CYP2C9 and MAST1

Number of citations of the paper that reports this interaction (PubMedID 21163940)
58

Data Source:
BioGRID (two hybrid)

		CYP2C9	MAST1
Description		cytochrome P450 family 2 subfamily C member 9	microtubule associated serine/threonine kinase 1
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GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Intracellular Membrane-bounded Organelle	Cytoplasm Cytoskeleton Plasma Membrane Microtubule Cytoskeleton Membrane Axon Dendrite Cell Projection Neuron Projection Neuronal Cell Body
	Molecular Function	Monooxygenase Activity Iron Ion Binding Arachidonate Epoxygenase Activity Steroid Hydroxylase Activity Arachidonate 14,15-epoxygenase Activity Arachidonate 11,12-epoxygenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen (S)-limonene 6-monooxygenase Activity (S)-limonene 7-monooxygenase Activity Heme Binding Caffeine Oxidase Activity Metal Ion Binding (R)-limonene 6-monooxygenase Activity Estrogen 2-hydroxylase Activity	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Microtubule Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Lipid Metabolic Process Terpenoid Metabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Cholesterol Metabolic Process Estrogen Metabolic Process Monoterpenoid Metabolic Process Arachidonate Metabolic Process Epoxygenase P450 Pathway Urea Metabolic Process Monocarboxylic Acid Metabolic Process Xenobiotic Catabolic Process Long-chain Fatty Acid Biosynthetic Process Icosanoid Biosynthetic Process Oxidative Demethylation Organofluorine Metabolic Process Omega-hydroxylase P450 Pathway	Protein Phosphorylation Cytoskeleton Organization Brain Development Developmental Process Intracellular Signal Transduction
Pathways		Xenobiotics CYP2E1 reactions Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Biosynthesis of maresin-like SPMs Aspirin ADME
Drugs		Ferroheme C Diacerein Benzbromarone	Fostamatinib
Diseases
GWAS		Clopidogrel active metabolite levels ( 28207573) Dehydroepiandrosterone sulphate levels ( 21533175) Diastolic blood pressure ( 27841878) Glucocorticoid receptor gene expression in B-cell precursor acute lymphoblastic leukaemia ( 33002292) Immune response to smallpox vaccine (IL-6) ( 22542470) Plasma clozapine-norclozapine ratio in treatment-resistant schizophrenia ( 30922102) Pulse pressure ( 27841878) Response to clopidogrel therapy ( 19706858 28207573) Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels) ( 24528284) Serum metabolite levels ( 23093944) Systolic blood pressure ( 27841878) Warfarin maintenance dose ( 26265036 18535201 23755828 20833655 19300499)	High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 32888494) Intelligence (MTAG) ( 29326435) Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 27863252 32888494) Red blood cell count ( 29403010) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		10 interacting genes: CDC37 CYP2D6 CYP3A4 ECSIT MAST1 POR RAB3D RNF32 STAMBP STAT5A	41 interacting genes: A2M ACE2 AP1M2 APOE APP BLMH CDK5 CYP2C8 CYP2C9 DNAJB1 ECSIT EGFR ELAVL3 EXOC6 EXOSC1 FBXL12 FBXW4 GCDH IFIT3 IFIT5 LONP1 LOXL4 NOS3 OGA PAXIP1 PRAM1 PRDX2 PSEN2 PTEN RAB3A RAB3D RAD23A RNF32 RNLS RPP30 RPS6KA1 SNTA1 SNTB2 STAMBPL1 TIAM1 VANGL2
Entrez ID		1559	22983
HPRD ID		03084	17469
Ensembl ID		ENSG00000138109	ENSG00000105613
Uniprot IDs		P11712 S5RV20	Q9Y2H9
PDB IDs		1OG2 1OG5 1R9O 4NZ2 5A5I 5A5J 5K7K 5W0C 5X23 5X24 5XXI 6VLT 7RL2 8VX0 8VZ7	2M9X 3PS4
