HSD17B14 and MIA3

Number of citations: 72 (PubMedID 27107012)
Data Source: BioGRID (two hybrid)

		HSD17B14	MIA3
Name		hydroxysteroid 17-beta dehydrogenase 14	MIA SH3 domain ER export factor 3
Structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Membrane Endoplasmic Reticulum Exit Site
	Molecular Function	Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity Protein Binding Oxidoreductase Activity Identical Protein Binding D-threo-aldose 1-dehydrogenase Activity	Protein Binding Cargo Receptor Activity
	Biological Process	Fucose Metabolic Process Lipid Metabolic Process Steroid Metabolic Process L-fucose Catabolic Process	Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Leukocyte Migration Exocytosis Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Endoplasmic Reticulum Organization Negative Regulation Of Cell Adhesion Protein Secretion Protein Transport Vesicle-mediated Transport Negative Regulation Of Cell Migration Vesicle Cargo Loading Wound Healing Lipoprotein Transport System Development Protein Localization To Endoplasmic Reticulum Exit Site COPII-coated Vesicle Cargo Loading Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus Negative Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Lymphocyte Migration
Pathways		Estrogen biosynthesis	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Cargo concentration in the ER Post-translational protein phosphorylation
GWAS		Blood protein levels ( 30072576 ) Resting metabolic rate ( 28476931 )	Coronary artery disease ( 26343387 29212778 32469254 33020668 ) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975 ) Coronary heart disease ( 17634449 21378990 ) Myocardial infarction ( 26343387 33532862 ) Myocardial infarction (early onset) ( 19198609 )
Interacting Genes		24 interacting genes: AKIRIN2 BRIP1 CA8 CDKN2D CYTOR DDIT3 INCA1 MIA3 MIR4435-2HG MPG NEK6 NTAQ1 NUDT18 OTUD3 PGLYRP3 PHF1 PICK1 PIDD1 PSMA1 REL SNAPC3 SNRPC SREK1IP1 TBC1D22B	17 interacting genes: CACNA1A CEP55 CLIC3 COL7A1 FXR2 HOMER3 HSD17B14 ITGAX LENG8 MTNR1B NCK2 PRDM14 SEC16A SEC23A SEC24C TRIM27 UBC
Entrez ID		51171	375056
HPRD ID		16801	18918
Ensembl ID		ENSG00000087076	ENSG00000154305
Uniprot IDs		A0A140VJH8 Q9BPX1	Q5JRA6
PDB IDs		1YDE 5EN4 5HS6 5ICM 5ICS 5JS6 5JSF 5L7T 5L7W 5L7Y 5O42 5O43 5O6O 5O6X 5O6Z 5O72 5O7C 6EMM 6FFB 6G4L 6GBT 6GTB 6GTU 6H0M 6HNO 6QCK 6ZDE 6ZDI 6ZR6 6ZRA 6ZT2	5KYN 5KYU 5KYW 7R3M
GO Terms Enriched among Interactors		None	Endoplasmic Reticulum Exit Site ER To Golgi Transport Vesicle Membrane COPII Vesicle Coat COPII-coated Vesicle Cargo Loading Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Vesicle Cargo Loading