DHX8 and PRPF40A

Number of citations of the paper that reports this interaction (PubMedID 34079125)
0

Data Source:
BioGRID (proximity labelling technology, two hybrid, two hybrid)

		DHX8	PRPF40A
Description		DEAH-box helicase 8	pre-mRNA processing factor 40A
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cytosol Nuclear Body U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome Ribonucleoprotein Complex	Nucleus Nucleoplasm U1 SnRNP Membrane Nuclear Matrix Nuclear Speck U2-type Prespliceosome
	Molecular Function	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Helicase Activity Protein Binding ATP Binding ATP-dependent Activity, Acting On RNA Hydrolase Activity ATP Hydrolysis Activity Identical Protein Binding	RNA Binding Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome RNA Processing MRNA Processing RNA Splicing	MRNA Splicing, Via Spliceosome MRNA Processing Cytoskeleton Organization Regulation Of Cell Shape RNA Splicing Cell Migration Regulation Of Cytokinesis MRNA Cis Splicing, Via Spliceosome Cell Division
Pathways		mRNA Splicing - Major Pathway	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535)	Heel bone mineral density ( 30598549) Memory dysfunction in frontotemporal lobe dementia ( 29724592) Metabolite levels ( 23823483) Pulse pressure ( 30224653) Refractive error ( 32231278)
Interacting Genes		12 interacting genes: BUB1B LUC7L2 MFAP1 PRPF38A PRPF40A RBM7 RBMX2 SAP30BP SRPK1 SRPK2 THOC1 UBC	132 interacting genes: ABI1 AKAP8L APBB1IP ARFGEF2 ASXL2 ATAD3A BAG6 BEND7 BRD4 CAP2 CCNL1 CCT2 CCT4 CCT7 CDK12 CDK13 CHD3 CHERP CPSF6 CT45A1 CUL1 CYFIP1 CYFIP2 DAAM1 DDIT4L DHX15 DHX8 DHX9 DIAPH1 DZIP1 DZIP1L ENAH ERG EVL FASLG FMN1 FMNL1 FMNL2 FMNL3 FN1 FNBP4 FRA10AC1 GAPDH HIPK1 HNRNPF HNRNPK HNRNPU HNRNPUL1 HSPB1 HSPG2 HTT IL1RAP KMT2B LARP7 LTBP3 MAP1LC3A MECP2 MMP11 NCKAP1L NKAP NKAPD1 NONO PCBP2 PDCD7 PECAM1 PFKL PIAS1 PIAS3 PIAS4 PICK1 PPIG PRKAR1A PSG5 PTBP1 PTPRF RBM39 RBMX2 RCC2 RLF RNF10 RPL4 RPLP0 SDCBP SDCBP2 SDK1 SERPINB9 SF1 SF3A1 SF3A2 SF3A3 SF3B2 SF3B3 SFPQ SMAD4 SNIP1 SNRNP70 SON SPMIP2 SREK1 SREK1IP1 SRPK2 STIM2 TCEAL9 TMEM132D U2AF1 U2AF2 U2SURP UBE2I UBE2K UBQLN1 UBQLN2 UBQLN4 UBR4 USP7 VASP VCL WAS WASF2 WASL WBP11 WBP4 WIPF1 XRCC6 YBX1 YLPM1 YWHAG ZCCHC10 ZCCHC8 ZFHX3 ZHX1 ZNF341 ZNF451
Entrez ID		1659	55660
HPRD ID		02672	10995
Ensembl ID		ENSG00000067596	ENSG00000196504
Uniprot IDs		B7Z8F4 F5H658 K7END7 Q05CV4 Q14562 Q86YB2	A0A7N4I394 A0A8Q3SIG7 A0A8V8TM61 F5H578 O75400
PDB IDs		2EQS 3I4U 5MQF 5XJC 6HYS 6HYT 6HYU 6ICZ 6QDV 7W59 7W5A 7W5B 8C6J 9FMD	1UZC 1YWI 1YWJ 1ZR7 2CQN 2DYF 2KZG 2L5F 2L9V 2LKS 8PXW 8PXX
Enriched GO Terms of Interacting Partners?		RNA Binding RNA Splicing MRNA Processing MRNA Metabolic Process RNA Processing RNA Metabolic Process Nucleoplasm Spliceosomal Complex Assembly U2-type Precatalytic Spliceosome Nucleus MRNA Splicing, Via Spliceosome Nuclear Speck Protein-RNA Complex Assembly RNA Splicing, Via Transesterification Reactions Nucleic Acid Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome U2-type Prespliceosome Nucleobase-containing Compound Metabolic Process U1 SnRNP Precatalytic Spliceosome Nuclear Matrix Regulation Of MRNA Processing Positive Regulation Of Viral Genome Replication 14-3-3 Protein Binding Spliceosomal Complex Regulation Of RNA Splicing Negative Regulation Of Viral Genome Replication Positive Regulation Of Viral Process Macromolecule Metabolic Process Negative Regulation Of Viral Process Regulation Of Viral Genome Replication Regulation Of MRNA Metabolic Process Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Mitotic Checkpoint Complex Meiotic Sister Chromatid Cohesion, Centromeric Regulation Of Viral Life Cycle Nuclear Speck Organization THO Complex SnRNA Catabolic Process Regulation Of Viral Process THO Complex Part Of Transcription Export Complex Protein Kinase Activity Metaphase/anaphase Transition Of Mitotic Cell Cycle Metaphase/anaphase Transition Of Cell Cycle R-loop Processing Meiotic Sister Chromatid Cohesion Kinase Activity Transcription Export Complex SnRNA Binding	RNA Splicing MRNA Processing MRNA Metabolic Process RNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Binding Nuclear Speck Nucleic Acid Binding Spliceosomal Complex Nucleoplasm Nucleus Spliceosomal Complex Assembly RNA Metabolic Process U2 SnRNP Catalytic Step 2 Spliceosome Nucleic Acid Metabolic Process U2-type Prespliceosome Assembly Actin Binding U2-type Precatalytic Spliceosome Profilin Binding SCAR Complex Cellular Component Assembly Actin Polymerization Or Depolymerization Regulation Of RNA Splicing Nucleobase-containing Compound Metabolic Process Ribonucleoprotein Complex MRNA 3'-splice Site Recognition Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Protein-RNA Complex Assembly Actin Filament-based Process Positive Regulation Of Protein Localization To Cajal Body Positive Regulation Of Metabolic Process Protein Binding Alternative MRNA Splicing, Via Spliceosome U12-type Spliceosomal Complex Regulation Of Macromolecule Metabolic Process PML Body SUMO Ligase Activity Cytosol U2-type Spliceosomal Complex Positive Regulation Of Macromolecule Metabolic Process Actin Cytoskeleton Organization Focal Adhesion Regulation Of Metabolic Process U2-type Prespliceosome CRD-mediated MRNA Stability Complex
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