DOCK2 and PLSCR1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		DOCK2	PLSCR1
Gene Name		dedicator of cytokinesis 2	phospholipid scramblase 1
Image
Gene Ontology Annotations	Cellular Component	Cytosol Cytoskeleton Endomembrane System Membrane Extracellular Vesicular Exosome	Nucleus Nucleolus Golgi Apparatus Cytosol Plasma Membrane Integral Component Of Plasma Membrane Membrane Extracellular Matrix Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Rac GTPase Activator Activity Rac Guanyl-nucleotide Exchange Factor Activity T Cell Receptor Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Epidermal Growth Factor Receptor Binding Calcium Ion Binding Protein Binding SH3 Domain Binding Phospholipid Scramblase Activity Enzyme Binding CD4 Receptor Binding
	Biological Process	Membrane Raft Polarization Establishment Of T Cell Polarity Immunological Synapse Formation Myeloid Dendritic Cell Activation Involved In Immune Response Chemotaxis Small GTPase Mediated Signal Transduction Viral Process Actin Cytoskeleton Organization Positive Regulation Of Rac GTPase Activity Macropinocytosis Positive Thymic T Cell Selection Negative Thymic T Cell Selection Alpha-beta T Cell Proliferation Regulation Of Defense Response To Virus By Virus Positive Regulation Of Phagocytosis	Phosphatidylserine Biosynthetic Process Apoptotic Process Acute-phase Response Positive Regulation Of Gene Expression Phospholipid Scrambling Platelet Activation Regulation Of Mast Cell Activation Response To Interferon-beta Negative Regulation Of Viral Genome Replication Positive Regulation Of Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Defense Response To Virus Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity
Pathways		HIV Infection Host Interactions of HIV factors The role of Nef in HIV-1 replication and disease pathogenesis Factors involved in megakaryocyte development and platelet production Nef and signal transduction
Drugs
Diseases
GWAS		Protein quantitative trait loci ( 18464913)
Protein-Protein Interactions		25 interactors: CALCOCO2 CCNDBP1 CD247 CRKL HNRNPK KHDRBS1 KHDRBS2 KRT40 KRTAP10-1 KRTAP10-3 KRTAP10-8 KRTAP10-9 KRTAP4-2 KRTAP5-9 KRTAP9-2 KRTAP9-4 MDFI MTUS2 NOTCH2NL PAK2 PLSCR1 RAC1 RAC2 TRIM23 VAV1	125 interactors: ABL1 ADAMTSL4 ADCY7 ANXA11 APP ARNT2 ATG12 ATN1 BACE1 BCL6B C10orf10 C10orf54 C10orf62 CATSPER1 CCDC33 CCER1 CDC42EP1 CHRD CNTFR CPSF3L CPSF6 CRK CRKL CRY1 CTBP1-AS2 CTSZ DAZAP2 DEF6 DHRS1 DLK2 DMRT3 DOCK2 DTX2 EFEMP2 EGFR ENKD1 EP300 ESR2 EWSR1 EXD3 FAM103A1 FBLN1 FBXL18 FRAT1 FRS3 GDPD5 GLRX3 GNAI2 GPRIN2 HEY2 HOXA1 HOXA9 HOXB6 HRG ILF3 IP6K2 KIAA1683 KIF1A KRTAP10-11 KRTAP10-3 KRTAP10-9 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP5-6 KRTAP9-2 LASP1 LCE2D LCE3C LCE4A LGALS9C LINC00663 LINC01547 LONRF1 MAPK6 MED15 MGAT5B MVP NECAP2 NEU4 NOC4L NPDC1 NR0B2 NTN4 OGDH P2RY6 PCED1A PGLS PHLDA1 PITX1 PKD2 PLSCR3 PLSCR4 PML PRKCD PRR13 RASD1 RBL1 RERE RGS3 SCNM1 SF1 SHC1 SLC25A6 SLC35A2 SLPI SMARCC1 SMCP SPATA8 SPG7 SPRY2 SRC STK16 TFG TRAF4 TRIM42 VASP VPS37C YIPF3 ZBTB16 ZNF417 ZNF581 ZNF587 ZNF638 ZNF764
Entrez ID		1794	5359
HPRD ID		09121	08855
Ensembl ID		ENSG00000134516	ENSG00000188313
Uniprot IDs		Q5XG91 Q92608	B4DTE8 O15162
PDB IDs		2RQR 2YIN 3A98 3B13	1Y2A
