CCDC50 and MAVS

Number of citations of the paper that reports this interaction (PubMedID 32612200)
53

Data Source:
BioGRID (pull down)

		CCDC50	MAVS
Description		coiled-coil domain containing 50	mitochondrial antiviral signaling protein
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Ciliary Basal Body	Ubiquitin Ligase Complex Mitochondrion Mitochondrial Outer Membrane Peroxisome Peroxisomal Membrane Membrane Mitochondrial Membrane
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding	Protein Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Signaling Adaptor Activity Identical Protein Binding CARD Domain Binding Molecular Adaptor Activity Protein Serine/threonine Kinase Binding DNA-binding Transcription Factor Binding Molecular Condensate Scaffold Activity
	Biological Process	Sensory Perception Of Sound	Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Immune System Process Positive Regulation Of Myeloid Dendritic Cell Cytokine Production Cytoplasmic Pattern Recognition Receptor Signaling Pathway Signal Transduction MRNA Transcription Positive Regulation Of Type I Interferon Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Intracellular Signal Transduction Positive Regulation Of Protein Import Into Nucleus Defense Response To Bacterium Positive Regulation Of Canonical NF-kappaB Signal Transduction NLRP3 Inflammasome Complex Assembly Negative Regulation Of Viral Genome Replication Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Virus Type I Interferon-mediated Signaling Pathway Positive Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Protein Localization To Mitochondrion Cellular Response To Exogenous DsRNA Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of IP-10 Production Antiviral Innate Immune Response Regulation Of Peroxisome Organization Positive Regulation Of NLRP3 Inflammasome Complex Assembly
Pathways			DDX58/IFIH1-mediated induction of interferon-alpha/beta Ovarian tumor domain proteases TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses Evasion by RSV of host interferon responses PKR-mediated signaling
Drugs
Diseases
GWAS		Alzheimer's disease biomarkers ( 23562540) Lung cancer in never smokers ( 28604730)	Platelet distribution width ( 32888494)
Interacting Genes		14 interacting genes: ARRDC3 HNRNPA1 IFIH1 MAP1LC3B MAVS RIGI RIPK1 RNF26 RNF8 RPS3A SH3GL1 STING1 TNFAIP3 UBC	32 interacting genes: ABL1 CCDC50 CNTN1 DDX3X EIF2AK2 IKBKB IRF3 IRF5 IRF7 KCNIP3 MAP1LC3A MAP3K7 OAS3 OTUD4 RIGI RIPK2 RNF115 RNF125 RNF135 RNF34 SMURF2 STAT1 TBK1 TICAM1 TNKS TNKS2 TRAF3 TRAF6 TRIM31 UBC UBE4A USP25
Entrez ID		152137	57506
HPRD ID		06463	13847
Ensembl ID		ENSG00000152492	ENSG00000088888
Uniprot IDs		Q8IVM0	Q7Z434
PDB IDs		6LAN	2MS7 2MS8 2VGQ 3J6C 3J6J 3RC5 4P4H 4Z8M 5JEK 7DNI 8WKW
Enriched GO Terms of Interacting Partners?		Regulation Of Defense Response To Virus Positive Regulation Of Response To Cytokine Stimulus Cellular Response To DsRNA Cellular Response To Exogenous DsRNA Cytoplasmic Pattern Recognition Receptor Signaling Pathway Response To Exogenous DsRNA Positive Regulation Of Interferon-beta Production Regulation Of Defense Response To Virus By Host Response To DsRNA Regulation Of Type I Interferon Production Ubiquitin Protein Ligase Binding Regulation Of Interferon-beta Production Pattern Recognition Receptor Signaling Pathway Regulation Of Tumor Necrosis Factor Production Innate Immune Response-activating Signaling Pathway Antiviral Innate Immune Response Activation Of Innate Immune Response Positive Regulation Of Type I Interferon Production Intracellular Receptor Signaling Pathway Positive Regulation Of Defense Response Positive Regulation Of Interferon-alpha Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Regulation Of Cytokine Production Regulation Of Defense Response Positive Regulation Of Defense Response To Virus By Host Identical Protein Binding Detection Of Virus Positive Regulation Of Innate Immune Response Regulation Of Interleukin-6 Production Single-stranded RNA Binding Immune Response-activating Signaling Pathway Regulation Of Type III Interferon Production Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Myeloid Dendritic Cell Cytokine Production MRNA Transcription Immune Response-regulating Signaling Pathway Positive Regulation Of Interleukin-8 Production Activation Of Immune Response Positive Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Innate Immune Response Signaling Adaptor Activity Positive Regulation Of Dendritic Cell Cytokine Production Positive Regulation Of Cytokine Production Regulation Of Interleukin-8 Production Positive Regulation Of Interleukin-6 Production Defense Response To Virus Regulation Of Dendritic Cell Cytokine Production Positive Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of Immune System Process	Positive Regulation Of Type I Interferon Production Pattern Recognition Receptor Signaling Pathway Regulation Of Type I Interferon Production Innate Immune Response-activating Signaling Pathway Cytoplasmic Pattern Recognition Receptor Signaling Pathway Activation Of Innate Immune Response Immune Response-activating Signaling Pathway Regulation Of Innate Immune Response Positive Regulation Of Innate Immune Response Regulation Of Interferon-beta Production Positive Regulation Of Interferon-beta Production Immune Response-regulating Signaling Pathway Activation Of Immune Response Intracellular Receptor Signaling Pathway Response To Virus Regulation Of Defense Response Positive Regulation Of Defense Response Defense Response To Virus Positive Regulation Of Interferon-alpha Production Antiviral Innate Immune Response Positive Regulation Of Cytokine Production Regulation Of Immune Response Positive Regulation Of Immune Response Regulation Of Cytokine Production Protein Polyubiquitination Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Innate Immune Response Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Defense Response To Symbiont MyD88-independent Toll-like Receptor Signaling Pathway Protein Ubiquitination Defense Response To Other Organism Response To Other Organism Response To External Biotic Stimulus Regulation Of Immune System Process Immune Response Protein Modification By Small Protein Conjugation Immune System Process Positive Regulation Of Immune System Process Defense Response Protein Modification Process Cytokine-mediated Signaling Pathway Post-translational Protein Modification Positive Regulation Of Gene Expression Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Cytosol
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