CTSS and CST3

Number of citations of the paper that reports this interaction (PMID 7890620)
16

Data Source:
HPRD (in vitro)

		CTSS	CST3
Gene Name		cathepsin S	cystatin C
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Membrane Endolysosome Lumen Lysosomal Lumen Intracellular Membrane-bounded Organelle	Extracellular Region Extracellular Space Extracellular Vesicular Exosome
	Molecular Function	Fibronectin Binding Cysteine-type Endopeptidase Activity Collagen Binding Laminin Binding Proteoglycan Binding	Beta-amyloid Binding Protease Binding Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding
	Biological Process	Toll-like Receptor Signaling Pathway Adaptive Immune Response Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Proteolysis Immune Response Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Basement Membrane Disassembly Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Innate Immune Response Positive Regulation Of Inflammatory Response Proteolysis Involved In Cellular Protein Catabolic Process Cellular Response To Thyroid Hormone Stimulus	Defense Response Negative Regulation Of Peptidase Activity Negative Regulation Of Collagen Catabolic Process Negative Regulation Of Extracellular Matrix Disassembly Negative Regulation Of Endopeptidase Activity Regulation Of Tissue Remodeling Extracellular Fibril Organization Negative Regulation Of Proteolysis Negative Regulation Of Elastin Catabolic Process Negative Regulation Of Blood Vessel Remodeling
Pathways		Toll-Like Receptors Cascades Trafficking and processing of endosomal TLR Collagen formation MHC class II antigen presentation Endosomal/Vacuolar pathway Class I MHC mediated antigen processing & presentation Antigen processing-Cross presentation Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Adaptive Immune System Innate Immune System	Amyloids
Drugs		Morpholine-4-Carboxylic Acid [1s-(2-Benzyloxy-1r-Cyano-Ethylcarbamoyl)-3-Methyl-Butyl]Amide Morpholine-4-Carboxylic Acid (1-(3-Benzenesulfonyl-1-Phenethylallylcarbamoyl)-3-Methylbutyl)-Amide Morpholine-4-Carboxylic Acid [1-(2-Benzylsulfanyl-1-Formyl-Ethylcarbamoyl)-2-Phenyl-Ethyl]-Amide N-[1-(AMINOMETHYL)CYCLOPROPYL]-3-(MORPHOLIN-4-YLSULFONYL)-N~2~-[(1S)-2,2,2-TRIFLUORO-1-(4-FLUOROPHENYL)ETHYL]-L-ALANINAMIDE N-(1-CYANOCYCLOPROPYL)-3-({[(2S)-5-OXOPYRROLIDIN-2-YL]METHYL}SULFONYL)-N~2~-[(1S)-2,2,2-TRIFLUORO-1-(4-FLUOROPHENYL)ETHYL]-L-ALANINAMIDE N-[1-(AMINOMETHYL)CYCLOPROPYL]-3-(BENZYLSULFONYL)-N~2~-[(1S)-2,2,2-TRIFLUORO-1-(4-HYDROXYPHENYL)ETHYL]-L-ALANINAMIDE N~2~-1,3-BENZOXAZOL-2-YL-3-CYCLOHEXYL-N-{2-[(4-METHOXYPHENYL)AMINO]ETHYL}-L-ALANINAMIDE N-[(1S)-1-{1-[(1R,3E)-1-ACETYLPENT-3-EN-1-YL]-1H-1,2,3-TRIAZOL-4-YL}-1,2-DIMETHYLPROPYL]BENZAMIDE (1R)-2-[(CYANOMETHYL)AMINO]-1-({[2-(DIFLUOROMETHOXY)BENZYL]SULFONYL}METHYL)-2-OXOETHYL MORPHOLINE-4-CARBOXYLATE 2-[(2\',3\',4\'-TRIFLUOROBIPHENYL-2-YL)OXY]ETHANOL N-[(1S)-2-[(4-cyano-1-methylpiperidin-4-yl)amino]-1-(cyclohexylmethyl)-2-oxoethyl]morpholine-4-carboxamide N-[(1S)-2-{[(1R)-2-(benzyloxy)-1-cyano-1-methylethyl]amino}-1-(cyclohexylmethyl)-2-oxoethyl]morpholine-4-carboxamide
Diseases
GWAS		Rhegmatogenous retinal detachment ( 23585552)	Chronic kidney disease ( 20383146) Cystatin C ( 17903292)
Protein-Protein Interactions		8 interactors: BGLAP CST3 CST5 KNG1 PLCG1 SERPINB3 SERPINB4 SLPI	9 interactors: ATXN1 C4A CSTB CTSB CTSD CTSL CTSS PDZD2 RNF115
Entrez ID		1520	1471
HPRD ID		00292	05056
Ensembl ID		ENSG00000163131	ENSG00000101439
Uniprot IDs		P25774	P01034
PDB IDs		1BXF 1GLO 1MS6 1NPZ 1NQC 2C0Y 2F1G 2FQ9 2FRA 2FRQ 2FT2 2FUD 2FYE 2G6D 2G7Y 2H7J 2HH5 2HHN 2HXZ 2OP3 2R9M 2R9N 2R9O 3IEJ 3KWN 3MPE 3MPF 3N3G 3N4C 3OVX	1G96 1R4C 1TIJ 3GAX 3NX0 3PS8 3QRD 3S67 3SVA
