DCP2 and POLA2

Number of citations of the paper that reports this interaction (PMID 15231747)
44

Data Source:
HPRD (two hybrid)

		DCP2	POLA2
Gene Name		decapping mRNA 2	polymerase (DNA directed), alpha 2, accessory subunit
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasmic MRNA Processing Body Nucleoplasm Cytosol RISC Complex Cell Junction Intracellular Membrane-bounded Organelle	Nucleoplasm Alpha DNA Polymerase:primase Complex Cytoplasm
	Molecular Function	RNA Binding Protein Binding Exoribonuclease Activity, Producing 5'-phosphomonoesters Manganese Ion Binding M7G(5')pppN Diphosphatase Activity	Molecular_function DNA Binding DNA-directed DNA Polymerase Activity Protein Heterodimerization Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay MRNA Catabolic Process Gene Expression Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Histone MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	Protein Import Into Nucleus, Translocation G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Telomere Maintenance Via Recombination Telomere Maintenance DNA Replication DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication Telomere Maintenance Via Semi-conservative Replication DNA Biosynthetic Process
Pathways		Regulation of mRNA stability by proteins that bind AU-rich elements KSRP destabilizes mRNA ATF4 activates genes mRNA decay by 5' to 3' exoribonuclease Tristetraprolin (TTP) destabilizes mRNA PERK regulates gene expression Unfolded Protein Response (UPR) Deadenylation-dependent mRNA decay Butyrate Response Factor 1 (BRF1) destabilizes mRNA	Activation of the pre-replicative complex Extension of Telomeres Activation of the pre-replicative complex Leading Strand Synthesis DNA strand elongation Polymerase switching DNA replication initiation Telomere Maintenance G1/S Transition Mitotic G1-G1/S phases E2F mediated regulation of DNA replication Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation Synthesis of DNA Chromosome Maintenance Lagging Strand Synthesis Processive synthesis on the lagging strand DNA Replication Pre-Initiation M/G1 Transition Telomere C-strand (Lagging Strand) Synthesis S Phase Cell Cycle, Mitotic Removal of the Flap Intermediate Inhibition of replication initiation of damaged DNA by RB1/E2F1
Drugs			Dacarbazine
Diseases
GWAS
Protein-Protein Interactions		10 interactors: AGO1 AGO2 DCP1A DCP1B NAGK POLA2 PSMB1 TRIM21 UPF1 UPF2	31 interactors: AKTIP APP ASCC2 ATP5C1 CPE CRELD1 DCP2 DDX24 DHX34 EIF6 EZH2 FAM219A FGFR3 FRZB HDAC6 HELB HGH1 IGFBP3 KCNE3 KLF6 LRPAP1 NHP2L1 NR4A1 PARP1 POLA1 PRPF38A RBM23 SETDB1 STK40 ULK2 XPNPEP1
Entrez ID		167227	23649
HPRD ID		13125	10160
Ensembl ID		ENSG00000172795
Uniprot IDs		Q8IU60	Q14181
PDB IDs			2KEB 4E2I
Enriched GO Terms of Interacting Partners?		Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process MRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cellular Macromolecule Catabolic Process Aromatic Compound Catabolic Process Catabolic Process Negative Regulation Of Translation Involved In Gene Silencing By MiRNA MiRNA Metabolic Process Posttranscriptional Regulation Of Gene Expression Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Regulation Of Gene Expression, Epigenetic Gene Silencing By MiRNA Gene Expression Cellular Nitrogen Compound Metabolic Process Posttranscriptional Gene Silencing Nucleocytoplasmic Transport Nuclear Transport Regulation Of Translation Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Cellular Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Nitrogen Compound Metabolic Process Gene Silencing By RNA Negative Regulation Of Protein Metabolic Process MRNA Export From Nucleus RNA Export From Nucleus Negative Regulation Of Translation Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Protein Metabolic Process RNA Metabolic Process Gene Silencing MRNA Cleavage Involved In Gene Silencing By MiRNA Deadenylation-independent Decapping Of Nuclear-transcribed MRNA N-acetylmannosamine Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Protein Metabolic Process Nuclear Export MRNA Transport SiRNA Loading Onto RISC Involved In RNA Interference Negative Regulation Of Protein Deubiquitination Phosphatidylinositol-mediated Signaling RNA Transport Notch Signaling Pathway Positive Regulation Of Viral Entry Into Host Cell N-acetylneuraminate Catabolic Process RNA Localization	RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression Developmental Growth Growth MRNA Metabolic Process DNA Replication, Synthesis Of RNA Primer Regulation Of Growth Cellular Response To Reactive Oxygen Species Regulation Of Binding Regulation Of Receptor Activity Organ Development Metabolic Process RNA Processing Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Cell Development Positive Regulation Of Programmed Cell Death Developmental Growth Involved In Morphogenesis Regulation Of Protein Binding Positive Regulation Of Cell Death Histone H3-K9 Modification Negative Regulation Of Epithelial Cell Differentiation Cellular Protein Modification Process Cellular Protein Metabolic Process Chromosome Organization Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Negative Regulation Of Hepatocyte Differentiation Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway Hsp90 Deacetylation Response To Oxidative Stress MRNA Processing RNA Biosynthetic Process Cochlea Development Response To Reactive Oxygen Species Negative Regulation Of Cell Differentiation Cellular Response To Oxidative Stress Lung Alveolus Development Macroautophagy Regulation Of Cell Differentiation System Development Cellular Response To Hydrogen Peroxide Positive Regulation Of Chaperone-mediated Protein Complex Assembly Leading Strand Elongation Synaptic Growth At Neuromuscular Junction Polyubiquitinated Misfolded Protein Transport
Tagcloud ?		accumulate actively bodies cleared constant decay depots ends engaged eukaryotes fate gradually intensively localizes machinery mammalian membranous mrnas ms2 regular relieved residing starvation stationary storage tagging tails translational visualization	beadchip ca125 carboplatin cdkn1b chek2 ck7 cyfra21 cytokinesis deserve exceptional fancd2 illumina krt7 lig3 mesothelioma nt5c obscure pemetrexed phosphorylase platinum pold1 prpf19 recq5 sensitize smrp sparcl1 transendothelial ts tymp
Tagcloud (Difference) ?		accumulate actively bodies cleared constant decay depots ends engaged eukaryotes fate gradually intensively localizes machinery mammalian membranous mrnas ms2 regular relieved residing starvation stationary storage tagging tails translational visualization	beadchip ca125 carboplatin cdkn1b chek2 ck7 cyfra21 cytokinesis deserve exceptional fancd2 illumina krt7 lig3 mesothelioma nt5c obscure pemetrexed phosphorylase platinum pold1 prpf19 recq5 sensitize smrp sparcl1 transendothelial ts tymp
Tagcloud (Intersection) ?