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RNF168 and H2AFX
Number of citations of the paper that reports this interaction (PMID
19500350
)
22
Data Source:
BioGRID
(enzymatic study)
RNF168
H2AFX
Gene Name
ring finger protein 168, E3 ubiquitin protein ligase
H2A histone family, member X
Image
Gene Ontology Annotations
Cellular Component
Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Cytoplasm
Site Of Double-strand Break
Chromosome, Telomeric Region
Nucleosome
Nuclear Chromatin
Condensed Nuclear Chromosome
Male Germ Cell Nucleus
XY Body
Nucleus
Nucleoplasm
Replication Fork
Site Of Double-strand Break
Extracellular Vesicular Exosome
Molecular Function
Chromatin Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Ligase Activity
Nucleosome Binding
Histone Binding
Ubiquitin Binding
K63-linked Polyubiquitin Binding
DNA Binding
Damaged DNA Binding
Protein Binding
Enzyme Binding
Histone Binding
Protein Heterodimerization Activity
Biological Process
Double-strand Break Repair
Ubiquitin-dependent Protein Catabolic Process
Cellular Response To DNA Damage Stimulus
Response To Ionizing Radiation
Protein Ubiquitination
Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter
Histone H2A Monoubiquitination
Interstrand Cross-link Repair
Histone H2A-K13 Ubiquitination
Histone H2A-K15 Ubiquitination
Isotype Switching
Positive Regulation Of DNA Repair
Protein K63-linked Ubiquitination
Histone H2A K63-linked Ubiquitination
DNA Damage Checkpoint
Double-strand Break Repair Via Homologous Recombination
DNA Repair
Double-strand Break Repair
Nucleosome Assembly
Cellular Response To DNA Damage Stimulus
Spermatogenesis
Response To Ionizing Radiation
Positive Regulation Of DNA Repair
Meiotic Cell Cycle
Pathways
RNA Polymerase I Chain Elongation
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
Mitotic Prophase
Regulatory RNA pathways
Deposition of new CENPA-containing nucleosomes at the centromere
Cellular Senescence
Signaling by Wnt
Amyloids
NoRC negatively regulates rRNA expression
Packaging Of Telomere Ends
RNF mutants show enhanced WNT signaling and proliferation
Homologous recombination repair of replication-independent double-strand breaks
ATM mediated phosphorylation of repair proteins
DNA Damage/Telomere Stress Induced Senescence
Chromosome Maintenance
ATM mediated response to DNA double-strand break
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
Chromatin organization
formation of the beta-catenin:TCF transactivating complex
Meiotic synapsis
Senescence-Associated Secretory Phenotype (SASP)
Chromatin modifying enzymes
Recruitment of repair and signaling proteins to double-strand breaks
SIRT1 negatively regulates rRNA Expression
Condensation of Prophase Chromosomes
MRN complex relocalizes to nuclear foci
RNA Polymerase I Promoter Clearance
Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks
M Phase
Telomere Maintenance
Nucleosome assembly
XAV939 inhibits tankyrase, stabilizing AXIN
Double-Strand Break Repair
DNA methylation
Transcriptional regulation by small RNAs
Meiotic recombination
RNA Polymerase I Transcription
Epigenetic regulation of gene expression
Negative epigenetic regulation of rRNA expression
Cell Cycle, Mitotic
PRC2 methylates histones and DNA
RMTs methylate histone arginines
TCF dependent signaling in response to WNT
Oxidative Stress Induced Senescence
Homologous Recombination Repair
RNA Polymerase I Promoter Opening
Signaling by WNT in cancer
Drugs
Diseases
GWAS
Fat distribution (HIV) (
21897333
)
Protein-Protein Interactions
12 interactors:
H2AFX
HIST2H2AC
JMJD1C
KDM4A
KIAA0368
LAPTM5
RABGEF1
RNF11
UBC
UBE2D3
UBE2E1
UBE2G2
45 interactors:
A2M
ACTB
ALG9
ATM
ATR
BARD1
BMI1
BRCA1
BRCA2
BRD1
CALM1
COPG1
DDX21
DHX9
KAT5
MASP1
MCPH1
MDC1
MRE11A
NBN
NCL
NGFR
OTUB1
PAXIP1
PBK
PPP1CA
PPP2R4
PRKDC
QARS
RNF168
RNF8
RPS6KA3
SMARCA4
SSRP1
SUPT16H
SUPT5H
TAF1C
TAF5L
TERF2
TIAM2
TOPORS
TP53BP1
TSSK6
WRN
XRCC6
Entrez ID
165918
3014
HPRD ID
08190
03465
Ensembl ID
ENSG00000163961
ENSG00000188486
Uniprot IDs
Q8IYW5
P16104
PDB IDs
3L11
4GB0
2D31
2DYP
3SHV
3SQD
3SZM
3U3Z
Enriched GO Terms of Interacting Partners
?
