GRIK2 and LIN7B

Number of citations of the paper that reports this interaction (PubMedID 12151522)
45

Data Source:
HPRD (in vitro, in vivo)

		GRIK2	LIN7B
Description		glutamate ionotropic receptor kainate type subunit 2	lin-7 cell polarity scaffold B
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GO Annotations	Cellular Component	Plasma Membrane Ionotropic Glutamate Receptor Complex Postsynaptic Density Membrane Axon Dendrite Dendrite Cytoplasm Kainate Selective Glutamate Receptor Complex Presynaptic Membrane Neuronal Cell Body Terminal Bouton Perikaryon Synapse Postsynaptic Membrane Mossy Fiber Rosette Hippocampal Mossy Fiber To CA3 Synapse Postsynaptic Density Membrane Glutamatergic Synapse	Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Basolateral Plasma Membrane Synapse Postsynaptic Membrane Anchoring Junction MPP7-DLG1-LIN7 Complex Presynapse Postsynaptic Density Membrane
	Molecular Function	SNARE Binding Glutamate-gated Receptor Activity Monoatomic Ion Channel Activity Extracellularly Glutamate-gated Ion Channel Activity Glutamate Receptor Activity Ligand-gated Monoatomic Ion Channel Activity Kainate Selective Glutamate Receptor Activity Glutamate-gated Calcium Ion Channel Activity PDZ Domain Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding Signaling Receptor Activity Identical Protein Binding Scaffold Protein Binding Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Protein Binding Protein Domain Specific Binding Protein-macromolecule Adaptor Activity
	Biological Process	Behavioral Fear Response Monoatomic Ion Transport Intracellular Calcium Ion Homeostasis Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Neuronal Action Potential Calcium-mediated Signaling Monoatomic Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Regulation Of Membrane Potential Receptor Clustering Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Regulation Of JNK Cascade Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Short-term Neuronal Synaptic Plasticity Modulation Of Chemical Synaptic Transmission Positive Regulation Of Synaptic Transmission Neuron Apoptotic Process Negative Regulation Of Synaptic Transmission, Glutamatergic Excitatory Postsynaptic Potential Inhibitory Postsynaptic Potential Modulation Of Excitatory Postsynaptic Potential Presynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Presynaptic Membrane Potential Detection Of Cold Stimulus Involved In Thermoception	Exocytosis Neurotransmitter Secretion Regulation Of Synaptic Assembly At Neuromuscular Junction Protein Transport Synaptic Vesicle Transport
Pathways		Activation of Na-permeable kainate receptors Activation of Ca-permeable Kainate Receptor	Dopamine Neurotransmitter Release Cycle RHO GTPases Activate Rhotekin and Rhophilins Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors
Drugs		Glutamic acid Butabarbital Butalbital Topiramate Talbutal Pentobarbital Secobarbital Metharbital Thiopental Primidone Methylphenobarbital Phenobarbital Amobarbital Aprobarbital Butobarbital Heptabarbital Hexobarbital Barbital Dihydro-2-thioxo-5-((5-(2-(trifluoromethyl)phenyl)-2-furanyl)methyl)-4,6(1H,5H)-pyrimidinedione Domoic Acid Quisqualic acid 2s,4r-4-Methylglutamate
Diseases		Nonsyndromic autosomal recessive mental retardation (NS-ARMR)
GWAS		A body shape index ( 34021172) Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Biochemical measures ( 19260141) Cardiac hypertrophy ( 21348951) Cerebral amyloid angiopathy x APOEe4 status interaction in Alzheimer’s disease ( 34020725) Emphysema imaging phenotypes ( 26030696) Heart rate response to recovery post exercise (20 sec) ( 29497042) Longevity (90 years and older) ( 25199915) Obesity-related traits ( 23251661) Obsessive-compulsive disorder ( 22889921) Palmitic acid (16:0) levels ( 23362303) Pursuit maintenance gain ( 29064472) Renal function-related traits (eGRFcrea) ( 22797727) Triglyceride levels x SSRI defined daily dose interaction in schizophrenia or bipolar disorder ( 33824429) Waist circumference adjusted for body mass index ( 34021172) Weight ( 28552196)
