DAXX and TSG101

Number of citations of the paper that reports this interaction (PubMedID 15033475)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, two hybrid)

		DAXX	TSG101
Description		death domain associated protein	tumor susceptibility 101
Image
GO Annotations	Cellular Component	Chromosome, Centromeric Region Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Cytosol Nuclear Body PML Body	ESCRT I Complex Nucleus Nucleolus Cytoplasm Endosome Early Endosome Late Endosome Multivesicular Body Centrosome Cytosol Cytoskeleton Plasma Membrane Endosome Membrane Membrane Early Endosome Membrane Late Endosome Membrane Extracellular Exosome Flemming Body
	Molecular Function	P53 Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Enzyme Binding Protein Kinase Binding Protein Kinase Activator Activity Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Histone Binding Protein Homodimerization Activity Nuclear Androgen Receptor Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Regulator Inhibitor Activity Molecular Condensate Scaffold Activity	DNA Binding Transcription Corepressor Activity Protein Binding Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Ubiquitin Binding Protein-containing Complex Binding Virion Binding Calcium-dependent Protein Binding
	Biological Process	Chromatin Organization Nucleosome Assembly Chromatin Remodeling Regulation Of DNA-templated Transcription Apoptotic Process JNK Cascade Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Gene Expression Negative Regulation Of Gene Expression Androgen Receptor Signaling Pathway Regulation Of Protein Ubiquitination Cellular Response To Heat Cellular Response To Unfolded Protein Neuron Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Regulation Of Apoptotic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Cellular Response To Cadmium Ion Cellular Response To Copper Ion Cellular Response To Diamide Cellular Response To Sodium Arsenite	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Growth Extracellular Transport Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Cell Population Proliferation Endosome To Lysosome Transport Protein Transport Macroautophagy Viral Release From Host Cell Cell Differentiation Keratinocyte Differentiation Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of MAP Kinase Activity Viral Budding Cell Division Regulation Of Cell Cycle Membrane Fission Autophagosome Maturation Positive Regulation Of Exosomal Secretion Regulation Of Extracellular Exosome Assembly Positive Regulation Of Viral Budding Via Host ESCRT Complex Exosomal Secretion Positive Regulation Of Ubiquitin-dependent Endocytosis
Pathways		SUMOylation of transcription cofactors Regulation of TP53 Degradation HCMV Early Events Inhibition of DNA recombination at telomere Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	Budding and maturation of HIV virion Membrane binding and targetting of GAG proteins Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy
Drugs
Diseases
GWAS		Adult body size ( 32376654) Autism spectrum disorder or schizophrenia ( 28540026) Disrupted circadian rhythm (low relative amplitude of rest-activity cycles) ( 30120083) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730)
