DAXX and TP63

Number of citations of the paper that reports this interaction (PubMedID 12954772)
49

Data Source:
HPRD (two hybrid)

		DAXX	TP63
Description		death domain associated protein	tumor protein p63
Image
GO Annotations	Cellular Component	Chromosome, Centromeric Region Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Cytosol Nuclear Body PML Body	Chromatin Nucleus Nucleoplasm Cytoplasm Dendrite Protein-containing Complex
	Molecular Function	P53 Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Enzyme Binding Protein Kinase Binding Protein Kinase Activator Activity Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Histone Binding Protein Homodimerization Activity Nuclear Androgen Receptor Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Regulator Inhibitor Activity Molecular Condensate Scaffold Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific P53 Binding DNA Binding Chromatin Binding Damaged DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Identical Protein Binding Sequence-specific DNA Binding Metal Ion Binding WW Domain Binding MDM2/MDM4 Family Protein Binding Promoter-specific Chromatin Binding
	Biological Process	Chromatin Organization Nucleosome Assembly Chromatin Remodeling Regulation Of DNA-templated Transcription Apoptotic Process JNK Cascade Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Gene Expression Negative Regulation Of Gene Expression Androgen Receptor Signaling Pathway Regulation Of Protein Ubiquitination Cellular Response To Heat Cellular Response To Unfolded Protein Neuron Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Regulation Of Apoptotic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Cellular Response To Cadmium Ion Cellular Response To Copper Ion Cellular Response To Diamide Cellular Response To Sodium Arsenite	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Establishment Of Planar Polarity Morphogenesis Of A Polarized Epithelium Hair Follicle Development Epithelial Cell Development Chromatin Remodeling Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II Apoptotic Process DNA Damage Response Notch Signaling Pathway Spermatogenesis Pattern Specification Process Ectoderm And Mesoderm Interaction Positive Regulation Of Cell Population Proliferation Determination Of Adult Lifespan Epidermis Development Animal Organ Morphogenesis Epidermal Cell Differentiation Proximal/distal Pattern Formation Epidermal Cell Division Regulation Of Epidermal Cell Division Positive Regulation Of Keratinocyte Proliferation Keratinocyte Differentiation Embryonic Limb Morphogenesis Prostate Gland Development Epithelial Cell Differentiation Polarized Epithelial Cell Differentiation Hair Follicle Morphogenesis Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Post-anal Tail Morphogenesis Odontogenesis Of Dentin-containing Tooth Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Apoptotic Process Skin Morphogenesis Keratinocyte Proliferation Positive Regulation Of Cell Differentiation Negative Regulation Of Keratinocyte Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Notch Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Sympathetic Nervous System Development Anatomical Structure Formation Involved In Morphogenesis Female Genitalia Morphogenesis Stem Cell Differentiation Protein Tetramerization Neuron Apoptotic Process Cloacal Septation Prostatic Bud Formation Squamous Basal Epithelial Stem Cell Differentiation Involved In Prostate Gland Acinus Development Establishment Of Skin Barrier Stem Cell Proliferation Cellular Senescence Skin Epidermis Development Positive Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Somatic Stem Cell Population Maintenance Cranial Skeletal System Development Positive Regulation Of Fibroblast Apoptotic Process Negative Regulation Of Mesoderm Development Positive Regulation Of Stem Cell Proliferation Negative Regulation Of Cellular Senescence Positive Regulation Of Apoptotic Signaling Pathway
Pathways		SUMOylation of transcription cofactors Regulation of TP53 Degradation HCMV Early Events Inhibition of DNA recombination at telomere Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	Activation of PUMA and translocation to mitochondria Pyroptosis TP53 Regulates Metabolic Genes TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain TP53 Regulates Transcription of Caspase Activators and Caspases TP53 Regulates Transcription of Death Receptors and Ligands Regulation of TP53 Activity through Association with Co-factors Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
Drugs
Diseases			Split-hand/foot malformation (SHFM) Limb-mammary syndrome Ectrodactyly-ectodermal dysplasia cleft-palate syndrome (EEC syndrome) ADULT syndrome Ankyloblepharon-ctodermal defects-cleft lip/palate (AEC) syndrome and Rapp-Hodgkin syndrome Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate
