GRIK2 and CTNND1

Number of citations of the paper that reports this interaction (PMID 12151522)
27

Data Source:
HPRD (in vivo, in vitro)

		GRIK2	CTNND1
Gene Name		glutamate receptor, ionotropic, kainate 2	catenin (cadherin-associated protein), delta 1
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Postsynaptic Density Cell Junction Dendrite Dendrite Cytoplasm Kainate Selective Glutamate Receptor Complex Presynaptic Membrane Terminal Bouton Perikaryon Postsynaptic Membrane	Nucleus Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Zonula Adherens Lamellipodium Growth Cone Midbody Dendritic Spine Synapse Extracellular Vesicular Exosome
	Molecular Function	Extracellular-glutamate-gated Ion Channel Activity Kainate Selective Glutamate Receptor Activity PDZ Domain Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding Protein Homodimerization Activity	Receptor Binding Protein Binding Protein Kinase Binding Cadherin Binding
	Biological Process	Behavioral Fear Response Transport Cellular Calcium Ion Homeostasis Intracellular Protein Transport Glutamate Receptor Signaling Pathway Synaptic Transmission Neuronal Action Potential Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Receptor Clustering Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Regulation Of JNK Cascade Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Short-term Neuronal Synaptic Plasticity Regulation Of Synaptic Transmission Positive Regulation Of Synaptic Transmission Neuron Apoptotic Process Negative Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Inhibitory Postsynaptic Membrane Potential	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Cell Adhesion Brain Development Wnt Signaling Pathway Single Organismal Cell-cell Adhesion Cell Junction Assembly Adherens Junction Organization Cell-cell Junction Organization Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		Activation of Kainate Receptors upon glutamate binding Activation of Ca-permeable Kainate Receptor Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Activation of Na-permeable Kainate Receptors Ionotropic activity of Kainate Receptors Transmission across Chemical Synapses	Cell junction organization Cell-cell junction organization Signaling by VEGF Adherens junctions interactions VEGFR2 mediated vascular permeability VEGFA-VEGFR2 Pathway
Drugs		L-Glutamic Acid Butabarbital Butalbital Talbutal Pentobarbital Secobarbital Metharbital Thiopental Primidone Methylphenobarbital Phenobarbital Amobarbital Aprobarbital Butethal Heptabarbital Hexobarbital Barbital Barbituric acid derivative Domoic Acid Quisqualate 2s,4r-4-Methylglutamate
Diseases
GWAS		Biochemical measures ( 19260141) Cardiac hypertrophy ( 21348951) Obesity-related traits ( 23251661) Obsessive-compulsive disorder ( 22889921) Palmitic acid (16:0) plasma levels ( 23362303) Renal function-related traits (eGRFcrea) ( 22797727)
Protein-Protein Interactions		18 interactors: CALCOCO1 CASK CDH2 CTNNB1 CTNND1 DLG1 DLG3 DLG4 GRIA1 GRID2 GRIK4 GRIK5 GRIP1 LIN7B PICK1 PRKAA1 SDCBP TRIM25	26 interactors: ACTA1 APP CDH1 CDH24 CDH3 CDH5 COL17A1 CTTN EGFR ERBB2IP FER GRIK2 GSK3B JUP KCTD6 LCK MTNR1B MUC1 PSEN1 PTPN6 PTPRJ PTPRM SNCA SRC YWHAG ZBTB33
Entrez ID		2898	1500
HPRD ID		00692	03026
Ensembl ID		ENSG00000164418	ENSG00000198561
Uniprot IDs		A8K0H7 F8WEZ8 Q13002 Q8IY40	C9JZR2 O60716
PDB IDs		3QXM	3L6X 3L6Y
Enriched GO Terms of Interacting Partners?		Synaptic Transmission Cell-cell Signaling Receptor Clustering Establishment Or Maintenance Of Apical/basal Cell Polarity Protein Localization To Membrane Signaling Cell Communication Receptor Localization To Synapse Synaptic Transmission, Glutamatergic Ionotropic Glutamate Receptor Signaling Pathway Nucleotide Phosphorylation Glutamate Receptor Signaling Pathway Neuron-neuron Synaptic Transmission Cellular Protein Localization Protein Localization Protein Localization To Synapse Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Neuron Differentiation Signal Transduction Neurogenesis Nervous System Development Membrane Organization Response To External Stimulus Regulation Of Signaling Cell Surface Receptor Signaling Pathway Regulation Of Vesicle-mediated Transport Generation Of Neurons Establishment Or Maintenance Of Cell Polarity Maintenance Of Apical/basal Cell Polarity Cell Junction Assembly Negative Regulation Of Signaling Cellular Response To Stimulus Cell-cell Junction Organization Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Excitatory Postsynaptic Membrane Potential Cellular Localization Cell Development Regulation Of Postsynaptic Membrane Potential Response To Stimulus Adherens Junction Organization Maintenance Of Cell Polarity Positive Regulation Of Cellular Metabolic Process System Development Regulation Of Membrane Potential Wnt Signaling Pathway Neuron Development Positive Regulation Of Metabolic Process Regulation Of Synaptic Transmission Regulation Of Cellular Process Long Term Synaptic Depression	Cell Adhesion Adherens Junction Organization Regulation Of Signaling Single Organismal Cell-cell Adhesion Regulation Of Signal Transduction Regulation Of Cellular Localization Regulation Of Intracellular Transport Cellular Response To Organonitrogen Compound Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Junction Assembly Cell-cell Junction Organization Locomotion Cellular Response To Stimulus Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Regulation Of Cellular Amino Acid Metabolic Process Cell Surface Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Negative Regulation Of Protein Metabolic Process Signaling Negative Regulation Of Signaling Enzyme Linked Receptor Protein Signaling Pathway Cell Communication Regulation Of ERBB Signaling Pathway Regulation Of Cellular Protein Metabolic Process Apoptotic Process Regulation Of Cellular Ketone Metabolic Process Signal Transduction Regulation Of Protein Kinase Activity Response To Drug Programmed Cell Death Cell Death Death Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Developmental Process Negative Regulation Of Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Protein Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Response To Mechanical Stimulus Anatomical Structure Development Response To Organonitrogen Compound Response To External Stimulus Regulation Of Apoptotic Process Cell Migration Regulation Of Cell Proliferation Positive Regulation Of Intracellular Transport
Tagcloud ?		ancestry approaching asd asds autism candidate decade dutch failing finnish goldengate illumina intractable linkage mkl2 mlod reln replicate rs1881084 rs2518261 rs2885116 rs362780 rs756472 snd1 snp strengthen strengthened strict suggestive	abi1 atlas bitbucket ccnd3 doi driver drivers dx fbln2 figshare hindered http https identifies implies isoform ktsp m9 mitf myh11 org pparg prdm1 ralgds regulatorygenomicsupf signatures splicing switches transcript
Tagcloud (Difference) ?		ancestry approaching asd asds autism candidate decade dutch failing finnish goldengate illumina intractable linkage mkl2 mlod reln replicate rs1881084 rs2518261 rs2885116 rs362780 rs756472 snd1 snp strengthen strengthened strict suggestive	abi1 atlas bitbucket ccnd3 doi driver drivers dx fbln2 figshare hindered http https identifies implies isoform ktsp m9 mitf myh11 org pparg prdm1 ralgds regulatorygenomicsupf signatures splicing switches transcript
Tagcloud (Intersection) ?