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Regulation Of Proteolysis Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Negative Regulation Of Cellular Metabolic Process Regulation Of Tissue Remodeling Negative Regulation Of Elastin Catabolic Process Negative Regulation Of Blood Vessel Remodeling Negative Regulation Of Collagen Catabolic Process Response To Vitamin K Regulation Of Collagen Catabolic Process Regulation Of Ion Homeostasis Negative Regulation Of Extracellular Matrix Organization Negative Regulation Of Extracellular Matrix Disassembly Regulation Of Metabolic Process Regulation Of Blood Vessel Remodeling Response To Hydroxyisoflavone Negative Regulation Of Multicellular Organismal Metabolic Process Regulation Of Cellular Process Positive Regulation Of Renal Sodium Excretion Negative Regulation Of Glycoprotein Metabolic Process Extracellular Fibril Organization Blood Coagulation, Intrinsic Pathway Positive Regulation Of Urine Volume Response To Gravity Negative Regulation Of Tissue Remodeling Cellular Response To Vitamin D Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Renal Sodium Excretion Defense Response Blood Coagulation Regulation Of Excretion Hemostasis Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Phospholipid Catabolic Process Osteoblast Development Response To Epidermal Growth Factor Regulation Of Extracellular Matrix Disassembly	Cellular Response To Thyroid Hormone Stimulus Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Response To Thyroid Hormone Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Extracellular Matrix Organization Extracellular Structure Organization Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Positive Regulation Of Innate Immune Response Protein Catabolic Process Positive Regulation Of Immune Response Antigen Processing And Presentation Of Peptide Antigen Regulation Of Innate Immune Response Proteolysis Adaptive Immune Response Antigen Processing And Presentation Innate Immune Response Cellular Macromolecule Catabolic Process Regulation Of Immune Response Positive Regulation Of Immune System Process Catabolic Process Immune System Process Immune Response-regulating Signaling Pathway Basement Membrane Disassembly Macrophage Apoptotic Process Adult Locomotory Behavior Immune Response Regulation Of Immune System Process Defense Response Cellular Response To Hormone Stimulus Adult Behavior Myeloid Cell Apoptotic Process Positive Regulation Of Apoptotic Cell Clearance Inflammatory Cell Apoptotic Process Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Locomotory Behavior Regulation Of Apoptotic Cell Clearance Negative Regulation Of Endopeptidase Activity Response To Hormone Negative Regulation Of Peptidase Activity
Tagcloud ?		amounts bacteriuria capability capacitance capacitive consuming demand dissolved distinguishing exponential feasible fem finite gave giving ionic liquids measurable portable proposes sensor simulations solutions tangible top touch urine utis volumes	airflow analysing antiprotease bronchial brushings categorical causal causality cd22 copd curation cystatin dataset datasets eqtl fev fvc genomics integrative manual modelling oxidant relations silico snps trait triplets upregulating xenobiotic
Tagcloud (Difference) ?		amounts bacteriuria capability capacitance capacitive consuming demand dissolved distinguishing exponential feasible fem finite gave giving ionic liquids measurable portable proposes sensor simulations solutions tangible top touch urine utis volumes	airflow analysing antiprotease bronchial brushings categorical causal causality cd22 copd curation cystatin dataset datasets eqtl fev fvc genomics integrative manual modelling oxidant relations silico snps trait triplets upregulating xenobiotic
Tagcloud (Intersection) ?