CYP2C9 and RNF32

Number of citations of the paper that reports this interaction (PubMedID 21163940)
58

Data Source:
BioGRID (two hybrid)

		CYP2C9	RNF32
Description		cytochrome P450 family 2 subfamily C member 9	ring finger protein 32
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Intracellular Membrane-bounded Organelle	Cytoplasm Endosome Cytosol Aggresome Nuclear Body
	Molecular Function	Monooxygenase Activity Iron Ion Binding Arachidonate Epoxygenase Activity Steroid Hydroxylase Activity Arachidonate 14,15-epoxygenase Activity Arachidonate 11,12-epoxygenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen (S)-limonene 6-monooxygenase Activity (S)-limonene 7-monooxygenase Activity Heme Binding Caffeine Oxidase Activity Metal Ion Binding (R)-limonene 6-monooxygenase Activity Estrogen 2-hydroxylase Activity	Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Lipid Metabolic Process Terpenoid Metabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Cholesterol Metabolic Process Estrogen Metabolic Process Monoterpenoid Metabolic Process Arachidonate Metabolic Process Epoxygenase P450 Pathway Urea Metabolic Process Monocarboxylic Acid Metabolic Process Xenobiotic Catabolic Process Long-chain Fatty Acid Biosynthetic Process Icosanoid Biosynthetic Process Oxidative Demethylation Organofluorine Metabolic Process Omega-hydroxylase P450 Pathway
Pathways		Xenobiotics CYP2E1 reactions Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Biosynthesis of maresin-like SPMs Aspirin ADME
Drugs		Ferroheme C Diacerein Benzbromarone
Diseases
GWAS		Clopidogrel active metabolite levels ( 28207573) Dehydroepiandrosterone sulphate levels ( 21533175) Diastolic blood pressure ( 27841878) Glucocorticoid receptor gene expression in B-cell precursor acute lymphoblastic leukaemia ( 33002292) Immune response to smallpox vaccine (IL-6) ( 22542470) Plasma clozapine-norclozapine ratio in treatment-resistant schizophrenia ( 30922102) Pulse pressure ( 27841878) Response to clopidogrel therapy ( 19706858 28207573) Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels) ( 24528284) Serum metabolite levels ( 23093944) Systolic blood pressure ( 27841878) Warfarin maintenance dose ( 26265036 18535201 23755828 20833655 19300499)	Glomerular filtration rate (creatinine) ( 26831199)
Interacting Genes		10 interacting genes: CDC37 CYP2D6 CYP3A4 ECSIT MAST1 POR RAB3D RNF32 STAMBP STAT5A	42 interacting genes: A2M APOE APP BLMH CDC37 CDK5 CEP55 CYP2C8 CYP2C9 ECSIT ELAVL3 EXOC6 EXOSC1 FARSA FBXL12 FBXW4 FIBP GCDH HOXC4 IFIT3 IFIT5 LONP1 LOXL4 LZTS2 MAST1 MKRN3 MNAT1 NOS3 OGA PAXIP1 PRAM1 PRDX2 PSEN1 PSEN2 RAB3A RAB3D RAD23A RPP30 STAMBPL1 TRIM23 TRIM74 UBE2K
Entrez ID		1559	140545
HPRD ID		03084	11517
Ensembl ID		ENSG00000138109	ENSG00000105982
Uniprot IDs		P11712 S5RV20	G5E940 Q9H0A6
PDB IDs		1OG2 1OG5 1R9O 4NZ2 5A5I 5A5J 5K7K 5W0C 5X23 5X24 5XXI 6VLT 7RL2 8VX0 8VZ7
Enriched GO Terms of Interacting Partners?		Demethylation Anandamide 8,9 Epoxidase Activity Anandamide 11,12 Epoxidase Activity Anandamide 14,15 Epoxidase Activity Alkaloid Catabolic Process Monoterpenoid Metabolic Process Oxidative Demethylation Alkaloid Metabolic Process Xenobiotic Metabolic Process Intracellular Membrane-bounded Organelle Xenobiotic Catabolic Process Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Estrogen Metabolic Process Long-chain Fatty Acid Biosynthetic Process Retinol Metabolic Process Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Fatty Acid Metabolic Process Organic Acid Metabolic Process Isoquinoline Alkaloid Metabolic Process Negative Regulation Of Organofluorine Metabolic Process Secondary Metabolic Process Quinine 3-monooxygenase Activity 1,8-cineole 2-exo-monooxygenase Activity 1-alpha,25-dihydroxyvitamin D3 23-hydroxylase Activity Iron-cytochrome-c Reductase Activity Positive Regulation Of Growth Plate Cartilage Chondrocyte Proliferation Nitric Oxide Dioxygenase NAD(P)H Activity Nitrate Catabolic Process Monooxygenase Activity Cell Surface Receptor Signaling Pathway Via JAK-STAT Retinoid Metabolic Process Diterpenoid Metabolic Process Cell Surface Receptor Signaling Pathway Via STAT Vitamin D 24-hydroxylase Activity Vitamin D3 25-hydroxylase Activity Nitric Oxide Catabolic Process Organofluorine Metabolic Process Positive Regulation Of Mast Cell Differentiation HSP90-CDC37 Chaperone Complex Terpenoid Metabolic Process Long-chain Fatty Acid Metabolic Process Isoprenoid Metabolic Process Regulation Of Biological Quality Coumarin Metabolic Process Vitamin D Biosynthetic Process Calcitriol Biosynthetic Process From Calciol Vitamin D Catabolic Process Nitrate Metabolic Process NADPH-hemoprotein Reductase Activity Regulation Of Steroid Metabolic Process	Positive Regulation Of Amyloid Fibril Formation Lipoprotein Particle Catabolic Process Acetylcholine Receptor Activator Activity Cellular Response To Amyloid-beta Regulation Of Amyloid Fibril Formation Response To Amyloid-beta Amyloid Precursor Protein Metabolic Process Astrocyte Activation Involved In Immune Response Caffeine Oxidase Activity Intermediate-density Lipoprotein Particle Growth Factor Receptor Binding Aspartic Endopeptidase Activity, Intramembrane Cleaving Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Gamma-secretase Complex Regulation Of Synaptic Plasticity Macromolecule Catabolic Process Oxidative Demethylation Positive Regulation Of Regulated Secretory Pathway Regulation Of Regulated Secretory Pathway Omega-hydroxylase P450 Pathway Arachidonate Epoxygenase Activity Amyloid-beta Formation Notch Receptor Processing Regulation Of Proteolysis Regulation Of Vesicle-mediated Transport Demethylation Synaptic Vesicle Regulation Of Neuronal Synaptic Plasticity Regulation Of Postsynapse Organization Negative Regulation Of Long-term Synaptic Potentiation Growth Cone Regulation Of Immune Response Regulation Of Dendritic Spine Maintenance Neuron Projection Maintenance Epoxygenase P450 Pathway Synaptic Membrane Mitotic Cytokinesis Low-density Lipoprotein Particle Removal Of Superoxide Radicals Regulation Of Blood Coagulation Positive Regulation Of Membrane Protein Ectodomain Proteolysis Myosin V Binding Regulation Of Innate Immune Response Regulation Of Hemostasis Amyloid Precursor Protein Catabolic Process Maintenance Of Location In Cell Heparan Sulfate Proteoglycan Binding Negative Regulation Of Platelet Activation Astrocyte Activation
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