CCDC50 and IFIH1

Number of citations of the paper that reports this interaction (PubMedID 32612200)
53

Data Source:
BioGRID (pull down, affinity chromatography technology)

		CCDC50	IFIH1
Description		coiled-coil domain containing 50	interferon induced with helicase C domain 1
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Ciliary Basal Body	Nucleus Cytoplasm Mitochondrion Cytosol
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding	Nucleotide Binding DNA Binding RNA Binding RNA Helicase Activity Double-stranded RNA Binding Single-stranded RNA Binding Helicase Activity Protein Binding ATP Binding Zinc Ion Binding Hydrolase Activity ATP Hydrolysis Activity Pattern Recognition Receptor Activity Identical Protein Binding Ribonucleoprotein Complex Binding Metal Ion Binding
	Biological Process	Sensory Perception Of Sound	Immune System Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway Signal Transduction MRNA Transcription Detection Of Virus Response To Virus Protein Sumoylation Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Type III Interferon Production MDA-5 Signaling Pathway Negative Regulation Of Viral Genome Replication Innate Immune Response Protein Complex Oligomerization Defense Response To Virus Type I Interferon-mediated Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Cellular Response To Exogenous DsRNA Cellular Response To Virus Antiviral Innate Immune Response
Pathways			DDX58/IFIH1-mediated induction of interferon-alpha/beta Ub-specific processing proteases Ovarian tumor domain proteases TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses Evasion by RSV of host interferon responses Modulation of host responses by IFN-stimulated genes
Drugs
Diseases			Type I diabetes mellitus
GWAS		Alzheimer's disease biomarkers ( 23562540) Lung cancer in never smokers ( 28604730)	Autoimmune thyroid disease ( 32581359) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Coronary artery disease ( 33020668) HDL cholesterol levels ( 32203549) Immunoglobulin A ( 20694011) Inflammatory bowel disease ( 23128233) Inflammatory skin disease ( 25574825) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Psoriasis ( 23143594 25903422 25574825 20953190) Psoriasis vulgaris ( 26626624) Selective IgA deficiency ( 27723758) Systemic lupus erythematosus ( 26502338 28714469 27399966 19838195) Type 1 diabetes ( 17554260 30572963 25751624 21829393 19430480) Vitiligo ( 27723757 22561518) White blood cell count ( 32888494)
Interacting Genes		14 interacting genes: ARRDC3 HNRNPA1 IFIH1 MAP1LC3B MAVS RIGI RIPK1 RNF26 RNF8 RPS3A SH3GL1 STING1 TNFAIP3 UBC	9 interacting genes: APP CCDC50 KEAP1 RNF10 RNF135 TRIM40 TRIM65 USP3 ZCCHC3
Entrez ID		152137	64135
HPRD ID		06463	09507
Ensembl ID		ENSG00000152492	ENSG00000115267
Uniprot IDs		Q8IVM0	Q9BYX4
PDB IDs		6LAN	2RQB 3B6E 3GA3 4GL2 7DNI 7DNJ 7JL0 7JL2
Enriched GO Terms of Interacting Partners?		Regulation Of Defense Response To Virus Positive Regulation Of Response To Cytokine Stimulus Cellular Response To DsRNA Cellular Response To Exogenous DsRNA Cytoplasmic Pattern Recognition Receptor Signaling Pathway Response To Exogenous DsRNA Positive Regulation Of Interferon-beta Production Regulation Of Defense Response To Virus By Host Response To DsRNA Regulation Of Type I Interferon Production Ubiquitin Protein Ligase Binding Regulation Of Interferon-beta Production Pattern Recognition Receptor Signaling Pathway Regulation Of Tumor Necrosis Factor Production Innate Immune Response-activating Signaling Pathway Antiviral Innate Immune Response Activation Of Innate Immune Response Positive Regulation Of Type I Interferon Production Intracellular Receptor Signaling Pathway Positive Regulation Of Defense Response Positive Regulation Of Interferon-alpha Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Regulation Of Cytokine Production Regulation Of Defense Response Positive Regulation Of Defense Response To Virus By Host Identical Protein Binding Detection Of Virus Positive Regulation Of Innate Immune Response Regulation Of Interleukin-6 Production Single-stranded RNA Binding Immune Response-activating Signaling Pathway Regulation Of Type III Interferon Production Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Myeloid Dendritic Cell Cytokine Production MRNA Transcription Immune Response-regulating Signaling Pathway Positive Regulation Of Interleukin-8 Production Activation Of Immune Response Positive Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Innate Immune Response Signaling Adaptor Activity Positive Regulation Of Dendritic Cell Cytokine Production Positive Regulation Of Cytokine Production Regulation Of Interleukin-8 Production Positive Regulation Of Interleukin-6 Production Defense Response To Virus Regulation Of Dendritic Cell Cytokine Production Positive Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of Immune System Process	Post-translational Protein Modification Innate Immune Response Positive Regulation Of Type I Interferon Production Protein Modification By Small Protein Conjugation Defense Response To Symbiont Defense Response To Other Organism Ubiquitin Protein Ligase Activity Regulation Of Type I Interferon Production Metal Ion Binding Protein Modification Process Positive Regulation Of Cytokine Production Response To Other Organism Positive Regulation Of Interferon-beta Production Immune Response Protein Metabolic Process Protein Ubiquitination Zinc Ion Binding Negative Regulation Of Protein Localization To Nucleus Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Response To Stress Amylin Binding Positive Regulation Of Toll Signaling Pathway Defense Response Response To External Biotic Stimulus Glycerol-3-phosphate Dehydrogenase (quinone) Activity Protein Polyubiquitination Defense Response To Virus Regulation Of Interferon-beta Production Protein K63-linked Ubiquitination Regulation Of Cytokine Production Regulation Of Defense Response Antiviral Innate Immune Response Acetylcholine Receptor Activator Activity Regulation Of Protein Catabolic Process Lipoprotein Particle Positive Regulation Of Protein Import Glycerol-3-phosphate Shuttle Response To Virus PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Non-canonical NF-kappaB Signal Transduction Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Positive Regulation Of Multicellular Organismal Process Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development
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