TSPAN15 and BTRC

Number of citations of the paper that reports this interaction (PMID 12037680)
8

Data Source:
HPRD (in vivo, in vitro)

		TSPAN15	BTRC
Gene Name		tetraspanin 15	beta-transducin repeat containing E3 ubiquitin protein ligase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Cell Surface Integral Component Of Membrane Extracellular Vesicular Exosome Tetraspanin-enriched Microdomain	Nucleoplasm Cytosol SCF Ubiquitin Ligase Complex
	Molecular Function	Enzyme Binding	Ubiquitin-protein Transferase Activity Protein Binding Beta-catenin Binding Ligase Activity Protein Phosphorylated Amino Acid Binding Protein Dimerization Activity
	Biological Process	Regulation Of Notch Signaling Pathway Protein Maturation Establishment Of Protein Localization To Plasma Membrane	G2/M Transition Of Mitotic Cell Cycle Protein Polyubiquitination Mitotic Cell Cycle Protein Dephosphorylation Ubiquitin-dependent Protein Catabolic Process Signal Transduction Circadian Rhythm Viral Process Wnt Signaling Pathway Protein Ubiquitination Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Destabilization Mammary Gland Epithelial Cell Proliferation Regulation Of Circadian Rhythm Positive Regulation Of Circadian Rhythm Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Proteolysis Negative Regulation Of Smoothened Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Cell Cycle Branching Involved In Mammary Gland Duct Morphogenesis Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Organic Cyclic Compound
Pathways			Signaling by the B Cell Receptor (BCR) Hedgehog 'off' state misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated TCF7L2 mutants don't bind CTBP truncated APC mutants destabilize the destruction complex Signaling by Wnt Regulation of PLK1 Activity at G2/M Transition Downstream signaling events of B Cell Receptor (BCR) Degradation of beta-catenin by the destruction complex AXIN mutants destabilize the destruction complex, activating WNT signaling S33 mutants of beta-catenin aren't phosphorylated RNF mutants show enhanced WNT signaling and proliferation Prolactin receptor signaling truncations of AMER1 destabilize the destruction complex misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex Host Interactions of HIV factors AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated Regulation of APC/C activators between G1/S and early anaphase Signaling by ERBB4 APC/C-mediated degradation of cell cycle proteins Signaling by Interleukins deletions in the AMER1 gene destabilize the destruction complex AMER1 mutants destabilize the destruction complex Interleukin-1 signaling Mitotic G2-G2/M phases Adaptive Immune System Antigen processing: Ubiquitination & Proteasome degradation APC truncation mutants have impaired AXIN binding HIV Infection G2/M Transition deactivation of the beta-catenin transactivating complex APC truncation mutants are not K63 polyubiquitinated S37 mutants of beta-catenin aren't phosphorylated XAV939 inhibits tankyrase, stabilizing AXIN Class I MHC mediated antigen processing & presentation Vpu mediated degradation of CD4 Cytokine Signaling in Immune system Cell Cycle, Mitotic Nuclear signaling by ERBB4 TCF dependent signaling in response to WNT Activation of NF-kappaB in B cells SCF-beta-TrCP mediated degradation of Emi1 Regulation of mitotic cell cycle deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by Hedgehog Degradation of GLI1 by the proteasome Signaling by WNT in cancer GLI3 is processed to GLI3R by the proteasome Degradation of GLI2 by the proteasome
Drugs
Diseases
GWAS		Response to taxane treatment (placlitaxel) ( 23006423)
Protein-Protein Interactions		3 interactors: BTRC RGS2 SYNE4	72 interactors: AGO2 AMER1 ATF4 AXIN1 BHLHE40 BORA CCND1 CCNE1 CDC25A CDC34 CDK1 CHPF CHUK CP CTNNB1 CUL1 DBN1 DEPTOR DLGAP5 E2F1 FBXO5 FBXW11 FOXO3 GH1 GHR GLI3 GSK3B HIPK2 HNRNPC HNRNPK HNRNPU ICE1 JUP KDR MDM2 MYB MYC NFE2 NFKB1 NFKB2 NFKBIA NFKBIB PCDH8 PDCD4 PRDX1 PSMA3 PSMD4 RASSF5 RCAN1 RELA SKP1 SMAD3 SMAD4 SMURF2 SP1 SUFU TACC1 TAZ TFAP4 TIAM1 TP63 TRIM9 TSPAN15 UBE2D2 UBE2D3 UBE2R2 UBQLN2 UHRF1 USP37 WEE1 YAP1 ZC3H12A
Entrez ID		23555	8945
HPRD ID		15511	04596
Ensembl ID		ENSG00000099282	ENSG00000166167
Uniprot IDs		O95858	B2R8L3 B7Z3H4 Q68DS0 Q9Y297
PDB IDs			1P22 2P64
Enriched GO Terms of Interacting Partners?		Establishment Of Epithelial Cell Apical/basal Polarity Regulation Of Adrenergic Receptor Signaling Pathway Positive Regulation Of Cardiac Muscle Contraction Negative Regulation Of CAMP-mediated Signaling Establishment Of Apical/basal Cell Polarity Negative Regulation Of Phospholipase Activity Polarized Epithelial Cell Differentiation Posttranscriptional Regulation Of Gene Expression Relaxation Of Vascular Smooth Muscle Negative Regulation Of Cardiac Muscle Hypertrophy Relaxation Of Smooth Muscle Establishment Of Monopolar Cell Polarity Negative Regulation Of Muscle Hypertrophy Positive Regulation Of Striated Muscle Contraction Morphogenesis Of An Epithelium Positive Regulation Of Microtubule Polymerization Relaxation Of Cardiac Muscle Negative Regulation Of Smooth Muscle Contraction Establishment Of Epithelial Cell Polarity Tissue Morphogenesis Positive Regulation Of Circadian Rhythm Negative Regulation Of Lipase Activity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Mammary Gland Epithelial Cell Proliferation Negative Regulation Of Muscle Contraction Regulation Of CAMP-mediated Signaling Relaxation Of Muscle Morphogenesis Of A Polarized Epithelium SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Destabilization Establishment Or Maintenance Of Apical/basal Cell Polarity Positive Regulation Of Heart Contraction Regulation Of Microtubule Polymerization Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Smoothened Signaling Pathway Vasodilation Brown Fat Cell Differentiation Epithelium Development Branching Involved In Mammary Gland Duct Morphogenesis Negative Regulation Of Signal Transduction Regulation Of Smooth Muscle Contraction Negative Regulation Of Signaling Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Mammary Gland Duct Morphogenesis Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Microtubule Polymerization Or Depolymerization	Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Response To Growth Factor Cell Communication G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Negative Regulation Of Cellular Metabolic Process Regulation Of Signal Transduction Signaling Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Cellular Response To Organic Substance Cellular Response To Growth Factor Stimulus Negative Regulation Of Transcription, DNA-templated Intracellular Signal Transduction Response To Organic Substance Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Apoptotic Process Regulation Of Signaling Programmed Cell Death Regulation Of Transcription, DNA-templated Cell Death Death Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Signal Transduction Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Canonical Wnt Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Signal Transduction Cellular Response To Stimulus Cell Cycle Process Regulation Of Wnt Signaling Pathway Regulation Of Protein Localization To Nucleus
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