Enriched GO Terms of Interacting Partners?		T Cell Costimulation Regulation Of Defense Response To Virus By Virus Viral Process Platelet Activation Positive Regulation Of T Cell Activation Regulation Of Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Immune System Process Positive Regulation Of Cell-cell Adhesion Regulation Of Hydrogen Peroxide Metabolic Process Regulation Of Defense Response To Virus Fc Receptor Signaling Pathway Regulation Of Respiratory Burst Positive Regulation Of Catalytic Activity Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Lamellipodium Assembly Regulation Of T Cell Activation Small GTPase Mediated Signal Transduction Positive Regulation Of Cell Activation Regulation Of Cell Adhesion Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Immune Response Positive Regulation Of Lamellipodium Organization Signal Transduction Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Positive Regulation Of Protein Metabolic Process Intracellular Signal Transduction Positive Regulation Of Neutrophil Chemotaxis Regulation Of Lamellipodium Assembly Positive Regulation Of Metabolic Process Regulation Of Lymphocyte Activation Response To Stress Regulation Of Immune System Process Positive Regulation Of Granulocyte Chemotaxis Innate Immune Response Blood Coagulation Defense Response Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Hemostasis Signaling Response To Stimulus Regulation Of Neutrophil Chemotaxis Regulation Of Signal Transduction Regulation Of Neutrophil Migration Cell Communication Regulation Of Immune Response	Regulation Of Nitrogen Compound Metabolic Process Organ Development RNA Metabolic Process Transcription, DNA-templated Regulation Of Kinase Activity Enzyme Linked Receptor Protein Signaling Pathway Gene Expression Developmental Process RNA Biosynthetic Process Multicellular Organismal Development Regulation Of Protein Kinase Activity Regulation Of Transcription, DNA-templated Regulation Of Signaling Cellular Response To Organic Substance ERBB Signaling Pathway Regulation Of Nucleic Acid-templated Transcription System Development Regulation Of RNA Biosynthetic Process Cellular Response To Growth Factor Stimulus Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Response To Growth Factor Cellular Macromolecule Biosynthetic Process Regulation Of Signal Transduction Regulation Of Protein Phosphorylation Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Macromolecule Biosynthetic Process Central Nervous System Development Response To Organic Substance Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Anatomical Structure Development Pattern Specification Process Cellular Process Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Phosphorylation Fibroblast Growth Factor Receptor Signaling Pathway Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of MAPK Cascade Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Protein Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of MAPK Cascade Cellular Response To Fibroblast Growth Factor Stimulus Activation Of Protein Kinase Activity Platelet Activation
Tagcloud ?		abolish atypical beta2 chemotaxis cpypp dock5 fmlf gef gefs gtpase guanine integrin invading kill lacking leukocytes migrate motile net nets neutrophil neutrophils normally participate pathogens pma rac ros	actions adaptor adding anchorage attenuation blocking colorectal crc crcs dephosphorylation effectors erks g1 ht29 led monoclonal np1 overexpressed phospholipid retinoblastoma scramblase serve shc src terminus trafficking treating tumorigenesis tumorigenic
Tagcloud (Difference) ?		abolish atypical beta2 chemotaxis cpypp dock5 fmlf gef gefs gtpase guanine integrin invading kill lacking leukocytes migrate motile net nets neutrophil neutrophils normally participate pathogens pma rac ros	actions adaptor adding anchorage attenuation blocking colorectal crc crcs dephosphorylation effectors erks g1 ht29 led monoclonal np1 overexpressed phospholipid retinoblastoma scramblase serve shc src terminus trafficking treating tumorigenesis tumorigenic
Tagcloud (Intersection) ?