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Protein Catabolic Process
Protein K48-linked Ubiquitination
Protein Polyubiquitination
Cellular Macromolecule Catabolic Process
Proteolysis
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Catabolic Process
Negative Regulation Of Cytokine Production
ER-associated Ubiquitin-dependent Protein Catabolic Process
Cell Cycle Checkpoint
Protein Monoubiquitination
Negative Regulation Of Type I Interferon Production
Cellular Protein Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Chromatin Organization
Cellular Protein Modification Process
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Regulation Of DNA-templated Transcription In Response To Stress
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
TRIF-dependent Toll-like Receptor Signaling Pathway
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Negative Regulation Of Ubiquitin-protein Transferase Activity
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Negative Regulation Of Kit Signaling Pathway
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Ubiquitin-protein Transferase Activity
Positive Regulation Of Ligase Activity
Toll-like Receptor 4 Signaling Pathway
Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Regulation Of Ubiquitin-protein Transferase Activity
Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Cellular Response To Hypoxia
Cellular Response To Decreased Oxygen Levels
Negative Regulation Of Protein Ubiquitination
Chromosome Organization
Regulation Of Type I Interferon Production
Toll-like Receptor Signaling Pathway
Cellular Response To Oxygen Levels
Protein Metabolic Process
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
DNA Metabolic Process
Double-strand Break Repair
DNA Repair
Cellular Response To DNA Damage Stimulus
Chromosome Organization
DNA Recombination
Organelle Organization
Cellular Response To Stress
Response To Ionizing Radiation
Double-strand Break Repair Via Homologous Recombination
Recombinational Repair
Response To Radiation
Chromatin Organization
Response To Stress
Regulation Of Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Chromatin Modification
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Response To Abiotic Stimulus
Telomere Maintenance
Nitrogen Compound Metabolic Process
Positive Regulation Of Metabolic Process
Cell Cycle
Positive Regulation Of Cellular Metabolic Process
Signal Transduction In Response To DNA Damage
Regulation Of Protein Metabolic Process
Cellular Metabolic Process
Histone Modification
Signal Transduction By P53 Class Mediator
Response To Stimulus
Negative Regulation Of Cell Cycle
Regulation Of Cell Cycle
Cellular Response To Stimulus
Cellular Protein Modification Process
DNA Damage Response, Signal Transduction By P53 Class Mediator
Regulation Of Nitrogen Compound Metabolic Process
Peptidyl-amino Acid Modification
DNA Damage Checkpoint
Peptidyl-lysine Modification
Cell Cycle Process
Regulation Of Cellular Protein Metabolic Process
DNA Replication
Regulation Of Gene Expression
Response To Gamma Radiation
Negative Regulation Of Protein Metabolic Process
Histone Acetylation
Double-strand Break Repair Via Nonhomologous End Joining
Tagcloud
?
53bp1
atm
brca1
cdk1
comparatively
coordinates
cytosol
ddr
enables
exit
flanking
genotoxic
h2a
homologous
impairs
interphase
joining
kinetochores
ligases
localize
mitosis
mitotic
plk1
properly
recombination
rnf8
s1618
spatiotemporally
ubiquitinated
Tagcloud (Difference)
?
53bp1
atm
brca1
cdk1
comparatively
coordinates
cytosol
ddr
enables
exit
flanking
genotoxic
h2a
homologous
impairs
interphase
joining
kinetochores
ligases
localize
mitosis
mitotic
plk1
properly
recombination
rnf8
s1618
spatiotemporally
ubiquitinated
Tagcloud (Intersection)
?