HSD17B14 and AKIRIN2

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		HSD17B14	AKIRIN2
Name		hydroxysteroid 17-beta dehydrogenase 14	akirin 2
Structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Chromatin Nucleus Nucleoplasm Cytoplasm Membrane Transcription Repressor Complex
	Molecular Function	Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity Protein Binding Oxidoreductase Activity Identical Protein Binding D-threo-aldose 1-dehydrogenase Activity	Transcription Coregulator Activity Protein Binding Enzyme Binding Protein-macromolecule Adaptor Activity Identical Protein Binding
	Biological Process	Fucose Metabolic Process Lipid Metabolic Process Steroid Metabolic Process L-fucose Catabolic Process	Adaptive Immune Response Immune System Process Positive Regulation Of Adaptive Immune Response Protein Import Into Nucleus Embryo Development Ending In Birth Or Egg Hatching Proteasomal Protein Catabolic Process Protein Transport Cerebral Cortex Development Proteasome Localization Response To Lipopolysaccharide Positive Regulation Of Interleukin-6 Production Defense Response To Bacterium Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of B Cell Activation Regulation Of Muscle Cell Differentiation Nuclear Protein Quality Control By The Ubiquitin-proteasome System
Pathways		Estrogen biosynthesis	None
GWAS		Blood protein levels ( 30072576 ) Resting metabolic rate ( 28476931 )	No GWAS studies recorded
Interacting Genes		24 interacting genes: AKIRIN2 BRIP1 CA8 CDKN2D CYTOR DDIT3 INCA1 MIA3 MIR4435-2HG MPG NEK6 NTAQ1 NUDT18 OTUD3 PGLYRP3 PHF1 PICK1 PIDD1 PSMA1 REL SNAPC3 SNRPC SREK1IP1 TBC1D22B	11 interacting genes: CCDC85B FBXO7 HNRNPF HSD17B14 LNX1 MESD MYOZ3 NTAQ1 SORBS3 SPG21 UBR5
Entrez ID		51171	55122
HPRD ID		16801	12864
Ensembl ID		ENSG00000087076	ENSG00000135334
Uniprot IDs		A0A140VJH8 Q9BPX1	Q53H80 Q9NW35
PDB IDs		1YDE 5EN4 5HS6 5ICM 5ICS 5JS6 5JSF 5L7T 5L7W 5L7Y 5O42 5O43 5O6O 5O6X 5O6Z 5O72 5O7C 6EMM 6FFB 6G4L 6GBT 6GTB 6GTU 6H0M 6HNO 6QCK 6ZDE 6ZDI 6ZR6 6ZRA 6ZT2	7NHT
GO Terms Enriched among Interactors		None	Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Ubiquitin-protein Transferase Activity Lewy Neurite D-threo-aldose 1-dehydrogenase Activity Protein-N-terminal Glutamine Amidohydrolase Activity