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CTSS and PLCG1
Number of citations of the paper that reports this interaction (PubMedID
9164868
)
26
Data Source:
HPRD
(in vitro, in vivo)
CTSS
PLCG1
Description
cathepsin S
phospholipase C gamma 1
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Lysosome
Late Endosome
Extracellular Matrix
Cytoplasmic Vesicle
Endolysosome Lumen
Lysosomal Lumen
Phagocytic Vesicle
Tertiary Granule Lumen
Ficolin-1-rich Granule Lumen
Ruffle
Cytoplasm
Cytosol
Plasma Membrane
COP9 Signalosome
Lamellipodium
Ruffle Membrane
Cell Projection
Molecular Function
Fibronectin Binding
Cysteine-type Endopeptidase Activity
Serine-type Endopeptidase Activity
Protein Binding
Collagen Binding
Peptidase Activity
Cysteine-type Peptidase Activity
Hydrolase Activity
Laminin Binding
Proteoglycan Binding
Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity
Phospholipase C Activity
Guanyl-nucleotide Exchange Factor Activity
Neurotrophin TRKA Receptor Binding
Calcium Ion Binding
Protein Binding
Phosphoric Diester Hydrolase Activity
Hydrolase Activity
Protein Kinase Binding
Metal Ion Binding
Calcium-dependent Phospholipase C Activity
Phosphatidylinositol Phospholipase C Activity
Biological Process
Toll-like Receptor Signaling Pathway
Adaptive Immune Response
Regulation Of Antigen Processing And Presentation
Proteolysis
Immune Response
Response To Acidic PH
Protein Processing
Antigen Processing And Presentation
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Extracellular Matrix Disassembly
Collagen Catabolic Process
Basement Membrane Disassembly
Antigen Processing And Presentation Of Peptide Antigen
Proteolysis Involved In Protein Catabolic Process
Cellular Response To Thyroid Hormone Stimulus
Positive Regulation Of Cation Channel Activity
Negative Regulation Of Inflammatory Response To Antigenic Stimulus
Lipid Metabolic Process
Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Phospholipid Catabolic Process
Positive Regulation Of Epithelial Cell Migration
Lipid Catabolic Process
Cell Migration
Calcium-mediated Signaling
Intracellular Signal Transduction
Fc-epsilon Receptor Signaling Pathway
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of Angiogenesis
Phosphatidylinositol Metabolic Process
Phosphatidylinositol-mediated Signaling
Antigen Receptor-mediated Signaling Pathway
T Cell Receptor Signaling Pathway
Release Of Sequestered Calcium Ion Into Cytosol
Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Regulation Of Sequestering Of Calcium Ion
Cellular Response To Epidermal Growth Factor Stimulus
Positive Regulation Of Vascular Endothelial Cell Proliferation
Positive Regulation Of Endothelial Cell Apoptotic Process
Pathways
Endosomal/Vacuolar pathway
Degradation of the extracellular matrix
Degradation of the extracellular matrix
Trafficking and processing of endosomal TLR
Assembly of collagen fibrils and other multimeric structures
MHC class II antigen presentation
Neutrophil degranulation
Degradation of CDH1
ISG15 antiviral mechanism
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
PLCG1 events in ERBB2 signaling
DAG and IP3 signaling
PLC-gamma1 signalling
Synthesis of IP3 and IP4 in the cytosol
Downstream signal transduction
Signaling by ALK
Generation of second messenger molecules
Role of phospholipids in phagocytosis
Role of phospholipids in phagocytosis
PECAM1 interactions
EGFR interacts with phospholipase C-gamma
DAP12 signaling
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
FCERI mediated Ca+2 mobilization
Role of second messengers in netrin-1 signaling
VEGFR2 mediated cell proliferation
VEGFR2 mediated cell proliferation
Constitutive Signaling by EGFRvIII
Phospholipase C-mediated cascade: FGFR1
Phospholipase C-mediated cascade; FGFR2
Phospholipase C-mediated cascade; FGFR3
Phospholipase C-mediated cascade; FGFR4
Signaling by FGFR2 in disease
