DOCK2 and CD247

Number of citations of the paper that reports this interaction (PMID 12176041)
5

Data Source:
HPRD (in vivo)

		DOCK2	CD247
Gene Name		dedicator of cytokinesis 2	CD247 molecule
Image
Gene Ontology Annotations	Cellular Component	Cytosol Cytoskeleton Endomembrane System Membrane Extracellular Vesicular Exosome	Cytoplasm Plasma Membrane Integral Component Of Membrane T Cell Receptor Complex Alpha-beta T Cell Receptor Complex
	Molecular Function	Protein Binding Rac GTPase Activator Activity Rac Guanyl-nucleotide Exchange Factor Activity T Cell Receptor Binding	Transmembrane Signaling Receptor Activity Protein Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Membrane Raft Polarization Establishment Of T Cell Polarity Immunological Synapse Formation Myeloid Dendritic Cell Activation Involved In Immune Response Chemotaxis Small GTPase Mediated Signal Transduction Viral Process Actin Cytoskeleton Organization Positive Regulation Of Rac GTPase Activity Macropinocytosis Positive Thymic T Cell Selection Negative Thymic T Cell Selection Alpha-beta T Cell Proliferation Regulation Of Defense Response To Virus By Virus Positive Regulation Of Phagocytosis	Viral Process T Cell Costimulation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Regulation Of Defense Response To Virus By Virus Regulation Of Immune Response T Cell Receptor Signaling Pathway
Pathways		HIV Infection Host Interactions of HIV factors The role of Nef in HIV-1 replication and disease pathogenesis Factors involved in megakaryocyte development and platelet production Nef and signal transduction
Drugs
Diseases
GWAS		Protein quantitative trait loci ( 18464913)	Celiac disease ( 20190752) Celiac disease and Rheumatoid arthritis ( 21383967) Rheumatoid arthritis ( 20453842) Systemic sclerosis ( 21750679 20383147 21779181)
Protein-Protein Interactions		25 interactors: CALCOCO2 CCNDBP1 CD247 CRKL HNRNPK KHDRBS1 KHDRBS2 KRT40 KRTAP10-1 KRTAP10-3 KRTAP10-8 KRTAP10-9 KRTAP4-2 KRTAP5-9 KRTAP9-2 KRTAP9-4 MDFI MTUS2 NOTCH2NL PAK2 PLSCR1 RAC1 RAC2 TRIM23 VAV1	38 interactors: CD2 CD244 CD28 CD3D CD48 CD5 CSK DOCK2 FCGR3A FYN GAB2 GRB2 JAK3 LCK LY6E NCR1 NCR3 PCGF2 PI4K2B PTPN22 PTPN3 PTPN6 PTPRC SH2B3 SHC1 SLA SLA2 STAT5A STAT5B TFRC TIRAP TRA TRAT1 TRB UNC119 VTN ZAP70 ZNF281
Entrez ID		1794	919
HPRD ID		09121	01729
Ensembl ID		ENSG00000134516	ENSG00000198821
Uniprot IDs		Q5XG91 Q92608	P20963
PDB IDs		2RQR 2YIN 3A98 3B13	1TCE 1YGR 2HAC 2OQ1 3IK5 3IOZ
Enriched GO Terms of Interacting Partners?		T Cell Costimulation Regulation Of Defense Response To Virus By Virus Viral Process Platelet Activation Positive Regulation Of T Cell Activation Regulation Of Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Immune System Process Positive Regulation Of Cell-cell Adhesion Regulation Of Hydrogen Peroxide Metabolic Process Regulation Of Defense Response To Virus Fc Receptor Signaling Pathway Regulation Of Respiratory Burst Positive Regulation Of Catalytic Activity Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Lamellipodium Assembly Regulation Of T Cell Activation Small GTPase Mediated Signal Transduction Positive Regulation Of Cell Activation Regulation Of Cell Adhesion Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Immune Response Positive Regulation Of Lamellipodium Organization Signal Transduction Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Positive Regulation Of Protein Metabolic Process Intracellular Signal Transduction Positive Regulation Of Neutrophil Chemotaxis Regulation Of Lamellipodium Assembly Positive Regulation Of Metabolic Process Regulation Of Lymphocyte Activation Response To Stress Regulation Of Immune System Process Positive Regulation Of Granulocyte Chemotaxis Innate Immune Response Blood Coagulation Defense Response Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Hemostasis Signaling Response To Stimulus Regulation Of Neutrophil Chemotaxis Regulation Of Signal Transduction Regulation Of Neutrophil Migration Cell Communication Regulation Of Immune Response	Immune System Process Regulation Of Immune System Process Regulation Of Immune Response Regulation Of Cell Activation Positive Regulation Of Cell Activation Regulation Of Lymphocyte Activation Positive Regulation Of Immune System Process Regulation Of T Cell Activation Positive Regulation Of Immune Response Cell Activation Immune Response-regulating Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Cell-cell Adhesion Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Cell Adhesion Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Cell Adhesion Lymphocyte Activation Homotypic Cell-cell Adhesion Leukocyte Activation T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Hemopoiesis Defense Response Single Organismal Cell-cell Adhesion Leukocyte Cell-cell Adhesion Immune System Development Leukocyte Differentiation T Cell Receptor Signaling Pathway T Cell Costimulation Immune Response T Cell Differentiation Lymphocyte Differentiation Innate Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway T Cell Differentiation In Thymus Positive Regulation Of Signal Transduction Organ Development Response To Stress Response To Stimulus Signal Transduction Regulation Of Body Fluid Levels Leukocyte Migration Cell Adhesion Positive Regulation Of Gamma-delta T Cell Differentiation
Tagcloud ?		abolish atypical beta2 chemotaxis cpypp dock5 fmlf gef gefs gtpase guanine integrin invading kill lacking leukocytes migrate motile net nets neutrophil neutrophils normally participate pathogens pma rac ros	already annotation annotations autoimmunity b6 cd3 characteristically chip coding elements encode encodes encyclopedia enrich gencode intron manual marks project qrt quantification seq spatially supported t1d tcr throughput utilized wealth
Tagcloud (Difference) ?		abolish atypical beta2 chemotaxis cpypp dock5 fmlf gef gefs gtpase guanine integrin invading kill lacking leukocytes migrate motile net nets neutrophil neutrophils normally participate pathogens pma rac ros	already annotation annotations autoimmunity b6 cd3 characteristically chip coding elements encode encodes encyclopedia enrich gencode intron manual marks project qrt quantification seq spatially supported t1d tcr throughput utilized wealth
Tagcloud (Intersection) ?