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DAXX and FASLG
Number of citations of the paper that reports this interaction (PubMedID
9215629
)
44
Data Source:
HPRD
(in vivo, in vitro)
DAXX
FASLG
Description
death domain associated protein
Fas ligand
Image
GO Annotations
Cellular Component
Chromosome, Centromeric Region
Nucleus
Nucleoplasm
Chromosome
Nucleolus
Cytoplasm
Cytosol
Nuclear Body
PML Body
Extracellular Region
Extracellular Space
Nucleus
Cytoplasm
Lysosome
Plasma Membrane
Caveola
External Side Of Plasma Membrane
Cell Surface
Membrane
Cytoplasmic Vesicle
Lysosomal Lumen
Perinuclear Region Of Cytoplasm
Cytoplasmic Vesicle Lumen
Extracellular Exosome
Molecular Function
P53 Binding
Transcription Coactivator Activity
Transcription Corepressor Activity
Protein Binding
Enzyme Binding
Protein Kinase Binding
Protein Kinase Activator Activity
Heat Shock Protein Binding
Ubiquitin Protein Ligase Binding
Histone Binding
Protein Homodimerization Activity
Nuclear Androgen Receptor Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Transcription Regulator Inhibitor Activity
Molecular Condensate Scaffold Activity
Signaling Receptor Binding
Death Receptor Binding
Cytokine Activity
Tumor Necrosis Factor Receptor Binding
Protein Binding
Biological Process
Chromatin Organization
Nucleosome Assembly
Chromatin Remodeling
Regulation Of DNA-templated Transcription
Apoptotic Process
JNK Cascade
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Androgen Receptor Signaling Pathway
Regulation Of Protein Ubiquitination
Cellular Response To Heat
Cellular Response To Unfolded Protein
Neuron Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress
Regulation Of Apoptotic Process
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Cellular Response To Cadmium Ion
Cellular Response To Copper Ion
Cellular Response To Diamide
Cellular Response To Sodium Arsenite
Negative Regulation Of Transcription By RNA Polymerase II
Apoptotic Process
Inflammatory Cell Apoptotic Process
Immune Response
Signal Transduction
Cell-cell Signaling
Positive Regulation Of Cell Population Proliferation
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Negative Regulation Of Angiogenesis
Intracellular Chloride Ion Homeostasis
Response To Lipopolysaccharide
Positive Regulation Of Apoptotic Process
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Neuron Apoptotic Process
Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Retinal Cell Programmed Cell Death
Endosomal Lumen Acidification
T Cell Apoptotic Process
Necroptotic Process
Response To Growth Factor
Cellular Response To Type II Interferon
Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway
Necroptotic Signaling Pathway
Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum
Positive Regulation Of Phosphatidylserine Exposure On Apoptotic Cell Surface
Positive Regulation Of Endothelial Cell Apoptotic Process
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
SUMOylation of transcription cofactors
Regulation of TP53 Degradation
HCMV Early Events
Inhibition of DNA recombination at telomere
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations
Caspase activation via Death Receptors in the presence of ligand
Regulation by c-FLIP
RIPK1-mediated regulated necrosis
CASP8 activity is inhibited
Interleukin-4 and Interleukin-13 signaling
Dimerization of procaspase-8
FasL/ CD95L signaling
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
FOXO-mediated transcription of cell death genes
TNFs bind their physiological receptors
Drugs
Diseases
Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases: CD95 (Fas) defect, ALPS type 1a; CD95L (Fas ligand) defect, ALPS type 1b; Caspase 10 defect, ALPS type 2a; Caspase 8 defext, ALPS type 2b; Activaing N-Ras defect, N-Ras ALPS
GWAS
Adult body size (
32376654
)
Autism spectrum disorder or schizophrenia (
28540026
)
Disrupted circadian rhythm (low relative amplitude of rest-activity cycles) (
30120083
)
Lung cancer (
28604730
)
Lung cancer in ever smokers (
28604730
)
Allergic disease (asthma, hay fever and/or eczema) (age of onset) (
32603359
)
Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) (
32603359
)
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Allergic sensitization (
30013184
)
Asthma (
30929738
)
Asthma (childhood onset) (
30929738
)
Asthma onset (childhood vs adult) (
30929738
)
Autoimmune traits (pleiotropy) (
30572963
)
Celiac disease (
22057235
24999842
25920553
20190752
)
Crohn's disease (
21102463
23128233
)
Daytime sleep phenotypes (
27126917
)
Itch intensity from mosquito bite (
28199695
)
Psoriasis (
28537254
)
Systemic lupus erythematosus (
28714469
)
Type 1 diabetes (
34127860
)
Vitiligo (
27723757
)
Interacting Genes
114 interacting genes:
ACVR2A
AIRE
AMOTL2
AR
ATM
ATRX
BTBD6
CA12
CALCOCO2
CARD9