Interacting Genes		114 interacting genes: ACVR2A AIRE AMOTL2 AR ATM ATRX BTBD6 CA12 CALCOCO2 CARD9 CARM1 CBS CDCA7L CENPC CEP63 CEP70 CFLAR CREBBP CSNK2A1 CSNK2B DAPK3 DKC1 DMAP1 DNMT1 DRC4 ESRRG ETS1 FAM9B FANCA FAS FASLG FTH1 GOLGA2 GOLGA6L9 GRIPAP1 H3-3B H3-5 H3C3 H4C16 HABP4 HBA1 HDAC1 HDAC2 HDAC3 HIPK1 HIPK2 HIPK3 HSF1 HSF4 HSPB1 KCTD4 MAP3K5 MCRS1 MDM2 MEN1 MIPOL1 MKRN1 MSANTD4 MX1 MYH11 NECAB2 NSD3 PARK7 PAX3 PAX5 PBXIP1 PIBF1 PLAGL1 PML PNMA1 PRMT1 PTEN RASSF1 RASSF3 RIPK3 RNF4 RPL13 SENP2 SERBP1 SLC2A4 SLC9A1 SNW1 SPN SPOP SQSTM1 SSX2IP STAT3 STK4 STUB1 SUMO1 SUMO2 SUMO3 TAX1BP1 TCF3 TCF4 TCF7L2 TFIP11 TGFB1 TGFBR2 TNFRSF1A TP53 TP63 TP73 TRAF3 TRIM21 TRIM54 TSG101 UBC UBE2I USH1G USP7 WEE2-AS1 ZBTB2 ZBTB26	136 interacting genes: AATF ADRB2 AJUBA AKAP9 AR BAG4 BCAS3 BCR BIRC2 CAGE1 CBY1 CCDC88B CCHCR1 CCND3 CDKN1A CDKN2D CDS2 CEP55 CEP63 CHD7 CNOT7 DAXX DMAP1 DMRTB1 DNMT1 DSCR9 DZIP3 EP300 FAM110A FAM9B GGA1 GGA3 GLI2 GLIS3 GMCL1 GOLM1 GPRC5B GUCY1B2 HAUS1 HCK HGS HSH2D INCA1 IQGAP1 IRF2BPL ITPRID2 ITSN1 JUN KIAA1328 KIF5A KIFC3 KLK5 KLK6 KRT13 KRT15 KRT16 KRT18 KRT31 KRT34 KRT35 KRT75 LCN2 LENG8 LNX1 LRRFIP1 LRSAM1 MDM2 MGRN1 MKRN3 MTA3 MZB1 NR3C1 NUP214 OGT PDCD6IP PDLIM7 PIAS1 PIP4P2 PKNOX2 PPFIBP2 PPP1R13B PRDM16 PRRC1 PRSS50 QKI RAD18 RASL10B RBPMS RNF111 RNF126 RNF41 ROCK1 SCAMP3 SCARA5 SCGB3A1 SCNN1A SH3GLB2 SHANK3 SNAPIN SNCA SNF8 SNX32 STK11 SYCE1 TAX1BP1 TEX11 TFF1 TFIP11 THRB THRSP TNF TNIP2 TNNT3 TOM1L1 TP53 TRAIP TRIM23 TRIM35 TRIM46 TRIM54 TRIM74 TRIML2 UBA52 UBC USF3 USHBP1 VPS11 VPS28 VPS36 VPS37A VPS37B VPS37C VPS37D WASHC1 YLPM1 ZWINT
Entrez ID		1616	7251
HPRD ID		04424	03229
Ensembl ID		ENSG00000204209	ENSG00000074319
Uniprot IDs		A0A024RCS3 B4E1C1 Q53F85 Q9UER7	Q99816
PDB IDs		2KQS 2KZS 2KZU 4H9N 4H9O 4H9P 4H9Q 4H9R 4H9S 4HGA 5GRQ 5KDM 5Y18 5Y6O	1KPP 1KPQ 1M4P 1M4Q 1S1Q 2F0R 3IV1 3OBQ 3OBS 3OBU 3OBX 3P9G 3P9H 4EJE 4YC1 4ZNY 5VKG 6UD0 6VME 7NLC 7ZLX
Enriched GO Terms of Interacting Partners?		PML Body Identical Protein Binding Nucleus Nucleoplasm Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Stress Positive Regulation Of Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA Damage Response Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Programmed Cell Death Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Apoptotic Signaling Pathway Regulation Of Signal Transduction Regulation Of Macromolecule Biosynthetic Process Regulation Of Apoptotic Process Regulation Of Protein Metabolic Process PML Body Organization Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Transcription By RNA Polymerase II Nuclear Body Regulation Of Gene Expression Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Intracellular Signal Transduction Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Regulation Of Signaling Positive Regulation Of Programmed Cell Death Regulation Of Cell Communication Positive Regulation Of Intracellular Signal Transduction Programmed Cell Death	Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Multivesicular Body Organization Multivesicular Body Assembly Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Endosome Transport Via Multivesicular Body Sorting Pathway Vacuolar Transport Ubiquitin Protein Ligase Activity Multivesicular Body Sorting Pathway Autophagy Cytosol Late Endosome To Vacuole Transport Viral Budding Endosome Organization Establishment Of Protein Localization To Vacuole Intracellular Protein Localization Membrane Fission Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein Localization To Vacuole Organelle Organization ESCRT I Complex Viral Budding Via Host ESCRT Complex Programmed Cell Death Cell Death Endosomal Transport Intracellular Protein Transport Macroautophagy Zinc Ion Binding Protein Ubiquitination Protein Transport Vesicle-mediated Transport Protein Modification By Small Protein Conjugation Apoptotic Process Establishment Of Protein Localization Cellular Localization Cytoplasm Cytoskeleton Structural Constituent Of Skin Epidermis Endosome Membrane Protein Binding Intracellular Transport Protein Localization To Organelle Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Ubiquitin Binding Intermediate Filament Organization Positive Regulation Of Catabolic Process Regulation Of Protein Metabolic Process Viral Process Post-translational Protein Modification
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