DAXX and MEN1

Number of citations of the paper that reports this interaction (PubMedID 27872097)
42

Data Source:
BioGRID (affinity chromatography technology, pull down)

		DAXX	MEN1
Description		death domain associated protein	menin 1
Image
GO Annotations	Cellular Component	Chromosome, Centromeric Region Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Cytosol Nuclear Body PML Body	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Lumen Cytosol Nuclear Matrix Transcription Repressor Complex Cleavage Furrow Protein-containing Complex Histone Methyltransferase Complex MLL1/2 Complex MLL1 Complex
	Molecular Function	P53 Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Enzyme Binding Protein Kinase Binding Protein Kinase Activator Activity Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Histone Binding Protein Homodimerization Activity Nuclear Androgen Receptor Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Regulator Inhibitor Activity Molecular Condensate Scaffold Activity	Four-way Junction DNA Binding Y-form DNA Binding Transcription Cis-regulatory Region Binding DNA Binding Chromatin Binding Double-stranded DNA Binding Protein Binding Protein-macromolecule Adaptor Activity Phosphoprotein Binding R-SMAD Binding
	Biological Process	Chromatin Organization Nucleosome Assembly Chromatin Remodeling Regulation Of DNA-templated Transcription Apoptotic Process JNK Cascade Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Gene Expression Negative Regulation Of Gene Expression Androgen Receptor Signaling Pathway Regulation Of Protein Ubiquitination Cellular Response To Heat Cellular Response To Unfolded Protein Neuron Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Regulation Of Apoptotic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Cellular Response To Cadmium Ion Cellular Response To Copper Ion Cellular Response To Diamide Cellular Response To Sodium Arsenite	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Negative Regulation Of Protein Phosphorylation Osteoblast Development DNA Repair Chromatin Organization Regulation Of Transcription By RNA Polymerase II DNA Damage Response Negative Regulation Of Cell Population Proliferation Response To UV Response To Gamma Radiation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of DNA-binding Transcription Factor Activity T-helper 2 Cell Differentiation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Cycle Transcription Initiation-coupled Chromatin Remodeling Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of JNK Cascade
Pathways		SUMOylation of transcription cofactors Regulation of TP53 Degradation HCMV Early Events Inhibition of DNA recombination at telomere Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	Formation of the beta-catenin:TCF transactivating complex SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Deactivation of the beta-catenin transactivating complex Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) RHO GTPases activate IQGAPs Post-translational protein phosphorylation Formation of WDR5-containing histone-modifying complexes
Drugs
Diseases			Primary hyperparathyroidism; Familial hyperparathyroidism (HRPT) Adrenal carcinoma Malignant islet cell carcinoma Carcinoid
GWAS		Adult body size ( 32376654) Autism spectrum disorder or schizophrenia ( 28540026) Disrupted circadian rhythm (low relative amplitude of rest-activity cycles) ( 30120083) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730)	Urate levels ( 21768215)