Signaling by FGFR4 in disease
Signaling by FGFR1 in disease
Signaling by FGFR3 in disease
RET signaling
Activated NTRK2 signals through PLCG1
Activated NTRK2 signals through PLCG1
Erythropoietin activates Phospholipase C gamma (PLCG)
Activated NTRK3 signals through PLCG1
Activated NTRK3 signals through PLCG1
FCGR3A-mediated IL10 synthesis
Signaling by ERBB2 KD Mutants
Signaling by ERBB2 ECD mutants
Signaling by ERBB2 TMD/JMD mutants
Signaling by ALK fusions and activated point mutants
Drugs
Morpholine-4-Carboxylic Acid [1s-(2-Benzyloxy-1r-Cyano-Ethylcarbamoyl)-3-Methyl-Butyl]Amide
Morpholine-4-Carboxylic Acid (1-(3-Benzenesulfonyl-1-Phenethylallylcarbamoyl)-3-Methylbutyl)-Amide
Morpholine-4-Carboxylic Acid [1-(2-Benzylsulfanyl-1-Formyl-Ethylcarbamoyl)-2-Phenyl-Ethyl]-Amide
N-[1-(AMINOMETHYL)CYCLOPROPYL]-3-(MORPHOLIN-4-YLSULFONYL)-N~2~-[(1S)-2,2,2-TRIFLUORO-1-(4-FLUOROPHENYL)ETHYL]-L-ALANINAMIDE
N-(1-CYANOCYCLOPROPYL)-3-({[(2S)-5-OXOPYRROLIDIN-2-YL]METHYL}SULFONYL)-N~2~-[(1S)-2,2,2-TRIFLUORO-1-(4-FLUOROPHENYL)ETHYL]-L-ALANINAMIDE
N-[1-(AMINOMETHYL)CYCLOPROPYL]-3-(BENZYLSULFONYL)-N~2~-[(1S)-2,2,2-TRIFLUORO-1-(4-HYDROXYPHENYL)ETHYL]-L-ALANINAMIDE
N~2~-1,3-BENZOXAZOL-2-YL-3-CYCLOHEXYL-N-{2-[(4-METHOXYPHENYL)AMINO]ETHYL}-L-ALANINAMIDE
N-[(1S)-1-{1-[(1R,3E)-1-ACETYLPENT-3-EN-1-YL]-1H-1,2,3-TRIAZOL-4-YL}-1,2-DIMETHYLPROPYL]BENZAMIDE
(1R)-2-[(CYANOMETHYL)AMINO]-1-({[2-(DIFLUOROMETHOXY)BENZYL]SULFONYL}METHYL)-2-OXOETHYL MORPHOLINE-4-CARBOXYLATE
2-[(2',3',4'-TRIFLUOROBIPHENYL-2-YL)OXY]ETHANOL
N-[(1S)-2-[(4-cyano-1-methylpiperidin-4-yl)amino]-1-(cyclohexylmethyl)-2-oxoethyl]morpholine-4-carboxamide
N-[(1S)-2-{[(1R)-2-(benzyloxy)-1-cyano-1-methylethyl]amino}-1-(cyclohexylmethyl)-2-oxoethyl]morpholine-4-carboxamide
Fostamatinib
Diseases
GWAS
Aspartate aminotransferase levels (
33547301
)
Basal cell carcinoma (
33549134
)
Blood protein levels (
30072576
)
Body mass index (
26426971
)
Caffeine consumption from coffee (
33287642
)
Caffeine consumption from coffee or tea (
33287642
)
Congenital left-sided heart lesions (
26965164
)
Coronary artery disease (
32469254
)
Fat body mass (
24064335
)
Lymphocyte percentage of white cells (
32888494
)
Mean platelet volume (
32888494
)
Rhegmatogenous retinal detachment (
23585552
)
Apolipoprotein B levels (
32203549
)
Birth weight (
31043758
)
Brain morphology (MOSTest) (
32665545
)
Hemoglobin concentration (
27863252
)
Hemoglobin levels (
32327693
)
LDL cholesterol levels (
32203549
)
Major depressive disorder (
27479909
)
Male-pattern baldness (
28196072
)
Refractive error (
32231278
)
Triglyceride levels (
32203549
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Interacting Genes
9 interacting genes:
ANXA2
BGLAP
CST3
CST5
KNG1
PLCG1
SERPINB3
SERPINB4
SLPI
112 interacting genes:
ABL1
AGAP2
AGTR1
AKT1
ALK
AR
ARHGAP32
ARHGEF5
AXL
BAG3
BCR
BLNK
BTK
CBL
CD22
CD28
CTSS
DAB1
DAPP1
DDR1
DGKZ
DNM1
DOK1
EEF1A1
EGFR
EPHB2
EPOR
ERBB2
ERBB3
ERBB4
FGFR1
FGFR2
FGFR4
FLT1
FYN
GAB1
GAB2
GHR
GIT1
GRAP
GRB2
GRIN1
GRIN2A
GRIN2B
GSN
GTF2H1
HCK
INPP5D
INSR
IRS2
ITK
KDR
KHDRBS1
KIT
LAT
LAT2
LCK
LCP2
LIFR
LYN
MAPT
MET
MST1R
NCAM1
NCK1
NPM1
NTRK1
NTRK2
NTRK3
PAK1
PDGFRA
PDGFRB
PECAM1
PICALM
PITPNA
PKN2
PLD2
PRKD1
PRMT8
PTK2
PTPN11
PTPRJ
RACK1
RBM11
RET
RHOA
RHOU
SELE
SH2D2A
SH3BP2
SHB
SHC1
SNAP91
SOCS7
SOS1
SOS2
SRC
SYK
SYN1
SYNCRIP
TEC
TNK1
TRIM14
TRPC3
TRPM7
TUB
USO1
VAV1
VAV3
VIL1
WAS
ZAP70
Entrez ID
1520
5335
HPRD ID
00292
01398
Ensembl ID
ENSG00000163131
ENSG00000124181
Uniprot IDs
P25774
P19174
PDB IDs
1GLO
1MS6
1NPZ
1NQC
2C0Y
2F1G
2FQ9
2FRA
2FRQ
2FT2
2FUD
2FYE
2G6D
2G7Y
2H7J
2HH5
2HHN
2HXZ
2OP3
2R9M
2R9N
2R9O
3IEJ
3N3G
3N4C
3OVX
4P6E
4P6G
5QBU
5QBV
5QBW
5QBX
5QBY
5QBZ
5QC0
5QC1
5QC2
5QC3
5QC4
5QC5
5QC6
5QC7
5QC8
5QC9
5QCA
5QCB
5QCC
5QCD
5QCE
5QCF
5QCG
5QCH
5QCI
5QCJ
6YYN
6YYO
6YYP
6YYQ
6YYR
8PI3
8RND
9GJ2
1HSQ
2HSP
4EY0
4FBN
7NXE
Enriched GO Terms of Interacting Partners
?