Enriched GO Terms of Interacting Partners?		Demethylation Anandamide 8,9 Epoxidase Activity Anandamide 11,12 Epoxidase Activity Anandamide 14,15 Epoxidase Activity Alkaloid Catabolic Process Monoterpenoid Metabolic Process Oxidative Demethylation Alkaloid Metabolic Process Xenobiotic Metabolic Process Intracellular Membrane-bounded Organelle Xenobiotic Catabolic Process Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Estrogen Metabolic Process Long-chain Fatty Acid Biosynthetic Process Retinol Metabolic Process Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Fatty Acid Metabolic Process Organic Acid Metabolic Process Isoquinoline Alkaloid Metabolic Process Negative Regulation Of Organofluorine Metabolic Process Secondary Metabolic Process Quinine 3-monooxygenase Activity 1,8-cineole 2-exo-monooxygenase Activity 1-alpha,25-dihydroxyvitamin D3 23-hydroxylase Activity Iron-cytochrome-c Reductase Activity Positive Regulation Of Growth Plate Cartilage Chondrocyte Proliferation Nitric Oxide Dioxygenase NAD(P)H Activity Nitrate Catabolic Process Monooxygenase Activity Cell Surface Receptor Signaling Pathway Via JAK-STAT Retinoid Metabolic Process Diterpenoid Metabolic Process Cell Surface Receptor Signaling Pathway Via STAT Vitamin D 24-hydroxylase Activity Vitamin D3 25-hydroxylase Activity Nitric Oxide Catabolic Process Organofluorine Metabolic Process Positive Regulation Of Mast Cell Differentiation HSP90-CDC37 Chaperone Complex Terpenoid Metabolic Process Long-chain Fatty Acid Metabolic Process Isoprenoid Metabolic Process Regulation Of Biological Quality Coumarin Metabolic Process Vitamin D Biosynthetic Process Calcitriol Biosynthetic Process From Calciol Vitamin D Catabolic Process Nitrate Metabolic Process NADPH-hemoprotein Reductase Activity Regulation Of Steroid Metabolic Process	Lipoprotein Particle Acetylcholine Receptor Activator Activity Negative Regulation Of Smooth Muscle Cell Proliferation Caffeine Oxidase Activity Intermediate-density Lipoprotein Particle Positive Regulation Of Amyloid Fibril Formation Chemical Synaptic Transmission Catabolic Process Cytosol Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Trans-synaptic Signaling Oxidative Demethylation Synaptic Signaling Cellular Response To Amyloid-beta Positive Regulation Of Regulated Secretory Pathway Regulation Of Regulated Secretory Pathway Omega-hydroxylase P450 Pathway Oxidoreductase Activity Arachidonate Epoxygenase Activity Regulation Of Neuronal Synaptic Plasticity Regulation Of Wound Healing Negative Regulation Of Long-term Synaptic Potentiation Regulation Of System Process Regulation Of Blood Circulation Demethylation Regulation Of Dendritic Spine Maintenance Response To Amyloid-beta Regulation Of Smooth Muscle Cell Proliferation Learning Or Memory Axonogenesis Epoxygenase P450 Pathway Low-density Lipoprotein Particle Removal Of Superoxide Radicals Negative Regulation Of Wound Healing Regulation Of Blood Coagulation Positive Regulation Of Membrane Protein Ectodomain Proteolysis Myosin V Binding Dystrophin-associated Glycoprotein Complex Regulation Of Hemostasis Heparan Sulfate Proteoglycan Binding Intracellular Signaling Cassette Regulation Of Amyloid Fibril Formation Regulation Of Response To Wounding Negative Regulation Of Platelet Activation Cognition Cellular Oxidant Detoxification Regulation Of Transport Ubiquitin-specific Protease Binding Very-low-density Lipoprotein Particle Regulation Of Amyloid-beta Clearance
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