CYP2C9 and CYP2D6

Number of citations of the paper that reports this interaction (PMID 19448135)
12

Data Source:
BioGRID (pull down)

		CYP2C9	CYP2D6
Gene Name		cytochrome P450, family 2, subfamily C, polypeptide 9	cytochrome P450, family 2, subfamily D, polypeptide 6
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Membrane Intracellular Membrane-bounded Organelle	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane
	Molecular Function	Monooxygenase Activity Iron Ion Binding Drug Binding Arachidonic Acid Epoxygenase Activity Steroid Hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen (S)-limonene 6-monooxygenase Activity (S)-limonene 7-monooxygenase Activity Oxygen Binding Heme Binding Caffeine Oxidase Activity (R)-limonene 6-monooxygenase Activity	Monooxygenase Activity Iron Ion Binding Drug Binding Arachidonic Acid Epoxygenase Activity Steroid Hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Oxygen Binding Heme Binding Aromatase Activity
	Biological Process	Xenobiotic Metabolic Process Steroid Metabolic Process Monoterpenoid Metabolic Process Drug Metabolic Process Arachidonic Acid Metabolic Process Epoxygenase P450 Pathway Urea Metabolic Process Monocarboxylic Acid Metabolic Process Drug Catabolic Process Exogenous Drug Catabolic Process Cellular Amide Metabolic Process Small Molecule Metabolic Process Oxidation-reduction Process Oxidative Demethylation Omega-hydroxylase P450 Pathway	Xenobiotic Metabolic Process Steroid Metabolic Process Coumarin Metabolic Process Alkaloid Metabolic Process Alkaloid Catabolic Process Monoterpenoid Metabolic Process Drug Metabolic Process Arachidonic Acid Metabolic Process Isoquinoline Alkaloid Metabolic Process Drug Catabolic Process Exogenous Drug Catabolic Process Small Molecule Metabolic Process Heterocycle Metabolic Process Negative Regulation Of Binding Oxidation-reduction Process Oxidative Demethylation Negative Regulation Of Cellular Organofluorine Metabolic Process
Pathways		Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Metabolism of lipids and lipoproteins Metabolic disorders of biological oxidation enzymes Phase 1 - Functionalization of compounds Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Arachidonic acid metabolism Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Cytochrome P450 - arranged by substrate type CYP2E1 reactions Biological oxidations Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective FMO3 causes Trimethylaminuria (TMAU) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Defective CYP1B1 causes Glaucoma Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Xenobiotics Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)	Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Metabolic disorders of biological oxidation enzymes Phase 1 - Functionalization of compounds Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Cytochrome P450 - arranged by substrate type CYP2E1 reactions Biological oxidations Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective FMO3 causes Trimethylaminuria (TMAU) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Miscellaneous substrates Defective CYP1B1 causes Glaucoma Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Fatty acids Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Xenobiotics Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
Drugs			Paliperidone
Diseases
GWAS		Dehydroepiandrosterone sulphate levels ( 21533175) Immune response to smallpox vaccine (IL-6) ( 22542470) Response to clopidogrel therapy ( 19706858) Warfarin maintenance dose ( 18535201 23755828 20833655 19300499)
Protein-Protein Interactions		9 interactors: CDC37 CYP2D6 ECSIT MAST1 POR RAB3D RNF32 STAMBP STAT5A	3 interactors: CYB5A CYP2C9 POR
Entrez ID		1559	1565
HPRD ID		03084	00487
Ensembl ID		ENSG00000138109	ENSG00000100197
Uniprot IDs		P11712 S5RV20	C1ID52 P10635 Q5Y7H2
PDB IDs		1OG2 1OG5 1R9O	2F9Q 3QM4 3TBG 3TDA
