DOCK2

Gene Name		dedicator of cytokinesis 2
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Gene Ontology Annotations	Cellular Component	Cytosol Cytoskeleton Endomembrane System Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Rac GTPase Activator Activity Rac Guanyl-nucleotide Exchange Factor Activity T Cell Receptor Binding
	Biological Process	Membrane Raft Polarization Establishment Of T Cell Polarity Immunological Synapse Formation Myeloid Dendritic Cell Activation Involved In Immune Response Chemotaxis Small GTPase Mediated Signal Transduction Viral Process Actin Cytoskeleton Organization Positive Regulation Of Rac GTPase Activity Macropinocytosis Positive Thymic T Cell Selection Negative Thymic T Cell Selection Alpha-beta T Cell Proliferation Regulation Of Defense Response To Virus By Virus Positive Regulation Of Phagocytosis
Pathways		HIV Infection Host Interactions of HIV factors The role of Nef in HIV-1 replication and disease pathogenesis Factors involved in megakaryocyte development and platelet production Nef and signal transduction
Drugs
Diseases
GWAS		Protein quantitative trait loci ( 18464913)
Protein-protein Interactions		25 interactors: CALCOCO2 CCNDBP1 CD247 CRKL HNRNPK KHDRBS1 KHDRBS2 KRT40 KRTAP10-1 KRTAP10-3 KRTAP10-8 KRTAP10-9 KRTAP4-2 KRTAP5-9 KRTAP9-2 KRTAP9-4 MDFI MTUS2 NOTCH2NL PAK2 PLSCR1 RAC1 RAC2 TRIM23 VAV1
Entrez ID		1794
HPRD ID		09121
Ensembl ID		ENSG00000134516
Uniprot IDs		Q5XG91 Q92608
PDB IDs		2RQR 2YIN 3A98 3B13
Enriched GO Terms of Interacting Partners?		T Cell Costimulation Regulation Of Defense Response To Virus By Virus Viral Process Platelet Activation Positive Regulation Of T Cell Activation Regulation Of Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Immune System Process Positive Regulation Of Cell-cell Adhesion Regulation Of Hydrogen Peroxide Metabolic Process Regulation Of Defense Response To Virus Fc Receptor Signaling Pathway Regulation Of Respiratory Burst Positive Regulation Of Catalytic Activity Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Lamellipodium Assembly Regulation Of T Cell Activation Small GTPase Mediated Signal Transduction Positive Regulation Of Cell Activation Regulation Of Cell Adhesion Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Immune Response Positive Regulation Of Lamellipodium Organization Signal Transduction Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Positive Regulation Of Protein Metabolic Process Intracellular Signal Transduction Positive Regulation Of Neutrophil Chemotaxis Regulation Of Lamellipodium Assembly Positive Regulation Of Metabolic Process Regulation Of Lymphocyte Activation Response To Stress Regulation Of Immune System Process Positive Regulation Of Granulocyte Chemotaxis Innate Immune Response Blood Coagulation Defense Response Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Hemostasis Signaling Response To Stimulus Regulation Of Neutrophil Chemotaxis Regulation Of Signal Transduction Regulation Of Neutrophil Migration Cell Communication Regulation Of Immune Response
Tagcloud ?		abolish atypical beta2 chemotaxis cpypp dock5 fmlf gef gefs gtpase guanine integrin invading kill lacking leukocytes migrate motile net nets neutrophil neutrophils normally participate pathogens pma rac ros