TSPAN15 and GYPC

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		TSPAN15	GYPC
Name		tetraspanin 15	glycophorin C (Gerbich blood group)
Structure
GO Annotations	Cellular Component	Endosome Endoplasmic Reticulum Lumen Cytosol Plasma Membrane Cell Surface Membrane Nuclear Body Cell Junction Late Endosome Membrane Tetraspanin-enriched Microdomain	Plasma Membrane Membrane Cortical Cytoskeleton
	Molecular Function	Protein Binding Enzyme Binding	Protein Binding
	Biological Process	Regulation Of Notch Signaling Pathway Negative Regulation Of Notch Signaling Pathway Regulation Of Membrane Protein Ectodomain Proteolysis Protein Maturation Protein Localization To Plasma Membrane	None
Pathways		Amyloid fiber formation	Cell surface interactions at the vascular wall
GWAS		Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Height ( 31562340 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Immature fraction of reticulocytes ( 32888494 ) Response to taxane treatment (paclitaxel) ( 23006423 ) Reticulocyte count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 ) Thrombosis ( 26908601 ) Type 2 diabetes ( 32499647 ) Venous thromboembolism ( 25772935 28373160 31420334 31676865 )	Atrial fibrillation ( 29892015 30061737 ) Diastolic blood pressure ( 30224653 ) Hemoglobin levels ( 32327693 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Initial pursuit acceleration ( 29064472 ) Intelligence ( 22449649 ) Metabolite levels ( 23823483 ) Pelvic organ prolapse (moderate/severe) ( 26545240 ) Pyoderma gangrenosum in inflammatory bowel disease ( 24487271 ) Reticulocyte count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 ) Systolic blood pressure ( 31217584 ) Tea consumption ( 31046077 )
Novel Interactors		9 novel interactors: ADAMDEC1 CHI3L1 KLRC3 RUFY2 SERBP1 SETDB1 SLC25A16 TCHP TSPO	None recorded
Interacting Genes		5 interacting genes: BTRC GYPC RGS2 STRIT1 SYNE4	13 interacting genes: ABHD16A AQP6 EPB41 GPR42 MPP1 PDIA3 PLPPR2 RHBDD1 SHISAL1 SLC10A6 TMEM14B TMEM88 TSPAN15
Entrez ID		23555	2995
HPRD ID		15511	00193
Ensembl ID		ENSG00000099282	ENSG00000136732
Uniprot IDs		O95858	P04921
PDB IDs		7RD5 7RDB 8ESV	2EJY
GO Terms Enriched among Interactors		None	PH-gated Chloride Channel Activity Nitrate Transmembrane Transporter Activity Nitrate Transmembrane Transport Membrane Cortical Cytoskeleton Tapasin-ERp57 Complex Phosphatidylserine Catabolic Process Prostaglandin Catabolic Process Membrane Protein Proteolysis Involved In Retrograde Protein Transport, ER To Cytosol Sodium-dependent Organic Anion Transmembrane Transporter Activity Sodium-dependent Organic Anion Transport