DHX8

Description		DEAH-box helicase 8
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cytosol Nuclear Body U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome Ribonucleoprotein Complex
	Molecular Function	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Helicase Activity Protein Binding ATP Binding ATP-dependent Activity, Acting On RNA Hydrolase Activity ATP Hydrolysis Activity Identical Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome RNA Processing MRNA Processing RNA Splicing
Pathways		mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535)
Interacting Genes		12 interacting genes: BUB1B LUC7L2 MFAP1 PRPF38A PRPF40A RBM7 RBMX2 SAP30BP SRPK1 SRPK2 THOC1 UBC
Entrez ID		1659
HPRD ID		02672
Ensembl ID		ENSG00000067596
Uniprot IDs		B7Z8F4 F5H658 K7END7 Q05CV4 Q14562 Q86YB2
PDB IDs		2EQS 3I4U 5MQF 5XJC 6HYS 6HYT 6HYU 6ICZ 6QDV 7W59 7W5A 7W5B 8C6J 9FMD
Enriched GO Terms of Interacting Partners?		RNA Binding RNA Splicing MRNA Processing MRNA Metabolic Process RNA Processing RNA Metabolic Process Nucleoplasm Spliceosomal Complex Assembly U2-type Precatalytic Spliceosome Nucleus MRNA Splicing, Via Spliceosome Nuclear Speck Protein-RNA Complex Assembly RNA Splicing, Via Transesterification Reactions Nucleic Acid Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome U2-type Prespliceosome Nucleobase-containing Compound Metabolic Process U1 SnRNP Precatalytic Spliceosome Nuclear Matrix Regulation Of MRNA Processing Positive Regulation Of Viral Genome Replication 14-3-3 Protein Binding Spliceosomal Complex Regulation Of RNA Splicing Negative Regulation Of Viral Genome Replication Positive Regulation Of Viral Process Macromolecule Metabolic Process Negative Regulation Of Viral Process Regulation Of Viral Genome Replication Regulation Of MRNA Metabolic Process Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Mitotic Checkpoint Complex Meiotic Sister Chromatid Cohesion, Centromeric Regulation Of Viral Life Cycle Nuclear Speck Organization THO Complex SnRNA Catabolic Process Regulation Of Viral Process THO Complex Part Of Transcription Export Complex Protein Kinase Activity Metaphase/anaphase Transition Of Mitotic Cell Cycle Metaphase/anaphase Transition Of Cell Cycle R-loop Processing Meiotic Sister Chromatid Cohesion Kinase Activity Transcription Export Complex SnRNA Binding
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