CTSS and BGLAP

Number of citations of the paper that reports this interaction (PMID 9076588)
4

Data Source:
HPRD (in vivo)

		CTSS	BGLAP
Gene Name		cathepsin S	bone gamma-carboxyglutamate (gla) protein
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Membrane Endolysosome Lumen Lysosomal Lumen Intracellular Membrane-bounded Organelle	Extracellular Space Cytoplasm Rough Endoplasmic Reticulum Golgi Apparatus Dendrite Membrane-bounded Vesicle Perikaryon
	Molecular Function	Fibronectin Binding Cysteine-type Endopeptidase Activity Collagen Binding Laminin Binding Proteoglycan Binding	Structural Molecule Activity Calcium Ion Binding Structural Constituent Of Bone Hydroxyapatite Binding
	Biological Process	Toll-like Receptor Signaling Pathway Adaptive Immune Response Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Proteolysis Immune Response Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Basement Membrane Disassembly Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Innate Immune Response Positive Regulation Of Inflammatory Response Proteolysis Involved In Cellular Protein Catabolic Process Cellular Response To Thyroid Hormone Stimulus	Skeletal System Development Osteoblast Differentiation Osteoblast Development Cell Adhesion Cell Aging Response To Mechanical Stimulus Response To Gravity Response To Zinc Ion Response To Activity Bone Mineralization Regulation Of Bone Mineralization Response To Vitamin K Response To Vitamin D Response To Testosterone Response To Hydroxyisoflavone Odontogenesis Response To Drug Response To Estrogen Regulation Of Bone Resorption Response To Ethanol Regulation Of Osteoclast Differentiation Response To Glucocorticoid Bone Development Cellular Response To Vitamin D Cellular Response To Growth Factor Stimulus
Pathways		Toll-Like Receptors Cascades Trafficking and processing of endosomal TLR Collagen formation MHC class II antigen presentation Endosomal/Vacuolar pathway Class I MHC mediated antigen processing & presentation Antigen processing-Cross presentation Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Adaptive Immune System Innate Immune System
Drugs		Morpholine-4-Carboxylic Acid [1s-(2-Benzyloxy-1r-Cyano-Ethylcarbamoyl)-3-Methyl-Butyl]Amide Morpholine-4-Carboxylic Acid (1-(3-Benzenesulfonyl-1-Phenethylallylcarbamoyl)-3-Methylbutyl)-Amide Morpholine-4-Carboxylic Acid [1-(2-Benzylsulfanyl-1-Formyl-Ethylcarbamoyl)-2-Phenyl-Ethyl]-Amide N-[1-(AMINOMETHYL)CYCLOPROPYL]-3-(MORPHOLIN-4-YLSULFONYL)-N~2~-[(1S)-2,2,2-TRIFLUORO-1-(4-FLUOROPHENYL)ETHYL]-L-ALANINAMIDE N-(1-CYANOCYCLOPROPYL)-3-({[(2S)-5-OXOPYRROLIDIN-2-YL]METHYL}SULFONYL)-N~2~-[(1S)-2,2,2-TRIFLUORO-1-(4-FLUOROPHENYL)ETHYL]-L-ALANINAMIDE N-[1-(AMINOMETHYL)CYCLOPROPYL]-3-(BENZYLSULFONYL)-N~2~-[(1S)-2,2,2-TRIFLUORO-1-(4-HYDROXYPHENYL)ETHYL]-L-ALANINAMIDE N~2~-1,3-BENZOXAZOL-2-YL-3-CYCLOHEXYL-N-{2-[(4-METHOXYPHENYL)AMINO]ETHYL}-L-ALANINAMIDE N-[(1S)-1-{1-[(1R,3E)-1-ACETYLPENT-3-EN-1-YL]-1H-1,2,3-TRIAZOL-4-YL}-1,2-DIMETHYLPROPYL]BENZAMIDE (1R)-2-[(CYANOMETHYL)AMINO]-1-({[2-(DIFLUOROMETHOXY)BENZYL]SULFONYL}METHYL)-2-OXOETHYL MORPHOLINE-4-CARBOXYLATE 2-[(2\',3\',4\'-TRIFLUOROBIPHENYL-2-YL)OXY]ETHANOL N-[(1S)-2-[(4-cyano-1-methylpiperidin-4-yl)amino]-1-(cyclohexylmethyl)-2-oxoethyl]morpholine-4-carboxamide N-[(1S)-2-{[(1R)-2-(benzyloxy)-1-cyano-1-methylethyl]amino}-1-(cyclohexylmethyl)-2-oxoethyl]morpholine-4-carboxamide	Menadione Phytonadione Gamma-Carboxy-Glutamic Acid Gallium nitrate
Diseases
GWAS		Rhegmatogenous retinal detachment ( 23585552)	mean corpuscular hemoglobin concentration ( 20139978)
Protein-Protein Interactions		8 interactors: BGLAP CST3 CST5 KNG1 PLCG1 SERPINB3 SERPINB4 SLPI	5 interactors: CTSB CTSD CTSH CTSS GGCX
Entrez ID		1520	632
HPRD ID		00292	00205
Ensembl ID		ENSG00000163131
Uniprot IDs		P25774	P02818