Peptidase Inhibitor Activity
Cysteine-type Endopeptidase Inhibitor Activity
Endopeptidase Inhibitor Activity
Vesicle
Extracellular Space
Serine-type Endopeptidase Inhibitor Activity
Protease Binding
Regulation Of Proteolysis
Negative Regulation Of Proteolysis
Negative Regulation Of Protein Metabolic Process
Extracellular Region
Negative Regulation Of Peptidase Activity
Negative Regulation Of Hydrolase Activity
Extracellular Exosome
Negative Regulation Of Blood Coagulation
Negative Regulation Of Hemostasis
Negative Regulation Of Coagulation
Endoplasmic Reticulum Lumen
Regulation Of Protein Metabolic Process
Negative Regulation Of Collagen Catabolic Process
Negative Regulation Of Elastin Catabolic Process
Negative Regulation Of Wound Healing
Regulation Of Hemostasis
Regulation Of Blood Coagulation
Response To Activity
Regulation Of Tissue Remodeling
Positive Regulation Of Receptor-mediated Endocytosis Involved In Cholesterol Transport
Azurophil Granule Lumen
AnxA2-p11 Complex
PCSK9-AnxA2 Complex
Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process
Negative Regulation Of Bone Development
Structural Constituent Of Bone
Negative Regulation Of Blood Vessel Remodeling
Calcium-dependent Phospholipase C Activity
Extracellular Matrix
Regulation Of Multicellular Organismal Process
Negative Regulation Of Receptor Catabolic Process
Positive Regulation Of Intracellular Cholesterol Transport
Hormone Activity
Negative Regulation Of Protein Catabolic Process
Positive Regulation Of Low-density Lipoprotein Particle Clearance
Positive Regulation Of Plasma Membrane Repair
Positive Regulation Of Intracellular Lipid Transport
Negative Regulation Of Multicellular Organismal Process
Hydroxyapatite Binding
Regulation Of Collagen Catabolic Process
Regulation Of Wound Healing
Myelin Sheath Adaxonal Region
Response To Vitamin K
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Protein Tyrosine Kinase Activity
Enzyme-linked Receptor Protein Signaling Pathway
Cell Surface Receptor Signaling Pathway
Signal Transduction
Peptidyl-tyrosine Phosphorylation
Transmembrane Receptor Protein Tyrosine Kinase Activity
Protein Kinase Activity
Plasma Membrane
Kinase Activity
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Intracellular Signal Transduction
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Immune Response-activating Cell Surface Receptor Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Protein Phosphorylation
Phosphorylation
Regulation Of Signal Transduction
Protein Autophosphorylation
Positive Regulation Of Signal Transduction
Cell Migration
Regulation Of Signaling
Regulation Of Cell Communication
Intracellular Signal Transduction
Positive Regulation Of MAPK Cascade
Immune Response-activating Signaling Pathway
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of MAPK Cascade
Immune Response-regulating Signaling Pathway
Receptor Complex
Antigen Receptor-mediated Signaling Pathway
Cell Motility
Activation Of Immune Response
Immune System Process
Intracellular Signaling Cassette
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Cell Population Proliferation
Fc Receptor Signaling Pathway
ATP Binding
Cell Activation
Positive Regulation Of Cellular Component Organization
Regulation Of Cell Population Proliferation
Response To Growth Factor
Developmental Process
Nucleotide Binding
Leukocyte Activation
Regulation Of Immune Response
Positive Regulation Of Immune System Process
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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