Enriched GO Terms of Interacting Partners?		Fatty Acid Metabolic Process JAK-STAT Cascade Demethylation Regulation Of Oxidoreductase Activity Cellular Organofluorine Metabolic Process Negative Regulation Of Cellular Organofluorine Metabolic Process Positive Regulation Of Mast Cell Differentiation Nitrate Catabolic Process Nitric Oxide Catabolic Process Regulation Of Steroid Metabolic Process Regulation Of Growth Plate Cartilage Chondrocyte Proliferation Monocarboxylic Acid Metabolic Process Cellular Protein Metabolic Process Cellular Response To Stimulus Alkaloid Catabolic Process Regulation Of Mast Cell Differentiation Peptidyl-cysteine Methylation Nitrate Metabolic Process Development Of Secondary Male Sexual Characteristics Isoquinoline Alkaloid Metabolic Process Negative Regulation Of Mast Cell Apoptotic Process Creatinine Metabolic Process Cellular Protein Modification Process Regulation Of Mast Cell Apoptotic Process Monoterpenoid Metabolic Process Positive Regulation Of Mast Cell Proliferation Intracellular Signal Transduction Isoleucine Metabolic Process Allantoin Metabolic Process Positive Regulation Of Cholesterol Biosynthetic Process Taurine Metabolic Process Positive Regulation Of Gamma-delta T Cell Differentiation Positive Regulation Of Cholesterol Metabolic Process Positive Regulation Of Steroid Hormone Biosynthetic Process Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Erythrocyte Differentiation Coumarin Metabolic Process Prolactin Signaling Pathway Protein Metabolic Process Regulation Of Innate Immune Response Peptidyl-amino Acid Modification Positive Regulation Of Gamma-delta T Cell Activation Development Of Secondary Female Sexual Characteristics Cellular Lipid Metabolic Process Response To Stimulus Negative Regulation Of Cell Death Valine Metabolic Process Creatine Metabolic Process	Demethylation Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Cellular Organofluorine Metabolic Process Nitric Oxide Catabolic Process Nitrate Catabolic Process Regulation Of Growth Plate Cartilage Chondrocyte Proliferation Oxidation-reduction Process Nitrate Metabolic Process Fatty Acid Metabolic Process Monoterpenoid Metabolic Process Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Cholesterol Metabolic Process Positive Regulation Of Steroid Hormone Biosynthetic Process Small Molecule Metabolic Process Omega-hydroxylase P450 Pathway Positive Regulation Of Hormone Biosynthetic Process Response To Drug L-ascorbic Acid Metabolic Process Oxidative Demethylation Urea Metabolic Process Monocarboxylic Acid Metabolic Process Carnitine Metabolic Process Cellular Response To Follicle-stimulating Hormone Stimulus Epoxygenase P450 Pathway Amino-acid Betaine Metabolic Process Negative Regulation Of Lipase Activity Regulation Of Cholesterol Biosynthetic Process Exogenous Drug Catabolic Process Response To Follicle-stimulating Hormone Drug Catabolic Process Cellular Response To Gonadotropin Stimulus Flavonoid Metabolic Process Positive Regulation Of Monooxygenase Activity Regulation Of Hormone Biosynthetic Process Positive Regulation Of Steroid Metabolic Process Nitric Oxide Metabolic Process Regulation Of Cholesterol Metabolic Process Reactive Nitrogen Species Metabolic Process Positive Regulation Of Chondrocyte Differentiation Regulation Of Hormone Metabolic Process Drug Metabolic Process Cellular Lipid Metabolic Process Positive Regulation Of Oxidoreductase Activity Response To Gonadotropin Positive Regulation Of Cartilage Development Positive Regulation Of Smoothened Signaling Pathway Response To Cadmium Ion Positive Regulation Of Lipid Biosynthetic Process Arachidonic Acid Metabolic Process
Tagcloud ?		amiodarone azapropazone carbamazepine cbz clarithromycin cotrimoxazole cytochromes disulfiram epoxide felbamate flurythromycin hpph imipramine immunoinhibition josamycin macrolide mephenytoin miconazole omeprazole phenylbutazone pht ponsinomycin propoxyphene secondarily stiripentol sulfaphenazole tolbutamide troleandomycin	ab associations bcc bccs comprised cytochrome em genotypes glutathione gstm1 gstt1 heterogeneity lesion mpp null numbers p450 phenotype presentation presentations reflect reflects spp subgroup subgroups transferase truncal unidentified uv
Tagcloud (Difference) ?		amiodarone azapropazone carbamazepine cbz clarithromycin cotrimoxazole cytochromes disulfiram epoxide felbamate flurythromycin hpph imipramine immunoinhibition josamycin macrolide mephenytoin miconazole omeprazole phenylbutazone pht ponsinomycin propoxyphene secondarily stiripentol sulfaphenazole tolbutamide troleandomycin	ab associations bcc bccs comprised cytochrome em genotypes glutathione gstm1 gstt1 heterogeneity lesion mpp null numbers p450 phenotype presentation presentations reflect reflects spp subgroup subgroups transferase truncal unidentified uv
Tagcloud (Intersection) ?