CARM1
CBS
CDCA7L
CENPC
CEP63
CEP70
CFLAR
CREBBP
CSNK2A1
CSNK2B
DAPK3
DKC1
DMAP1
DNMT1
DRC4
ESRRG
ETS1
FAM9B
FANCA
FAS
FASLG
FTH1
GOLGA2
GOLGA6L9
GRIPAP1
H3-3B
H3-5
H3C3
H4C16
HABP4
HBA1
HDAC1
HDAC2
HDAC3
HIPK1
HIPK2
HIPK3
HSF1
HSF4
HSPB1
KCTD4
MAP3K5
MCRS1
MDM2
MEN1
MIPOL1
MKRN1
MSANTD4
MX1
MYH11
NECAB2
NSD3
PARK7
PAX3
PAX5
PBXIP1
PIBF1
PLAGL1
PML
PNMA1
PRMT1
PTEN
RASSF1
RASSF3
RIPK3
RNF4
RPL13
SENP2
SERBP1
SLC2A4
SLC9A1
SNW1
SPN
SPOP
SQSTM1
SSX2IP
STAT3
STK4
STUB1
SUMO1
SUMO2
SUMO3
TAX1BP1
TCF3
TCF4
TCF7L2
TFIP11
TGFB1
TGFBR2
TNFRSF1A
TP53
TP63
TP73
TRAF3
TRIM21
TRIM54
TSG101
UBC
UBE2I
USH1G
USP7
WEE2-AS1
ZBTB2
ZBTB26
82 interacting genes:
APBB1
ARHGAP9
BAIAP2L1
BTK
CACNB3
CACNB4
CRK
CYSRT1
DAXX
DLG2
DMD
DNMBP
DOCK4
ECM1
EPS8L3
EZR
FADD
FAS
FGR
FN1
FNBP1
FYB1
FYN
GRAP
GRAP2
GRB2
HCK
IHO1
ITK
ITSN2
KALRN
KMT2A
KRT33B
KRT40
KRTAP11-1
KRTAP12-3
LCK
LYN
MACC1
MIA
MMP7
MPP4
MYO15A
NCF1
NCK1
NCK2
NCKIPSD
NOTCH2NLA
OSTF1
PACSIN2
PDCD6
PIK3CA
PIK3R1
PIN1
PPIAP11
PRPF40A
PSTPIP1
PTPN13
RGS20
RIMBP3C
SAMSN1
SEC23A
SH3GL3
SH3PXD2A
SH3PXD2B
SH3RF2
SKAP2
SNX33
SNX9
SORBS3
SPTA1
SRC
SRGAP1
SRGAP2
SRGAP3
SUMO1
TEC
TJP3
TNFRSF6B
TNS2
TRIP6
YES1
Entrez ID
1616
356
HPRD ID
04424
00610
Ensembl ID
ENSG00000204209
ENSG00000117560
Uniprot IDs
A0A024RCS3
B4E1C1
Q53F85
Q9UER7
P48023
Q53ZZ1
PDB IDs
2KQS
2KZS
2KZU
4H9N
4H9O
4H9P
4H9Q
4H9R
4H9S
4HGA
5GRQ
5KDM
5Y18
5Y6O
4MSV
5L19
5L36
Enriched GO Terms of Interacting Partners
?
PML Body
Identical Protein Binding
Nucleus
Nucleoplasm
Positive Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of RNA Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Cellular Response To Stress
Positive Regulation Of Biosynthetic Process
Regulation Of Primary Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of Macromolecule Metabolic Process
Regulation Of RNA Biosynthetic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
DNA Damage Response
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Metabolic Process
Regulation Of Programmed Cell Death
Negative Regulation Of Macromolecule Metabolic Process
Positive Regulation Of RNA Metabolic Process
Negative Regulation Of Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Signal Transduction
Apoptotic Signaling Pathway
Regulation Of Signal Transduction
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Apoptotic Process
Regulation Of Protein Metabolic Process
PML Body Organization
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Transcription By RNA Polymerase II
Nuclear Body
Regulation Of Gene Expression
Macromolecule Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Intracellular Signal Transduction
Apoptotic Process
Positive Regulation Of Apoptotic Process
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Transcription By RNA Polymerase II
Regulation Of Signaling
Positive Regulation Of Programmed Cell Death
Regulation Of Cell Communication
Positive Regulation Of Intracellular Signal Transduction
Programmed Cell Death
Phosphotyrosine Residue Binding
Non-membrane Spanning Protein Tyrosine Kinase Activity
Cytosol
Immune Response-activating Cell Surface Receptor Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Signal Transduction
Antigen Receptor-mediated Signaling Pathway
Immune Response-activating Signaling Pathway
Regulation Of Immune Response
Immune Response-regulating Signaling Pathway
T Cell Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Activation Of Immune Response
Regulation Of Intracellular Signal Transduction
Fc-gamma Receptor Signaling Pathway
Fc Receptor Signaling Pathway
Protein Tyrosine Kinase Activity
Plasma Membrane
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Fc Receptor Mediated Stimulatory Signaling Pathway
Regulation Of Cellular Component Organization
Cytoplasm
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Ephrin Receptor Binding
Peptidyl-tyrosine Phosphorylation
Negative Regulation Of Inflammatory Response To Antigenic Stimulus
Regulation Of Immune System Process
Positive Regulation Of Immune Response
Regulation Of Cell Shape
Regulation Of Cell Morphogenesis
Negative Regulation Of Immune System Process
Regulation Of Actin Filament-based Process
Positive Regulation Of Immune System Process
T Cell Costimulation
Regulation Of Cell Communication
Regulation Of Signaling
Regulation Of Actin Cytoskeleton Organization
Positive Regulation Of Actin Filament Polymerization
Regulation Of Signal Transduction
Developmental Process
Phospholipase Activator Activity
Endocytosis
B Cell Receptor Signaling Pathway
Regulation Of Cell Motility
Immune System Process
Regulation Of Cell Activation
Enzyme-linked Receptor Protein Signaling Pathway
Regulation Of Actin Polymerization Or Depolymerization
Anchoring Junction
Positive Regulation Of T Cell Activation
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