CYP2C9 and ECSIT

Number of citations of the paper that reports this interaction (PMID 21163940)
13

Data Source:
BioGRID (two hybrid)

		CYP2C9	ECSIT
Gene Name		cytochrome P450, family 2, subfamily C, polypeptide 9	ECSIT signalling integrator
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Membrane Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Mitochondrion
	Molecular Function	Monooxygenase Activity Iron Ion Binding Drug Binding Arachidonic Acid Epoxygenase Activity Steroid Hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen (S)-limonene 6-monooxygenase Activity (S)-limonene 7-monooxygenase Activity Oxygen Binding Heme Binding Caffeine Oxidase Activity (R)-limonene 6-monooxygenase Activity	Sequence-specific DNA Binding Transcription Factor Activity Signal Transducer Activity Protein Binding Oxidoreductase Activity, Acting On NAD(P)H
	Biological Process	Xenobiotic Metabolic Process Steroid Metabolic Process Monoterpenoid Metabolic Process Drug Metabolic Process Arachidonic Acid Metabolic Process Epoxygenase P450 Pathway Urea Metabolic Process Monocarboxylic Acid Metabolic Process Drug Catabolic Process Exogenous Drug Catabolic Process Cellular Amide Metabolic Process Small Molecule Metabolic Process Oxidation-reduction Process Oxidative Demethylation Omega-hydroxylase P450 Pathway	Mesoderm Formation BMP Signaling Pathway Innate Immune Response Regulation Of Oxidoreductase Activity Oxidation-reduction Process
Pathways		Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Metabolism of lipids and lipoproteins Metabolic disorders of biological oxidation enzymes Phase 1 - Functionalization of compounds Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Arachidonic acid metabolism Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Cytochrome P450 - arranged by substrate type CYP2E1 reactions Biological oxidations Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective FMO3 causes Trimethylaminuria (TMAU) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Defective CYP1B1 causes Glaucoma Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Xenobiotics Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
Drugs
Diseases
GWAS		Dehydroepiandrosterone sulphate levels ( 21533175) Immune response to smallpox vaccine (IL-6) ( 22542470) Response to clopidogrel therapy ( 19706858) Warfarin maintenance dose ( 18535201 23755828 20833655 19300499)
Protein-Protein Interactions		9 interactors: CDC37 CYP2D6 ECSIT MAST1 POR RAB3D RNF32 STAMBP STAT5A	42 interactors: A2M AP1M2 APOE APP BLMH CDC37 CEP55 CYP2C18 CYP2C8 CYP2C9 DNAJB1 ELAVL3 EXOC6 EXOSC1 FARSA FBXL12 FBXW4 GCDH IFIT3 IFIT5 IMMT LONP1 LOXL4 MAST1 NFKB1 PAXIP1 PI4K2A PRDX2 PSEN1 RAB3A RAD23A RELA RHEB RNF32 SETDB1 SMAD1 SMAD4 SMURF1 STAMBPL1 STRN4 TRAF6 TRIM59
Entrez ID		1559	51295
HPRD ID		03084	12225
Ensembl ID		ENSG00000138109	ENSG00000130159
Uniprot IDs		P11712 S5RV20	K7EMM0 Q9BQ95
PDB IDs		1OG2 1OG5 1R9O
Enriched GO Terms of Interacting Partners?		Fatty Acid Metabolic Process JAK-STAT Cascade Demethylation Regulation Of Oxidoreductase Activity Cellular Organofluorine Metabolic Process Negative Regulation Of Cellular Organofluorine Metabolic Process Positive Regulation Of Mast Cell Differentiation Nitrate Catabolic Process Nitric Oxide Catabolic Process Regulation Of Steroid Metabolic Process Regulation Of Growth Plate Cartilage Chondrocyte Proliferation Monocarboxylic Acid Metabolic Process Cellular Protein Metabolic Process Cellular Response To Stimulus Alkaloid Catabolic Process Regulation Of Mast Cell Differentiation Peptidyl-cysteine Methylation Nitrate Metabolic Process Development Of Secondary Male Sexual Characteristics Isoquinoline Alkaloid Metabolic Process Negative Regulation Of Mast Cell Apoptotic Process Creatinine Metabolic Process Cellular