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CYP2C9 and MAST1
Number of citations of the paper that reports this interaction (PMID
21163940
)
13
Data Source:
BioGRID
(two hybrid)
CYP2C9
MAST1
Gene Name
cytochrome P450, family 2, subfamily C, polypeptide 9
microtubule associated serine/threonine kinase 1
Image
Gene Ontology Annotations
Cellular Component
Cytoplasm
Endoplasmic Reticulum Membrane
Intracellular Membrane-bounded Organelle
Cytoplasm
Cytoskeleton
Plasma Membrane
Molecular Function
Monooxygenase Activity
Iron Ion Binding
Drug Binding
Arachidonic Acid Epoxygenase Activity
Steroid Hydroxylase Activity
Oxidoreductase Activity
Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen
(S)-limonene 6-monooxygenase Activity
(S)-limonene 7-monooxygenase Activity
Oxygen Binding
Heme Binding
Caffeine Oxidase Activity
(R)-limonene 6-monooxygenase Activity
Magnesium Ion Binding
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Biological Process
Xenobiotic Metabolic Process
Steroid Metabolic Process
Monoterpenoid Metabolic Process
Drug Metabolic Process
Arachidonic Acid Metabolic Process
Epoxygenase P450 Pathway
Urea Metabolic Process
Monocarboxylic Acid Metabolic Process
Drug Catabolic Process
Exogenous Drug Catabolic Process
Cellular Amide Metabolic Process
Small Molecule Metabolic Process
Oxidation-reduction Process
Oxidative Demethylation
Omega-hydroxylase P450 Pathway
Protein Phosphorylation
Cytoskeleton Organization
Intracellular Signal Transduction
Pathways
Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B)
Metabolism of lipids and lipoproteins
Metabolic disorders of biological oxidation enzymes
Phase 1 - Functionalization of compounds
Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A)
Arachidonic acid metabolism
Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4)
Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56)
Cytochrome P450 - arranged by substrate type
CYP2E1 reactions
Biological oxidations
Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD)
Defective FMO3 causes Trimethylaminuria (TMAU)
Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX)
Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4)
Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA)
Defective CYP1B1 causes Glaucoma
Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5)
Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3)
Defective CYP19A1 causes Aromatase excess syndrome (AEXS)
Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5)
Defective CYP24A1 causes Hypercalcemia, infantile (HCAI)
Xenobiotics
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
Defective MAOA causes Brunner syndrome (BRUNS)
Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency)
Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
Drugs
Diseases
GWAS
Dehydroepiandrosterone sulphate levels (
21533175
)
Immune response to smallpox vaccine (IL-6) (
22542470
)
Response to clopidogrel therapy (
19706858
)
Warfarin maintenance dose (
18535201
23755828
20833655
19300499
)
Protein-Protein Interactions
9 interactors:
CDC37
CYP2D6
ECSIT
MAST1
POR
RAB3D
RNF32
STAMBP
STAT5A
37 interactors:
A2M
AP1M2
APOE
APP
BLMH
CDK5
CYP2C8
CYP2C9
DNAJB1
ECSIT
EGFR
ELAVL3
EXOC6
EXOSC1
FBXL12
FBXW4
GCDH
IFIT3
IFIT5
LONP1
LOXL4
MGEA5
NOS3
PAXIP1
PRAM1
PRDX2
PSEN2
PTEN
RAB3A
RAB3D
RAD23A
RNF32
RNLS
RPP30
SNTA1
SNTB2
STAMBPL1
Entrez ID
1559
22983
HPRD ID
03084
17469
Ensembl ID
ENSG00000138109
ENSG00000105613
Uniprot IDs
P11712
S5RV20
Q9Y2H9
PDB IDs
1OG2
1OG5
1R9O
2M9X
3PS4
Enriched GO Terms of Interacting Partners
?
