CYP2C9

Gene Name		cytochrome P450, family 2, subfamily C, polypeptide 9
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Gene Ontology Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Monooxygenase Activity Iron Ion Binding Drug Binding Arachidonic Acid Epoxygenase Activity Steroid Hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen (S)-limonene 6-monooxygenase Activity (S)-limonene 7-monooxygenase Activity Oxygen Binding Heme Binding Caffeine Oxidase Activity (R)-limonene 6-monooxygenase Activity
	Biological Process	Xenobiotic Metabolic Process Steroid Metabolic Process Monoterpenoid Metabolic Process Drug Metabolic Process Arachidonic Acid Metabolic Process Epoxygenase P450 Pathway Urea Metabolic Process Monocarboxylic Acid Metabolic Process Drug Catabolic Process Exogenous Drug Catabolic Process Cellular Amide Metabolic Process Small Molecule Metabolic Process Oxidation-reduction Process Oxidative Demethylation Omega-hydroxylase P450 Pathway
Pathways		Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Metabolism of lipids and lipoproteins Metabolic disorders of biological oxidation enzymes Phase 1 - Functionalization of compounds Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Arachidonic acid metabolism Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Cytochrome P450 - arranged by substrate type CYP2E1 reactions Biological oxidations Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective FMO3 causes Trimethylaminuria (TMAU) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Defective CYP1B1 causes Glaucoma Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Xenobiotics Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
Drugs
Diseases
GWAS		Dehydroepiandrosterone sulphate levels ( 21533175) Immune response to smallpox vaccine (IL-6) ( 22542470) Response to clopidogrel therapy ( 19706858) Warfarin maintenance dose ( 18535201 23755828 20833655 19300499)
Protein-protein Interactions		9 interactors: CDC37 CYP2D6 ECSIT MAST1 POR RAB3D RNF32 STAMBP STAT5A
Entrez ID		1559
HPRD ID		03084
Ensembl ID		ENSG00000138109
Uniprot IDs		P11712 S5RV20
PDB IDs		1OG2 1OG5 1R9O
Enriched GO Terms of Interacting Partners?		Fatty Acid Metabolic Process JAK-STAT Cascade Demethylation Regulation Of Oxidoreductase Activity Cellular Organofluorine Metabolic Process Negative Regulation Of Cellular Organofluorine Metabolic Process Positive Regulation Of Mast Cell Differentiation Nitrate Catabolic Process Nitric Oxide Catabolic Process Regulation Of Steroid Metabolic Process Regulation Of Growth Plate Cartilage Chondrocyte Proliferation Monocarboxylic Acid Metabolic Process Cellular Protein Metabolic Process Cellular Response To Stimulus Alkaloid Catabolic Process Regulation Of Mast Cell Differentiation Peptidyl-cysteine Methylation Nitrate Metabolic Process Development Of Secondary Male Sexual Characteristics Isoquinoline Alkaloid Metabolic Process Negative Regulation Of Mast Cell Apoptotic Process Creatinine Metabolic Process Cellular Protein Modification Process Regulation Of Mast Cell Apoptotic Process Monoterpenoid Metabolic Process Positive Regulation Of Mast Cell Proliferation Intracellular Signal Transduction Isoleucine Metabolic Process Allantoin Metabolic Process Positive Regulation Of Cholesterol Biosynthetic Process Taurine Metabolic Process Positive Regulation Of Gamma-delta T Cell Differentiation Positive Regulation Of Cholesterol Metabolic Process Positive Regulation Of Steroid Hormone Biosynthetic Process Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Erythrocyte Differentiation Coumarin Metabolic Process Prolactin Signaling Pathway Protein Metabolic Process Regulation Of Innate Immune Response Peptidyl-amino Acid Modification Positive Regulation Of Gamma-delta T Cell Activation Development Of Secondary Female Sexual Characteristics Cellular Lipid Metabolic Process Response To Stimulus Negative Regulation Of Cell Death Valine Metabolic Process Creatine Metabolic Process
Tagcloud ?		amiodarone azapropazone carbamazepine cbz clarithromycin cotrimoxazole cytochromes disulfiram epoxide felbamate flurythromycin hpph imipramine immunoinhibition josamycin macrolide mephenytoin miconazole omeprazole phenylbutazone pht ponsinomycin propoxyphene secondarily stiripentol sulfaphenazole tolbutamide troleandomycin