GWAS		Adult body size ( 32376654) Autism spectrum disorder or schizophrenia ( 28540026) Disrupted circadian rhythm (low relative amplitude of rest-activity cycles) ( 30120083) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730)	Acute lymphoblastic leukemia (childhood) ( 22076464) Bladder cancer ( 24163127 20972438) Brain imaging ( 20100581) Chlamydia trachomatis PorB antibody levels ( 33204752) Circulating leptin levels in high cardiovascular risk ( 31766143) Cutaneous squamous cell carcinoma ( 32041948) EGFR mutation-positive lung adenocarcinoma ( 27501781) Lung adenocarcinoma ( 20871597 28604730 22797724) Lung cancer ( 24880342 23143601 28604730 21725308) Lung cancer in never smokers ( 31009812) Metabolite levels ( 23823483) Non-small cell lung cancer ( 31326317) Pancreatic cancer ( 26098869 29422604) Postoperative stroke after cardiac surgery ( 30678657) Psoriasis ( 25903422) Psoriasis vulgaris ( 26626624) Serum CC16 levels ( 32839289) Squamous cell carcinoma ( 26829030) Systemic lupus erythematosus ( 28714469) Urinary bladder cancer ( 20348956 18794855)
Interacting Genes		114 interacting genes: ACVR2A AIRE AMOTL2 AR ATM ATRX BTBD6 CA12 CALCOCO2 CARD9 CARM1 CBS CDCA7L CENPC CEP63 CEP70 CFLAR CREBBP CSNK2A1 CSNK2B DAPK3 DKC1 DMAP1 DNMT1 DRC4 ESRRG ETS1 FAM9B FANCA FAS FASLG FTH1 GOLGA2 GOLGA6L9 GRIPAP1 H3-3B H3-5 H3C3 H4C16 HABP4 HBA1 HDAC1 HDAC2 HDAC3 HIPK1 HIPK2 HIPK3 HSF1 HSF4 HSPB1 KCTD4 MAP3K5 MCRS1 MDM2 MEN1 MIPOL1 MKRN1 MSANTD4 MX1 MYH11 NECAB2 NSD3 PARK7 PAX3 PAX5 PBXIP1 PIBF1 PLAGL1 PML PNMA1 PRMT1 PTEN RASSF1 RASSF3 RIPK3 RNF4 RPL13 SENP2 SERBP1 SLC2A4 SLC9A1 SNW1 SPN SPOP SQSTM1 SSX2IP STAT3 STK4 STUB1 SUMO1 SUMO2 SUMO3 TAX1BP1 TCF3 TCF4 TCF7L2 TFIP11 TGFB1 TGFBR2 TNFRSF1A TP53 TP63 TP73 TRAF3 TRIM21 TRIM54 TSG101 UBC UBE2I USH1G USP7 WEE2-AS1 ZBTB2 ZBTB26	43 interacting genes: BAG6 BTRC CCNC CDC20 CDKN2A COPS6 CSNK2A1 CSNK2A2 CSNK2B DAXX EMX1 EP300 GCGR GRB2 HIPK2 HNRNPAB HP HPX ITIH4 KAT2B MCRS1 MDM4 NEDD4 NIPSNAP3A ORM1 PELI1 PELI2 PIN1 PINX1 PML PPP1R13B PPP2R5A RACK1 RCHY1 SCAF4 SLC35A3 STUB1 TP53 TP73 UBASH3A UBE2I WT1 YAP1
Entrez ID		1616	8626
HPRD ID		04424	04469
Ensembl ID		ENSG00000204209	ENSG00000073282
Uniprot IDs		A0A024RCS3 B4E1C1 Q53F85 Q9UER7	A0A0S2Z4N5 A0A0S2Z4N6 A0A141PNN3 A0A141PNN4 B7Z8X6 C9D7D0 Q9H3D4
PDB IDs		2KQS 2KZS 2KZU 4H9N 4H9O 4H9P 4H9Q 4H9R 4H9S 4HGA 5GRQ 5KDM 5Y18 5Y6O	1RG6 2NB1 2RMN 2Y9T 2Y9U 3QYM 3QYN 3US0 3US1 3US2 3ZY0 3ZY1 4A9Z 6FGN 6RU6 6RU7 6RU8 7Z71 7Z72 7Z73 7Z7E 8P9C 8P9D 8P9E 9GFO
Enriched GO Terms of Interacting Partners?		PML Body Identical Protein Binding Nucleus Nucleoplasm Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Stress Positive Regulation Of Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA Damage Response Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Programmed Cell Death Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Apoptotic Signaling Pathway Regulation Of Signal Transduction Regulation Of Macromolecule Biosynthetic Process Regulation Of Apoptotic Process Regulation Of Protein Metabolic Process PML Body Organization Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Transcription By RNA Polymerase II Nuclear Body Regulation Of Gene Expression Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Intracellular Signal Transduction Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Regulation Of Signaling Positive Regulation Of Programmed Cell Death Regulation Of Cell Communication Positive Regulation Of Intracellular Signal Transduction Programmed Cell Death	Regulation Of Protein Metabolic Process Negative Regulation Of Catabolic Process Regulation Of Metabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Nucleoplasm Regulation Of Macromolecule Metabolic Process Regulation Of Proteolysis Regulation Of Primary Metabolic Process Cellular Response To Stress DNA Damage Response Regulation Of Protein Catabolic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Macromolecule Metabolic Process Signal Transduction By P53 Class Mediator Positive Regulation Of Metabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Protein Modification Process Negative Regulation Of Metabolic Process P53 Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Protein Stability Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Cycle Negative Regulation Of Proteolysis Nucleus Regulation Of Cellular Response To Stress Apoptotic Signaling Pathway Protein Stabilization Protein Modification By Small Protein Conjugation Negative Regulation Of Nucleobase-containing Compound Metabolic Process PML Body Intrinsic Apoptotic Signaling Pathway Intracellular Signal Transduction Protein Kinase CK2 Complex Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Programmed Cell Death Regulation Of Protein Modification Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Stress Protein Metabolic Process Post-translational Protein Modification Macromolecule Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Post-translational Protein Modification Negative Regulation Of Programmed Cell Death Regulation Of Macromolecule Biosynthetic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?