CCDC50 and RNF8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CCDC50	RNF8
Description		coiled-coil domain containing 50	ring finger protein 8
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GO Annotations	Cellular Component	Cytoplasm Cytosol Ciliary Basal Body	Ubiquitin Ligase Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Midbody Site Of Double-strand Break
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Protein Ligase Binding Histone Binding Identical Protein Binding Protein Homodimerization Activity Ubiquitin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Sensory Perception Of Sound	DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Chromatin Organization Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Response To Ionizing Radiation Protein Ubiquitination Negative Regulation Of Transcription Elongation By RNA Polymerase II Sperm DNA Condensation Interstrand Cross-link Repair Epigenetic Regulation Of Gene Expression Signal Transduction In Response To DNA Damage Isotype Switching Positive Regulation Of DNA Repair Cell Division Protein Autoubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K6-linked Ubiquitination DNA Repair-dependent Chromatin Remodeling Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Protein Localization To Site Of Double-strand Break
Pathways			Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint
Drugs
Diseases
GWAS		Alzheimer's disease biomarkers ( 23562540) Lung cancer in never smokers ( 28604730)	Acne (severe) ( 24927181) Restless legs syndrome ( 29029846)
Interacting Genes		14 interacting genes: ARRDC3 HNRNPA1 IFIH1 MAP1LC3B MAVS RIGI RIPK1 RNF26 RNF8 RPS3A SH3GL1 STING1 TNFAIP3 UBC	78 interacting genes: AMOTL2 BLM CALCOCO1 CATSPERT CCDC14 CCDC50 CCDC85B CEP44 CEP85 CFLAR CHD4 CHEK2 CLK2 CLK3 DNM2 DNTTIP2 EPN2 EPN3 EXOSC2 FAM9B FSD2 GPRASP2 H2AC20 H2AC4 H2AX H2BC21 H2BC3 HOMEZ JMJD1C KDM4A KIF24 KMT5A KRTAP10-1 KRTAP10-8 KRTAP9-2 KRTAP9-8 LMO4 MAD1L1 MAGED1 MAPK1 MDC1 MDM2 NONO PCYT1A PGRMC2 PICK1 PNMA2 POLD4 RBFOX2 RECQL4 RXRA RYBP SCN3B SEPTIN3 SH3GL3 STX11 SUMO2 SUMO3 TMEM79 TNIP1 TOMM20L TRIM29 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2N UBE2V2 UBE2W VCP WASL XRN2 YEATS4 ZBTB10 ZNF346 ZNF496
Entrez ID		152137	9025
HPRD ID		06463	11521
Ensembl ID		ENSG00000152492	ENSG00000112130
Uniprot IDs		Q8IVM0	O76064
PDB IDs		6LAN	2CSW 2PIE 4AYC 4ORH 4WHV
Enriched GO Terms of Interacting Partners?		Regulation Of Defense Response To Virus Positive Regulation Of Response To Cytokine Stimulus Cellular Response To DsRNA Cellular Response To Exogenous DsRNA Cytoplasmic Pattern Recognition Receptor Signaling Pathway Response To Exogenous DsRNA Positive Regulation Of Interferon-beta Production Regulation Of Defense Response To Virus By Host Response To DsRNA Regulation Of Type I Interferon Production Ubiquitin Protein Ligase Binding Regulation Of Interferon-beta Production Pattern Recognition Receptor Signaling Pathway Regulation Of Tumor Necrosis Factor Production Innate Immune Response-activating Signaling Pathway Antiviral Innate Immune Response Activation Of Innate Immune Response Positive Regulation Of Type I Interferon Production Intracellular Receptor Signaling Pathway Positive Regulation Of Defense Response Positive Regulation Of Interferon-alpha Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Regulation Of Cytokine Production Regulation Of Defense Response Positive Regulation Of Defense Response To Virus By Host Identical Protein Binding Detection Of Virus Positive Regulation Of Innate Immune Response Regulation Of Interleukin-6 Production Single-stranded RNA Binding Immune Response-activating Signaling Pathway Regulation Of Type III Interferon Production Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Myeloid Dendritic Cell Cytokine Production MRNA Transcription Immune Response-regulating Signaling Pathway Positive Regulation Of Interleukin-8 Production Activation Of Immune Response Positive Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Innate Immune Response Signaling Adaptor Activity Positive Regulation Of Dendritic Cell Cytokine Production Positive Regulation Of Cytokine Production Regulation Of Interleukin-8 Production Positive Regulation Of Interleukin-6 Production Defense Response To Virus Regulation Of Dendritic Cell Cytokine Production Positive Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of Immune System Process	Ubiquitin Conjugating Enzyme Activity Nucleus Protein Polyubiquitination Nucleoplasm DNA Damage Response DNA Repair Protein Modification By Small Protein Conjugation Protein Monoubiquitination Protein Ubiquitination DNA Metabolic Process Post-translational Protein Modification Protein K63-linked Ubiquitination Protein Binding Identical Protein Binding Ubiquitin-protein Transferase Activity Negative Regulation Of Biosynthetic Process Protein Modification Process Double-strand Break Repair Protein K48-linked Ubiquitination Regulation Of Nucleobase-containing Compound Metabolic Process Chromosome DNA Recombination Negative Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Chromosome, Telomeric Region Nucleosome Negative Regulation Of Membrane Tubulation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Protein K11-linked Ubiquitination Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Macromolecule Metabolic Process Recombinational Repair Structural Constituent Of Chromatin DNA/DNA Annealing Activity Regulation Of Double-strand Break Repair UBC13-MMS2 Complex Cellular Response To Stress Ubiquitin Protein Ligase Binding Positive Regulation Of Protein Polyubiquitination Regulation Of Metabolic Process Positive Regulation Of Double-strand Break Repair Telomeric D-loop Binding ISG15 Transferase Activity Ubiquitin Conjugating Enzyme Complex Regulation Of RNA Metabolic Process ATP Binding
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