Interacting Genes		20 interacting genes: CALCOCO1 CASK CDH2 CTNNB1 CTNND1 DLG1 DLG3 DLG4 GRIA1 GRID2 GRIK1 GRIK4 GRIK5 GRIP1 LIN7B NETO1 PICK1 PRKAA1 SDCBP TRIM25	19 interacting genes: ABCA1 APBA1 ASIC3 BAIAP2 CASK DLG4 ENKD1 GNG13 GRIK2 GRIN2B KCNJ12 KCNJ4 MAK16 MPP7 NTAQ1 PSMB1 SNCA TCEANC TRAPPC12
Entrez ID		2898	64130
HPRD ID		00692	10040
Ensembl ID		ENSG00000164418	ENSG00000104863
Uniprot IDs		A0A8D9PH75 A8K0H7 Q13002 Q8IY40	Q9HAP6
PDB IDs		3QXM 5CMM	2DKR
Enriched GO Terms of Interacting Partners?		Postsynaptic Density Membrane Synapse Postsynaptic Membrane Chemical Synaptic Transmission Ionotropic Glutamate Receptor Signaling Pathway Trans-synaptic Signaling Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Synaptic Signaling Ligand-gated Ion Channel Signaling Pathway Glutamate Receptor Signaling Pathway Cell-cell Junction Presynaptic Membrane Ligand-gated Monoatomic Ion Channel Activity Cell-cell Signaling Signaling Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Cell Communication Adherens Junction Synaptic Transmission, Glutamatergic Modulation Of Chemical Synaptic Transmission Receptor Localization To Synapse Receptor Clustering Protein Localization To Synapse Kainate Selective Glutamate Receptor Complex Kainate Selective Glutamate Receptor Activity Regulation Of Cell Communication Regulation Of Signaling Regulation Of Membrane Potential AMPA Glutamate Receptor Complex Protein Localization To Membrane Ionotropic Glutamate Receptor Binding Protein Localization To Cell Junction Protein Localization To Postsynaptic Membrane Protein Localization To Postsynapse Plasma Membrane Localization Within Membrane Neuron Projection Intracellular Protein Localization Regulation Of Postsynaptic Membrane Potential Glutamate-gated Receptor Activity Basolateral Plasma Membrane Regulation Of Transport Postsynaptic Density Phosphatase Binding Regulation Of Biological Quality Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Cell-cell Adhesion Protein-containing Complex Localization Monoatomic Ion Channel Activity Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane	Modulation Of Chemical Synaptic Transmission Regulation Of Neuronal Synaptic Plasticity Modulation Of Excitatory Postsynaptic Potential Regulation Of Synaptic Plasticity PDZ Domain Binding Regulation Of Long-term Neuronal Synaptic Plasticity Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Membrane Potential Regulation Of Nervous System Process Ligand-gated Ion Channel Signaling Pathway Cellular Component Assembly Chemical Synaptic Transmission Positive Regulation Of Synaptic Transmission Glutamate Receptor Signaling Pathway Trans-synaptic Signaling Synaptic Signaling Protein-containing Complex Assembly Glutamate-gated Calcium Ion Channel Activity Excitatory Postsynaptic Potential Plasma Membrane Synapse Synaptic Membrane Scaffold Protein Binding Positive Regulation Of Protein-containing Complex Assembly Regulation Of Monoatomic Ion Transport Regulation Of Protein-containing Complex Assembly Protein-containing Complex Organization Protein Localization To Cell Junction Postsynaptic Membrane Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Protein Tetramerization Postsynaptic Density Schaffer Collateral - CA1 Synapse Regulation Of Postsynaptic Membrane Potential Neuron Projection Terminus Postsynaptic Density Membrane Detection Of Temperature Stimulus Involved In Sensory Perception Detection Of Temperature Stimulus Regulation Of Monoatomic Ion Transmembrane Transport Inward Rectifier Potassium Channel Activity Regulation Of System Process Dendrite Cytoplasm Monoatomic Ion Transport Synaptic Vesicle Metal Ion Transport Regulation Of Presynaptic Membrane Potential Cell-cell Signaling Excitatory Synapse Ligand-gated Monoatomic Ion Channel Activity
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