DOCK2 and CCNDBP1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		DOCK2	CCNDBP1
Gene Name		dedicator of cytokinesis 2	cyclin D-type binding-protein 1
Image
Gene Ontology Annotations	Cellular Component	Cytosol Cytoskeleton Endomembrane System Membrane Extracellular Vesicular Exosome	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Protein Binding Rac GTPase Activator Activity Rac Guanyl-nucleotide Exchange Factor Activity T Cell Receptor Binding	Protein Binding
	Biological Process	Membrane Raft Polarization Establishment Of T Cell Polarity Immunological Synapse Formation Myeloid Dendritic Cell Activation Involved In Immune Response Chemotaxis Small GTPase Mediated Signal Transduction Viral Process Actin Cytoskeleton Organization Positive Regulation Of Rac GTPase Activity Macropinocytosis Positive Thymic T Cell Selection Negative Thymic T Cell Selection Alpha-beta T Cell Proliferation Regulation Of Defense Response To Virus By Virus Positive Regulation Of Phagocytosis	Cell Cycle Regulation Of Cell Cycle
Pathways		HIV Infection Host Interactions of HIV factors The role of Nef in HIV-1 replication and disease pathogenesis Factors involved in megakaryocyte development and platelet production Nef and signal transduction
Drugs
Diseases
GWAS		Protein quantitative trait loci ( 18464913)
Protein-Protein Interactions		25 interactors: CALCOCO2 CCNDBP1 CD247 CRKL HNRNPK KHDRBS1 KHDRBS2 KRT40 KRTAP10-1 KRTAP10-3 KRTAP10-8 KRTAP10-9 KRTAP4-2 KRTAP5-9 KRTAP9-2 KRTAP9-4 MDFI MTUS2 NOTCH2NL PAK2 PLSCR1 RAC1 RAC2 TRIM23 VAV1	70 interactors: AMPD2 ARHGAP22 ATP4B C22orf23 C6orf226 CCDC108 CCDC146 CCND1 CDK18 CNNM3 CUL5 DMRT3 DOCK2 FAM110A FAM64A FAM74A4 GLIDR GRAP2 GSTK1 ILF2 IMP3 MAP2K2 MOS MRPL15 MRPS9 NAIF1 NANOS2 NEURL3 NUDCD3 PAXIP1 PIAS2 PMP2 PSMB10 PTF1A RBP5 RPL28 RPL39L RPLP0 RPS28 SIRT6 SPG7 STK25 SYF2 TEAD4 THAP10 THAP7 TMEM120B TRAPPC5 TTC23 TYMSOS ZBTB24 ZGPAT ZNF124 ZNF136 ZNF169 ZNF20 ZNF230 ZNF334 ZNF394 ZNF439 ZNF490 ZNF555 ZNF564 ZNF581 ZNF627 ZNF670 ZNF697 ZNF707 ZNRF2P1 ZSCAN26
Entrez ID		1794	23582
HPRD ID		09121	06156
Ensembl ID		ENSG00000134516
Uniprot IDs		Q5XG91 Q92608	O95273
PDB IDs		2RQR 2YIN 3A98 3B13	3AY5
Enriched GO Terms of Interacting Partners?		T Cell Costimulation Regulation Of Defense Response To Virus By Virus Viral Process Platelet Activation Positive Regulation Of T Cell Activation Regulation Of Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Immune System Process Positive Regulation Of Cell-cell Adhesion Regulation Of Hydrogen Peroxide Metabolic Process Regulation Of Defense Response To Virus Fc Receptor Signaling Pathway Regulation Of Respiratory Burst Positive Regulation Of Catalytic Activity Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Lamellipodium Assembly Regulation Of T Cell Activation Small GTPase Mediated Signal Transduction Positive Regulation Of Cell Activation Regulation Of Cell Adhesion Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Immune Response Positive Regulation Of Lamellipodium Organization Signal Transduction Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Positive Regulation Of Protein Metabolic Process Intracellular Signal Transduction Positive Regulation Of Neutrophil Chemotaxis Regulation Of Lamellipodium Assembly Positive Regulation Of Metabolic Process Regulation Of Lymphocyte Activation Response To Stress Regulation Of Immune System Process Positive Regulation Of Granulocyte Chemotaxis Innate Immune Response Blood Coagulation Defense Response Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Hemostasis Signaling Response To Stimulus Regulation Of Neutrophil Chemotaxis Regulation Of Signal Transduction Regulation Of Neutrophil Migration Cell Communication Regulation Of Immune Response	Gene Expression RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process RNA Metabolic Process Transcription, DNA-templated Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Metabolic Process Translational Termination Translational Elongation Cellular Protein Complex Disassembly Protein Complex Disassembly Regulation Of Cellular Process Translational Initiation MRNA Catabolic Process Cellular Process Negative Regulation Of Cell Cycle RNA Catabolic Process Translation Viral Transcription Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay SRP-dependent Cotranslational Protein Targeting To Membrane Mitotic DNA Damage Checkpoint Cotranslational Protein Targeting To Membrane Protein Targeting To ER Viral Process Mitotic DNA Integrity Checkpoint Establishment Of Protein Localization To Endoplasmic Reticulum Negative Regulation Of Meiotic Cell Cycle Positive Regulation Of Histone H3-K36 Methylation Establishment Of Meiotic Spindle Orientation Negative Regulation Of Metaphase/anaphase Transition Of Meiotic Cell Cycle Protein Localization To Endoplasmic Reticulum Regulation Of Meiosis Cellular Protein Metabolic Process Myeloid Dendritic Cell Activation Involved In Immune Response Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide
Tagcloud ?		abolish atypical beta2 chemotaxis cpypp dock5 fmlf gef gefs gtpase guanine integrin invading kill lacking leukocytes migrate motile net nets neutrophil neutrophils normally participate pathogens pma rac ros	astrocyte astrocytes c6 cerebral challenge cns conditioned cortex designed distribution dynamic elucidate injection interactor lipopolysaccharide lps media neuroinflammation neuronal p29 pc12 pre silencing sirna splicing strategy strongly syf2 upregulation
Tagcloud (Difference) ?		abolish atypical beta2 chemotaxis cpypp dock5 fmlf gef gefs gtpase guanine integrin invading kill lacking leukocytes migrate motile net nets neutrophil neutrophils normally participate pathogens pma rac ros	astrocyte astrocytes c6 cerebral challenge cns conditioned cortex designed distribution dynamic elucidate injection interactor lipopolysaccharide lps media neuroinflammation neuronal p29 pc12 pre silencing sirna splicing strategy strongly syf2 upregulation
Tagcloud (Intersection) ?