Interacting Genes		114 interacting genes: ACVR2A AIRE AMOTL2 AR ATM ATRX BTBD6 CA12 CALCOCO2 CARD9 CARM1 CBS CDCA7L CENPC CEP63 CEP70 CFLAR CREBBP CSNK2A1 CSNK2B DAPK3 DKC1 DMAP1 DNMT1 DRC4 ESRRG ETS1 FAM9B FANCA FAS FASLG FTH1 GOLGA2 GOLGA6L9 GRIPAP1 H3-3B H3-5 H3C3 H4C16 HABP4 HBA1 HDAC1 HDAC2 HDAC3 HIPK1 HIPK2 HIPK3 HSF1 HSF4 HSPB1 KCTD4 MAP3K5 MCRS1 MDM2 MEN1 MIPOL1 MKRN1 MSANTD4 MX1 MYH11 NECAB2 NSD3 PARK7 PAX3 PAX5 PBXIP1 PIBF1 PLAGL1 PML PNMA1 PRMT1 PTEN RASSF1 RASSF3 RIPK3 RNF4 RPL13 SENP2 SERBP1 SLC2A4 SLC9A1 SNW1 SPN SPOP SQSTM1 SSX2IP STAT3 STK4 STUB1 SUMO1 SUMO2 SUMO3 TAX1BP1 TCF3 TCF4 TCF7L2 TFIP11 TGFB1 TGFBR2 TNFRSF1A TP53 TP63 TP73 TRAF3 TRIM21 TRIM54 TSG101 UBC UBE2I USH1G USP7 WEE2-AS1 ZBTB2 ZBTB26	31 interacting genes: ANXA1 ASH2L CTNNB1 DAXX DBF4 ESR1 FANCD2 FOXN3 GFAP H3-4 IQGAP1 JUND KMT2A KMT2D MYC MYH9 NFKB1 NFKB2 POLR2B RBBP5 RELA RPA2 SIN3A SMAD1 SMAD3 SMAD5 SNW1 TCF3 TCF7L2 TP53 VIM
Entrez ID		1616	4221
HPRD ID		04424	00564
Ensembl ID		ENSG00000204209	ENSG00000133895
Uniprot IDs		A0A024RCS3 B4E1C1 Q53F85 Q9UER7	A0A5F9ZHS3 A0AA75I0P0 E7EN32 O00255 Q9GZQ5
PDB IDs		2KQS 2KZS 2KZU 4H9N 4H9O 4H9P 4H9Q 4H9R 4H9S 4HGA 5GRQ 5KDM 5Y18 5Y6O	3U84 3U85 3U86 3U88 4GPQ 4GQ3 4GQ4 4GQ6 4I80 4OG3 4OG4 4OG5 4OG6 4OG7 4OG8 4X5Y 4X5Z 5DB0 5DB1 5DB2 5DB3 5DD9 5DDA 5DDB 5DDC 5DDD 5DDE 5DDF 6B41 6BXH 6BXY 6BY8 6E1A 6O5I 6OPJ 6PKC 6S2K 6WNH 7M4T 7O9T 7O9X 7O9Z 7OA9 7UJ4 8E90 8GPN 8IG0 8VA5 8VA6 9C92 9C93 9C94
Enriched GO Terms of Interacting Partners?		PML Body Identical Protein Binding Nucleus Nucleoplasm Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Stress Positive Regulation Of Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA Damage Response Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Programmed Cell Death Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Apoptotic Signaling Pathway Regulation Of Signal Transduction Regulation Of Macromolecule Biosynthetic Process Regulation Of Apoptotic Process Regulation Of Protein Metabolic Process PML Body Organization Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Transcription By RNA Polymerase II Nuclear Body Regulation Of Gene Expression Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Intracellular Signal Transduction Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Regulation Of Signaling Positive Regulation Of Programmed Cell Death Regulation Of Cell Communication Positive Regulation Of Intracellular Signal Transduction Programmed Cell Death	Transcription Regulator Complex Nucleoplasm Nucleus Positive Regulation Of Macromolecule Biosynthetic Process Chromatin Positive Regulation Of Biosynthetic Process DNA Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Metabolic Process Transcription Cis-regulatory Region Binding DNA-binding Transcription Factor Activity Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process Regulation Of Cell Differentiation Regulation Of Metabolic Process Regulation Of MiRNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Positive Regulation Of Cell Differentiation Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of MiRNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Developmental Process Ubiquitin Protein Ligase Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Response To Growth Factor Cellular Developmental Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of MiRNA Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Intracellular Signal Transduction Negative Regulation Of Nucleobase-containing Compound Metabolic Process I-SMAD Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Nuclear Receptor Binding Positive Regulation Of Developmental Process Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Enzyme Binding Cellular Response To Growth Factor Stimulus Negative Regulation Of Macromolecule Biosynthetic Process Transcription Coactivator Binding Regulation Of Cell Population Proliferation RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-templated Transcription
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