DOCK2 and KRTAP5-9

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		DOCK2	KRTAP5-9
Gene Name		dedicator of cytokinesis 2	keratin associated protein 5-9
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Cytoskeleton Endomembrane System Membrane Extracellular Vesicular Exosome	Keratin Filament
	Molecular Function	Protein Binding Rac GTPase Activator Activity Rac Guanyl-nucleotide Exchange Factor Activity T Cell Receptor Binding	Protein Binding
	Biological Process	Membrane Raft Polarization Establishment Of T Cell Polarity Immunological Synapse Formation Myeloid Dendritic Cell Activation Involved In Immune Response Chemotaxis Small GTPase Mediated Signal Transduction Viral Process Actin Cytoskeleton Organization Positive Regulation Of Rac GTPase Activity Macropinocytosis Positive Thymic T Cell Selection Negative Thymic T Cell Selection Alpha-beta T Cell Proliferation Regulation Of Defense Response To Virus By Virus Positive Regulation Of Phagocytosis	Epidermis Development
Pathways		HIV Infection Host Interactions of HIV factors The role of Nef in HIV-1 replication and disease pathogenesis Factors involved in megakaryocyte development and platelet production Nef and signal transduction
Drugs
Diseases
GWAS		Protein quantitative trait loci ( 18464913)
Protein-Protein Interactions		25 interactors: CALCOCO2 CCNDBP1 CD247 CRKL HNRNPK KHDRBS1 KHDRBS2 KRT40 KRTAP10-1 KRTAP10-3 KRTAP10-8 KRTAP10-9 KRTAP4-2 KRTAP5-9 KRTAP9-2 KRTAP9-4 MDFI MTUS2 NOTCH2NL PAK2 PLSCR1 RAC1 RAC2 TRIM23 VAV1	103 interactors: ADAMTSL4 ALPP ATG9A BEX2 BMP7 C10orf62 C11orf87 C19orf66 CARKD CATSPER1 CHIC2 CHRD CKS1B CNNM3 COMT CRCT1 CTSZ CXCL16 DHRS1 DMRT3 DOCK2 FAH FAM124B FAM161A FAM74A4 FAM76B GLRX3 GNE HOXA1 HOXB9 HPCAL1 HSPD1 JOSD1 KLHL38 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP12-2 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP5-6 KRTAP9-2 KRTAP9-4 LCE1B LCE2A LCE3C LCE3E LCE4A LY6H MAPKBP1 MEOX2 NCLN NLK NMU NOTCH2NL NPBWR2 NPDC1 NTM NTN4 NUFIP2 OTX1 P2RX4 PCSK5 PFKL PGLS POM121L8P PRKAB2 PSMA1 PTPMT1 PVRL2 RAMP3 RGS20 RNF111 SCARB1 SDC3 SDCBP SLC22A23 SLC25A10 SMCP SPINK2 SPRY2 TBC1D10C TBC1D16 TCEA2 TCEANC TOMM22 TYRO3 WDYHV1 YIPF3 ZBTB24 ZFYVE21 ZNF124 ZNF266 ZNF417 ZNF439 ZNF581 ZNF587
Entrez ID		1794	3846
HPRD ID		09121	01008
Ensembl ID		ENSG00000134516	ENSG00000254997
Uniprot IDs		Q5XG91 Q92608	P26371
PDB IDs		2RQR 2YIN 3A98 3B13
Enriched GO Terms of Interacting Partners?		T Cell Costimulation Regulation Of Defense Response To Virus By Virus Viral Process Platelet Activation Positive Regulation Of T Cell Activation Regulation Of Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Immune System Process Positive Regulation Of Cell-cell Adhesion Regulation Of Hydrogen Peroxide Metabolic Process Regulation Of Defense Response To Virus Fc Receptor Signaling Pathway Regulation Of Respiratory Burst Positive Regulation Of Catalytic Activity Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Lamellipodium Assembly Regulation Of T Cell Activation Small GTPase Mediated Signal Transduction Positive Regulation Of Cell Activation Regulation Of Cell Adhesion Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Immune Response Positive Regulation Of Lamellipodium Organization Signal Transduction Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Positive Regulation Of Protein Metabolic Process Intracellular Signal Transduction Positive Regulation Of Neutrophil Chemotaxis Regulation Of Lamellipodium Assembly Positive Regulation Of Metabolic Process Regulation Of Lymphocyte Activation Response To Stress Regulation Of Immune System Process Positive Regulation Of Granulocyte Chemotaxis Innate Immune Response Blood Coagulation Defense Response Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Hemostasis Signaling Response To Stimulus Regulation Of Neutrophil Chemotaxis Regulation Of Signal Transduction Regulation Of Neutrophil Migration Cell Communication Regulation Of Immune Response	Keratinization Keratinocyte Differentiation Pattern Specification Process Epidermal Cell Differentiation Developmental Process Positive Regulation Of Immune Response To Tumor Cell Adhesion Of Symbiont To Host Locomotion Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Muscle Hypertrophy Organ Development Cell Recognition Skin Development Multicellular Organismal Development Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Anterior/posterior Pattern Specification Cell Differentiation System Development Epidermis Development Transcription, DNA-templated
Tagcloud ?		abolish atypical beta2 chemotaxis cpypp dock5 fmlf gef gefs gtpase guanine integrin invading kill lacking leukocytes migrate motile net nets neutrophil neutrophils normally participate pathogens pma rac ros
Tagcloud (Difference) ?		abolish atypical beta2 chemotaxis cpypp dock5 fmlf gef gefs gtpase guanine integrin invading kill lacking leukocytes migrate motile net nets neutrophil neutrophils normally participate pathogens pma rac ros
Tagcloud (Intersection) ?