CCDC50 and RPS3A

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		CCDC50	RPS3A
Gene Name		coiled-coil domain containing 50	ribosomal protein S3A
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Nucleus Nucleolus Cytoplasm Cytosol Focal Adhesion Cytosolic Small Ribosomal Subunit Ribonucleoprotein Complex Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding	RNA Binding Structural Constituent Of Ribosome Protein Binding Poly(A) RNA Binding
	Biological Process		Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cytoplasmic Translation Translation Translational Initiation Translational Elongation Translational Termination SRP-dependent Cotranslational Protein Targeting To Membrane Gene Expression Viral Process Viral Life Cycle Viral Transcription Cell Differentiation Negative Regulation Of Apoptotic Process Cellular Protein Metabolic Process
Pathways			Nonsense-Mediated Decay (NMD) Translation initiation complex formation Translation SRP-dependent cotranslational protein targeting to membrane Eukaryotic Translation Termination Peptide chain elongation Influenza Infection Viral mRNA Translation L13a-mediated translational silencing of Ceruloplasmin expression Influenza Life Cycle Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosomal scanning and start codon recognition Formation of the ternary complex, and subsequently, the 43S complex Influenza Viral RNA Transcription and Replication GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Eukaryotic Translation Elongation Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Alzheimer's disease biomarkers ( 23562540)	HDL cholesterol ( 20686565)
Protein-Protein Interactions		4 interactors: RIPK1 RPS3A TNFAIP3 UBC	15 interactors: ATF7IP C11orf49 CCDC50 CHN1 DDIT3 EDEM2 FANCC HGS HSP90AA1 NEDD4 PARP1 SAP18 SOD2 TOE1 VDAC2
Entrez ID		152137	6189
HPRD ID		06463	01606
Ensembl ID		ENSG00000152492	ENSG00000145425
Uniprot IDs		Q8IVM0	B7Z3M5 P61247
PDB IDs			3J3A
Enriched GO Terms of Interacting Partners?		Regulation Of Type I Interferon Production Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Innate Immune Response Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Apoptotic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Cell Death Negative Regulation Of Type I Interferon Production Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Immune Response-regulating Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Cytokine Production MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Type I Interferon Production Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Immune Response JNK Cascade Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Protein Ubiquitination Regulation Of Protein Kinase Activity Toll-like Receptor Signaling Pathway Regulation Of Kinase Activity Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Innate Immune Response Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Negative Regulation Of Toll-like Receptor 5 Signaling Pathway Negative Regulation Of CD40 Signaling Pathway Regulation Of ATP:ADP Antiporter Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Cellular Macromolecule Catabolic Process Regulation Of Immune Response Activation Of MAPK Activity Positive Regulation Of Immune System Process Positive Regulation Of Cellular Protein Catabolic Process Apoptotic Process Programmed Cell Death Protein Polyubiquitination Negative Regulation Of Toll-like Receptor 3 Signaling Pathway	Cellular Response To Superoxide Response To Superoxide Response To Oxygen Radical Cellular Response To Reactive Oxygen Species Protein Targeting To Lysosome Reactive Oxygen Species Metabolic Process Protein Localization To Lysosome Removal Of Superoxide Radicals Response To Unfolded Protein Cellular Response To Stress Positive Regulation Of Metabolic Process Protein Targeting To Vacuole Response To Inorganic Substance Establishment Of Protein Localization To Vacuole Response To Reactive Oxygen Species Cellular Response To Oxidative Stress Negative Regulation Of Signal Transduction Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Signal Transduction Negative Regulation Of RNA Biosynthetic Process Superoxide Metabolic Process Negative Regulation Of Signaling Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Lysosomal Transport Regulation Of Signaling Negative Regulation Of Gene Expression Cytoplasmic Transport Negative Regulation Of Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Reactive Oxygen Species Biosynthetic Process Response To Stress Negative Regulation Of Determination Of Dorsal Identity Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Vasodilation By Acetylcholine Involved In Regulation Of Systemic Arterial Blood Pressure Erythrophore Differentiation Age-dependent Response To Reactive Oxygen Species Transmission Of Virus Development Involved In Symbiotic Interaction Cellular Response To DNA Damage Stimulus Establishment Of Protein Localization To Organelle Vacuolar Transport Positive Regulation Of Cellular Biosynthetic Process Response To Organic Substance Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Reactive Oxygen Species Metabolic Process Neuron Development
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