Protein Modification Process Regulation Of Mast Cell Apoptotic Process Monoterpenoid Metabolic Process Positive Regulation Of Mast Cell Proliferation Intracellular Signal Transduction Isoleucine Metabolic Process Allantoin Metabolic Process Positive Regulation Of Cholesterol Biosynthetic Process Taurine Metabolic Process Positive Regulation Of Gamma-delta T Cell Differentiation Positive Regulation Of Cholesterol Metabolic Process Positive Regulation Of Steroid Hormone Biosynthetic Process Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Erythrocyte Differentiation Coumarin Metabolic Process Prolactin Signaling Pathway Protein Metabolic Process Regulation Of Innate Immune Response Peptidyl-amino Acid Modification Positive Regulation Of Gamma-delta T Cell Activation Development Of Secondary Female Sexual Characteristics Cellular Lipid Metabolic Process Response To Stimulus Negative Regulation Of Cell Death Valine Metabolic Process Creatine Metabolic Process	Membrane Protein Proteolysis Regulation Of Interleukin-12 Biosynthetic Process Cellular Response To Interleukin-1 Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Epoxygenase P450 Pathway Membrane Protein Intracellular Domain Proteolysis Catabolic Process Response To Oxidative Stress Exogenous Drug Catabolic Process Drug Catabolic Process Response To Abiotic Stimulus Response To Interleukin-1 Protein Metabolic Process Response To Stress Exocytosis Negative Regulation Of Cell Death Proteolysis Response To Stimulus T Cell Receptor Signaling Pathway Intracellular Signal Transduction Positive Regulation Of MiRNA Metabolic Process Drug Metabolic Process Cellular Response To Growth Factor Stimulus Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway NIK/NF-kappaB Signaling Response To Growth Factor Regulation Of Innate Immune Response Antigen Receptor-mediated Signaling Pathway Cellular Response To Nicotine Positive Regulation Of Interleukin-12 Biosynthetic Process Omega-hydroxylase P450 Pathway Cellular Response To Stimulus Toll-like Receptor 5 Signaling Pathway Negative Regulation Of Apoptotic Process Toll-like Receptor 10 Signaling Pathway Negative Regulation Of Programmed Cell Death Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Regulation Of MiRNA Metabolic Process Negative Regulation Of Cholesterol Transport Regulation Of Interleukin-12 Production TRIF-dependent Toll-like Receptor Signaling Pathway Secretion By Cell Response To Drug SMAD Protein Complex Assembly Arachidonic Acid Metabolic Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway
Tagcloud ?		amiodarone azapropazone carbamazepine cbz clarithromycin cotrimoxazole cytochromes disulfiram epoxide felbamate flurythromycin hpph imipramine immunoinhibition josamycin macrolide mephenytoin miconazole omeprazole phenylbutazone pht ponsinomycin propoxyphene secondarily stiripentol sulfaphenazole tolbutamide troleandomycin	1beta abolished adapter attributed augments consequence cytotrap evidenced evolutionarily gst hbx hbxdelta51 helenalin hepatitis ikappabalpha ikk interacted interacting kappab knockdown mechanistically nf p50 p65 pull tlr toll transactivates transfection
Tagcloud (Difference) ?		amiodarone azapropazone carbamazepine cbz clarithromycin cotrimoxazole cytochromes disulfiram epoxide felbamate flurythromycin hpph imipramine immunoinhibition josamycin macrolide mephenytoin miconazole omeprazole phenylbutazone pht ponsinomycin propoxyphene secondarily stiripentol sulfaphenazole tolbutamide troleandomycin	1beta abolished adapter attributed augments consequence cytotrap evidenced evolutionarily gst hbx hbxdelta51 helenalin hepatitis ikappabalpha ikk interacted interacting kappab knockdown mechanistically nf p50 p65 pull tlr toll transactivates transfection
Tagcloud (Intersection) ?