DCP2 and TRIM21

Number of citations of the paper that reports this interaction (PMID 18361920)
2

Data Source:
BioGRID (pull down, affinity chromatography technology)

		DCP2	TRIM21
Gene Name		decapping mRNA 2	tripartite motif containing 21
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasmic MRNA Processing Body Nucleoplasm Cytosol RISC Complex Cell Junction Intracellular Membrane-bounded Organelle	Cytoplasmic MRNA Processing Body Nucleus Nucleoplasm Cytoplasm Cytosol SCF Ubiquitin Ligase Complex Ribonucleoprotein Complex
	Molecular Function	RNA Binding Protein Binding Exoribonuclease Activity, Producing 5'-phosphomonoesters Manganese Ion Binding M7G(5')pppN Diphosphatase Activity	DNA Binding RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Identical Protein Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay MRNA Catabolic Process Gene Expression Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Histone MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	Protein Polyubiquitination Protein Monoubiquitination Cell Cycle Protein Ubiquitination Cytokine-mediated Signaling Pathway Protein Destabilization Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Negative Regulation Of Viral Transcription Innate Immune Response Positive Regulation Of Cell Cycle Positive Regulation Of Viral Entry Into Host Cell Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Autoubiquitination Interferon-gamma-mediated Signaling Pathway Protein Trimerization Negative Regulation Of Protein Deubiquitination Negative Regulation Of Viral Release From Host Cell
Pathways		Regulation of mRNA stability by proteins that bind AU-rich elements KSRP destabilizes mRNA ATF4 activates genes mRNA decay by 5' to 3' exoribonuclease Tristetraprolin (TTP) destabilizes mRNA PERK regulates gene expression Unfolded Protein Response (UPR) Deadenylation-dependent mRNA decay Butyrate Response Factor 1 (BRF1) destabilizes mRNA	Interferon gamma signaling Antigen processing: Ubiquitination & Proteasome degradation Regulation of innate immune responses to cytosolic DNA Cytosolic sensors of pathogen-associated DNA STING mediated induction of host immune responses Interferon Signaling Cytokine Signaling in Immune system Class I MHC mediated antigen processing & presentation Innate Immune System Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: AGO1 AGO2 DCP1A DCP1B NAGK POLA2 PSMB1 TRIM21 UPF1 UPF2	37 interactors: APC CASP8AP2 CDC34 CUL1 DAXX DCP2 DZIP3 FADD FBXW11 GRAP HLA-DRB1 IGHG1 IGHV4-31 IKBKB IRF8 MNAT1 NIF3L1 RBCK1 RNF111 SKP2 TRIM27 TRIM39 TRIM5 TRIM8 TROVE2 TXN2 UBC UBE2C UBE2D1 UBE2D2 UBE2H UBE2I UBE2L3 USP15 USP2 USP4 YWHAZ
Entrez ID		167227	6737
HPRD ID		13125	00170
Ensembl ID		ENSG00000172795	ENSG00000132109
Uniprot IDs		Q8IU60	P19474
PDB IDs			2IWG
Enriched GO Terms of Interacting Partners?		Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process MRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cellular Macromolecule Catabolic Process Aromatic Compound Catabolic Process Catabolic Process Negative Regulation Of Translation Involved In Gene Silencing By MiRNA MiRNA Metabolic Process Posttranscriptional Regulation Of Gene Expression Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Regulation Of Gene Expression, Epigenetic Gene Silencing By MiRNA Gene Expression Cellular Nitrogen Compound Metabolic Process Posttranscriptional Gene Silencing Nucleocytoplasmic Transport Nuclear Transport Regulation Of Translation Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Cellular Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Nitrogen Compound Metabolic Process Gene Silencing By RNA Negative Regulation Of Protein Metabolic Process MRNA Export From Nucleus RNA Export From Nucleus Negative Regulation Of Translation Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Protein Metabolic Process RNA Metabolic Process Gene Silencing MRNA Cleavage Involved In Gene Silencing By MiRNA Deadenylation-independent Decapping Of Nuclear-transcribed MRNA N-acetylmannosamine Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Protein Metabolic Process Nuclear Export MRNA Transport SiRNA Loading Onto RISC Involved In RNA Interference Negative Regulation Of Protein Deubiquitination Phosphatidylinositol-mediated Signaling RNA Transport Notch Signaling Pathway Positive Regulation Of Viral Entry Into Host Cell N-acetylneuraminate Catabolic Process RNA Localization	Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Catabolic Process Cellular Protein Modification Process Proteolysis Regulation Of Protein Ubiquitination Protein Metabolic Process Regulation Of Proteolysis Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Signal Transduction Mitotic Cell Cycle Process Protein K48-linked Ubiquitination Regulation Of Protein Metabolic Process Cell Cycle Cell Cycle Phase Transition Regulation Of Protein Catabolic Process Mitotic Cell Cycle Innate Immune Response Cell Cycle Process Immune Response-regulating Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To Stimulus TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Protein Ubiquitination MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Cell Communication Activation Of Innate Immune Response Regulation Of Signaling Positive Regulation Of Ubiquitin-protein Transferase Activity Cellular Metabolic Process Cell Surface Receptor Signaling Pathway Mitotic Cell Cycle Phase Transition Regulation Of Signal Transduction Positive Regulation Of Ligase Activity Response To Stimulus
Tagcloud ?		accumulate actively bodies cleared constant decay depots ends engaged eukaryotes fate gradually intensively localizes machinery mammalian membranous mrnas ms2 regular relieved residing starvation stationary storage tagging tails translational visualization	2ms 3ms 440ms addressable adjusting albia antibodies bead confounders corrected ekg erythematosus immunoassay lupus multicenter prolongation prolonged qt qtc reasons repolarization resting ro ro52 ro60 separately ss ssc univariate
Tagcloud (Difference) ?		accumulate actively bodies cleared constant decay depots ends engaged eukaryotes fate gradually intensively localizes machinery mammalian membranous mrnas ms2 regular relieved residing starvation stationary storage tagging tails translational visualization	2ms 3ms 440ms addressable adjusting albia antibodies bead confounders corrected ekg erythematosus immunoassay lupus multicenter prolongation prolonged qt qtc reasons repolarization resting ro ro52 ro60 separately ss ssc univariate
Tagcloud (Intersection) ?