffic trafficked tsa unidentified voltage
Tagcloud (Intersection) ?