PDB IDs		1BXF 1GLO 1MS6 1NPZ 1NQC 2C0Y 2F1G 2FQ9 2FRA 2FRQ 2FT2 2FUD 2FYE 2G6D 2G7Y 2H7J 2HH5 2HHN 2HXZ 2OP3 2R9M 2R9N 2R9O 3IEJ 3KWN 3MPE 3MPF 3N3G 3N4C 3OVX
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Regulation Of Proteolysis Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Negative Regulation Of Cellular Metabolic Process Regulation Of Tissue Remodeling Negative Regulation Of Elastin Catabolic Process Negative Regulation Of Blood Vessel Remodeling Negative Regulation Of Collagen Catabolic Process Response To Vitamin K Regulation Of Collagen Catabolic Process Regulation Of Ion Homeostasis Negative Regulation Of Extracellular Matrix Organization Negative Regulation Of Extracellular Matrix Disassembly Regulation Of Metabolic Process Regulation Of Blood Vessel Remodeling Response To Hydroxyisoflavone Negative Regulation Of Multicellular Organismal Metabolic Process Regulation Of Cellular Process Positive Regulation Of Renal Sodium Excretion Negative Regulation Of Glycoprotein Metabolic Process Extracellular Fibril Organization Blood Coagulation, Intrinsic Pathway Positive Regulation Of Urine Volume Response To Gravity Negative Regulation Of Tissue Remodeling Cellular Response To Vitamin D Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Renal Sodium Excretion Defense Response Blood Coagulation Regulation Of Excretion Hemostasis Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Phospholipid Catabolic Process Osteoblast Development Response To Epidermal Growth Factor Regulation Of Extracellular Matrix Disassembly	Cellular Response To Thyroid Hormone Stimulus Response To Thyroid Hormone Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Antigen Processing And Presentation Extracellular Matrix Organization Extracellular Structure Organization Immune Response-regulating Signaling Pathway Proteolysis Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Cellular Response To Hormone Stimulus Catabolic Process Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Immune System Process Activation Of Innate Immune Response Basement Membrane Disassembly Neuropeptide Catabolic Process Regulation Of Immune Response Positive Regulation Of Innate Immune Response Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Response To Hormone Protein Metabolic Process Antigen Processing And Presentation Of Peptide Antigen Regulation Of Innate Immune Response Bradykinin Catabolic Process Adaptive Immune Response Immune Response Regulation Of Immune System Process Peptidyl-glutamic Acid Carboxylation T Cell Mediated Cytotoxicity Surfactant Homeostasis Peptide Catabolic Process Chemical Homeostasis Within A Tissue ERK1 And ERK2 Cascade Decidualization Basement Membrane Organization Cellular Response To Organic Substance Protein Destabilization Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Maternal Placenta Development Leukocyte Mediated Cytotoxicity
Tagcloud ?		amounts bacteriuria capability capacitance capacitive consuming demand dissolved distinguishing exponential feasible fem finite gave giving ionic liquids measurable portable proposes sensor simulations solutions tangible top touch urine utis volumes	a2 a5 alkaline altered annexin annexins anxa2 anxa5 col1a1 else fibrinolysis generate ibsp knock knockdown mineralizing osteoblasts osteogenesis osteogenic osteoprogenitor programming psiren rafts responsiveness runx2 shrna si stat6 vesicles
Tagcloud (Difference) ?		amounts bacteriuria capability capacitance capacitive consuming demand dissolved distinguishing exponential feasible fem finite gave giving ionic liquids measurable portable proposes sensor simulations solutions tangible top touch urine utis volumes	a2 a5 alkaline altered annexin annexins anxa2 anxa5 col1a1 else fibrinolysis generate ibsp knock knockdown mineralizing osteoblasts osteogenesis osteogenic osteoprogenitor programming psiren rafts responsiveness runx2 shrna si stat6 vesicles
Tagcloud (Intersection) ?