Fatty Acid Metabolic Process
JAK-STAT Cascade
Demethylation
Regulation Of Oxidoreductase Activity
Cellular Organofluorine Metabolic Process
Negative Regulation Of Cellular Organofluorine Metabolic Process
Positive Regulation Of Mast Cell Differentiation
Nitrate Catabolic Process
Nitric Oxide Catabolic Process
Regulation Of Steroid Metabolic Process
Regulation Of Growth Plate Cartilage Chondrocyte Proliferation
Monocarboxylic Acid Metabolic Process
Cellular Protein Metabolic Process
Cellular Response To Stimulus
Alkaloid Catabolic Process
Regulation Of Mast Cell Differentiation
Peptidyl-cysteine Methylation
Nitrate Metabolic Process
Development Of Secondary Male Sexual Characteristics
Isoquinoline Alkaloid Metabolic Process
Negative Regulation Of Mast Cell Apoptotic Process
Creatinine Metabolic Process
Cellular Protein Modification Process
Regulation Of Mast Cell Apoptotic Process
Monoterpenoid Metabolic Process
Positive Regulation Of Mast Cell Proliferation
Intracellular Signal Transduction
Isoleucine Metabolic Process
Allantoin Metabolic Process
Positive Regulation Of Cholesterol Biosynthetic Process
Taurine Metabolic Process
Positive Regulation Of Gamma-delta T Cell Differentiation
Positive Regulation Of Cholesterol Metabolic Process
Positive Regulation Of Steroid Hormone Biosynthetic Process
Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus
Negative Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Negative Regulation Of Erythrocyte Differentiation
Coumarin Metabolic Process
Prolactin Signaling Pathway
Protein Metabolic Process
Regulation Of Innate Immune Response
Peptidyl-amino Acid Modification
Positive Regulation Of Gamma-delta T Cell Activation
Development Of Secondary Female Sexual Characteristics
Cellular Lipid Metabolic Process
Response To Stimulus
Negative Regulation Of Cell Death
Valine Metabolic Process
Creatine Metabolic Process
Catabolic Process
Synapse Organization
Negative Regulation Of Protein Metabolic Process
Response To Stress
Negative Regulation Of Cellular Protein Metabolic Process
Response To Abiotic Stimulus
Negative Regulation Of Presynaptic Membrane Organization
Regulation Of Synaptic Plasticity
Regulation Of Synaptic Transmission
Regulation Of Oxidoreductase Activity
Synapse Assembly
Exocytosis
Regulation Of Cellular Protein Metabolic Process
Axon Development
Response To Stimulus
Regulation Of Presynaptic Membrane Organization
Regulation Of Nitric-oxide Synthase Activity
Regulation Of Protein Metabolic Process
Negative Regulation Of Dendritic Spine Development
Learning Or Memory
Regulation Of Proteolysis
Regulation Of Dendritic Spine Development
Negative Regulation Of Cell Death
Cognition
Omega-hydroxylase P450 Pathway
Synaptic Vesicle Exocytosis
Anatomical Structure Morphogenesis
Secretion By Cell
Vesicle Docking Involved In Exocytosis
Axonogenesis
Positive Regulation Of Exocytosis
Neuron Projection Development
Vesicle-mediated Transport
Glial Cell Differentiation
Protein Metabolic Process
Establishment Of Protein Localization
Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Cell Morphogenesis Involved In Neuron Differentiation
Negative Regulation Of Neuron Differentiation
Membrane Organization
Oxidative Demethylation
Protein Catabolic Process
Establishment Of Vesicle Localization
Oligodendrocyte Differentiation
Positive Regulation Of Catalytic Activity
Regulation Of ERBB Signaling Pathway
Vesicle Docking
Regulation Of Cellular Amino Acid Metabolic Process
Endothelial Cell Migration
Vesicle Localization
Tagcloud
?
amiodarone
azapropazone
carbamazepine
cbz
clarithromycin
cotrimoxazole
cytochromes
disulfiram
epoxide
felbamate
flurythromycin
hpph
imipramine
immunoinhibition
josamycin
macrolide
mephenytoin
miconazole
omeprazole
phenylbutazone
pht
ponsinomycin
propoxyphene
secondarily
stiripentol
sulfaphenazole
tolbutamide
troleandomycin
Tagcloud (Difference)
?
amiodarone
azapropazone
carbamazepine
cbz
clarithromycin
cotrimoxazole
cytochromes
disulfiram
epoxide
felbamate
flurythromycin
hpph
imipramine
immunoinhibition
josamycin
macrolide
mephenytoin
miconazole
omeprazole
phenylbutazone
pht
ponsinomycin
propoxyphene
secondarily
stiripentol
sulfaphenazole
tolbutamide
troleandomycin
Tagcloud (Intersection)
?